Doxycycline

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Identification

Summary

Doxycycline is a tetracycline antibiotic used to treat a wide variety of bacterial infections.

Brand Names

Acticlate, Adoxa, Apprilon, Atridox, Doryx, Doxy, Doxycin, Lymepak, Mondoxyne, Monodox, Morgidox, Okebo, Oracea, Periostat, Targadox, Vibramycin

Generic Name

Doxycycline

DrugBank Accession Number

DB00254

Background

Doxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline.¹³ It is a second-generation tetracycline that was first discovered in 1967.⁶ Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines.⁵ Doxycycline is used to treat a wide variety of gram-positive and gram-negative bacterial infections. It is also used to treat acne and malaria.⁸

Type

Small Molecule

Groups

Approved, Investigational, Vet approved

Structure

Similar Structures

Weight: Average: 444.4346
Monoisotopic: 444.153265754
Chemical Formula: C₂₂H₂₄N₂O₈

Synonyms

5-hydroxy-α-6-deoxytetracycline
6-alpha-deoxy-5-oxytetracycline
6alpha-deoxy-5-oxytetracycline
6α-deoxy-5-oxytetracycline
Anhydrous doxycycline
Doxiciclina
Doxycyclin
Doxycycline
Doxycycline (anhydrous)
Doxycycline anhydrous
Doxycyclinum

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Pharmacology

Indication

Doxycycline is indicated for the treatment of various infections by gram-positive and gram-negative bacteria, aerobes and anaerobes, as well other types of bacteria, including:

Early Lyme disease (as evidenced by erythema migraines) due to Borrelia burgdorferi in adults and pediatric patients 8 years of age and older weighing 45 kg and above ¹²
Rickettsial infections,¹¹ such as Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox, and tick fevers ¹³
Sexually transmitted infections ¹¹
Respiratory tract infections ¹¹ caused by Mycoplasma pneumoniae and Haemophilus influenzae ¹³
Specific bacterial infections ¹¹ after indicative bacteriologic testing. These include infections caused by Escherichia coli, Enterobacter aerogenes, Shigella species, Acinetobacter species, and Klebsiella species ¹³
Ophthalmic infections,¹¹ such as inclusion conjunctivitis caused by Chlamydia trachomatis ¹³
Anthrax, including inhalational anthrax (post-exposure) ¹¹
Alternative treatment for selected infections when penicillin is contraindicated ¹¹
Adjunctive therapy in acute intestinal amebiasis and severe acne ^11,13
Lymphogranuloma venereum caused by Chlamydia trachomatis ¹³
Psittacosis (ornithosis) caused by Chlamydophila psittaci ¹³
Trachoma caused by Chlamydia trachomatis, although the infectious agent is not always eliminated, as judged by immunofluorescence ¹³
Uncomplicated urethral, endocervical, or rectal infections in adults caused by Chlamydia trachomatis ¹³
Nongonococcal urethritis caused by Ureaplasma urealyticum ¹³
Relapsing fever due to Borrelia recurrentis ¹³
Prophylaxis of malaria due to Plasmodium falciparum in short-term travelers (<4 months) to areas with chloroquine and/or pyrimethamine-sulfadoxine resistant strains ^11,13

It is also used to treat infections caused by the following gram-negative microorganisms:

Chancroid caused by Haemophilus ducreyi ¹³
Plague due to Yersinia pestis ¹³
Tularemia due to Francisella tularensis ¹³
Cholera caused by Vibrio cholerae ¹³
Campylobacter fetus infections caused by Campylobacter fetus ¹³
Brucellosis due to Brucella species (in conjunction with streptomycin) ¹³
Bartonellosis due to Bartonella bacilliformis ¹³
Granuloma inguinale caused by Klebsiella granulomatis ¹³

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Associated Conditions

Indication Type	Indication	Combined Product Details	Approval Level	Patient Characteristics	Dose Form
Treatment of	Acinetobacter infections		••••••••••••
Treatment of	Anthrax		••••••••••••
Treatment of	Bacterial infection caused by enterobacter aerogenes		••••••••••••
Treatment of	Bartonellosis		••••••••••••
Used in combination to treat	Brucellosis	Regimen in combination with: Streptomycin (DB01082)	••••••••••••
Treatment of	Campylobacter infection		••••••••••••
Treatment of	Chancroid		••••••••••••
Treatment of	Chlamydia trachomatis infection		••••••••••••
Treatment of	Early lyme disease		••••••••••••	•••• •••••• •• •• ••••• •• ••	••••••
Treatment of	Granuloma inguinale		••••••••••••
Treatment of	Infection due to escherichia coli		••••••••••••
Treatment of	Klebsiella infections		••••••••••••
Treatment of	Lymphogranuloma venereum		••••••••••••
Prophylaxis of	Malaria caused by plasmodium falciparum		••••••••••••
Treatment of	Nongonococcal urethritis		••••••••••••
Treatment of	Plague caused by yersinia pestis		••••••••••••
Treatment of	Psittacosis		••••••••••••
Treatment of	Rectal infection caused by chlamydia trachomatis		••••••••••••
Treatment of	Relapsing fever caused by borrelia recurrentis		••••••••••••
Treatment of	Respiratory tract infection bacterial		••••••••••••
Treatment of	Respiratory tract infection bacterial		••••••••••••
Treatment of	Rickettsial infectious disorders		••••••••••••
Adjunct therapy in treatment of	Severe acne		••••••••••••
Treatment of	Sexually transmitted infections (stis)		••••••••••••
Treatment of	Shigella infection		••••••••••••
Treatment of	Trachoma inclusion conjunctivitis		••••••••••••
Treatment of	Tularemia		••••••••••••
Treatment of	Vibrio cholerae infection		••••••••••••
Adjunct therapy in treatment of	Acute intestinal amebiasis		••••••••••••
Treatment of	Inhaled anthrax caused by bacillus anthracis		••••••••••••
Treatment of	Susceptible bacterial infections		••••••••••••
Treatment of	Uncomplicated endocervical infection		••••••••••••
Treatment of	Uncomplicated urethral infection		••••••••••••

Contraindications & Blackbox Warnings

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Pharmacodynamics

Doxycycline and other tetracyclines are mainly bacteriostatic and are thought to exert antimicrobial effects by the inhibition of protein synthesis. They suppress the growth of bacteria or keep them in the stationary phase of growth.³ Tetracyclines have antimicrobial spectrum of activity against a variety of gram-positive and gram-negative microorganisms.¹¹ Cross-resistance of these microorganisms to tetracyclines is a common occurrence.¹¹

As it is a highly lipophilic drug, doxycycline crosses multiple membranes of target molecules.⁸ Doxycycline shows favorable intra-cellular penetration, with bacteriostatic activity against a wide range of bacteria.⁹ Doxycycline also exhibits antiparasitic properties ^1,2,3 and anti-inflammatory actions.^4,8 Its anti-inflammatory effects were investigated in various inflammatory skin conditions, such as bullous dermatoses ⁸ and rosacea.^4,8

Mechanism of action

Protein synthesis is essential for survival and functioning of cells, including bacteria.⁷ Doxycycline inhibits bacterial protein synthesis by allosterically binding to the 30S prokaryotic ribosomal subunit.^8,11 The drug blocks the association charged aminoacyl-tRNA (aa-tRNA) with the ribosomal A site, which is the acceptor site on the mRNA-ribosome complex. Doxycycline ultimately impedes the elongation phase of protein synthesis and halts the production of essential proteins for bacterial survival and functioning.^7,8

Doxycycline mediates anti-inflammatory actions by preventing calcium-dependent microtubular assembly and lymphocytic proliferation, thereby inhibiting leukocyte movement during inflammation.⁸ It also inhibits nitric oxide synthase, which is an enzyme that produces nitric oxide, an inflammatory signaling molecule.⁸

Target	Actions	Organism
A30S ribosomal protein	inhibitor

Absorption

Doxycycline is virtually completely absorbed after oral administration ¹¹ with a bioavailability of ranging from 73-95%.¹⁰ Following an oral dose of 500 mg, the C_max of 15.3 mg/L was reached in four hours.¹⁰

Following a 200 mg dose, normal adult volunteers averaged peak serum levels of 2.6 mcg/mL of doxycycline at 2 hours, decreasing to 1.45 mcg/mL at 24 hours.¹³ While a high-fat meal lowers C_max and the rate of absorption, the effect is not clinically significant.¹¹

Volume of distribution

There is limited information available.

Protein binding

While there is limited information available, tetracyclines bound to plasma proteins in varying degree.¹³

Metabolism

There is limited information available.

Route of elimination

Tetracyclines, including doxycycline, are concentrated in bile by the liver and excreted in the urine and feces at high concentrations and in a biologically active form.¹¹ Excretion of doxycycline by the kidney is about 40%/72 hours in individuals with a creatinine clearance of about 75 mL/min. This percentage may fall as low as 1-5%/72 hours in individuals with a creatinine clearance below 10 mL/min.¹¹

Half-life

There is limited information available.

Clearance

Population pharmacokinetic analysis of sparse concentration-time data of doxycycline following standard of care intravenous and oral dosing in 44 pediatric patients two to 18 years of age showed allometrically -scaled clearance (CL) ranging from 3.27 to 3.58 L/h/70 kg.¹³

Adverse Effects

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Toxicity

Oral LD₅₀ is 2000 mg/kg in rats, 1870 mg/kg in mice, and 500 mg/kg in dog.¹⁴

In case of overdosage, doxycycline should be discontinued and symptomatic and supportive treatment should be initiated. Dialysis does not alter serum half-life and thus would not be of benefit in treating cases of overdosage.¹¹

Pathways

Pathway	Category
Doxycycline Action Pathway	Drug action

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Drug	Interaction
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Abacavir	Doxycycline may decrease the excretion rate of Abacavir which could result in a higher serum level.
Abciximab	The risk or severity of bleeding can be increased when Doxycycline is combined with Abciximab.
Aceclofenac	Aceclofenac may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Acemetacin	Acemetacin may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Acenocoumarol	The risk or severity of bleeding can be increased when Doxycycline is combined with Acenocoumarol.
Acetaminophen	Doxycycline may decrease the excretion rate of Acetaminophen which could result in a higher serum level.
Acetazolamide	Acetazolamide may increase the excretion rate of Doxycycline which could result in a lower serum level and potentially a reduction in efficacy.
Acetylsalicylic acid	Acetylsalicylic acid may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Acitretin	The risk or severity of pseudotumor cerebri can be increased when Acitretin is combined with Doxycycline.
Aclidinium	Doxycycline may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine	Doxycycline may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Acyclovir	Acyclovir may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Adefovir dipivoxil	Adefovir dipivoxil may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Albuterol	Doxycycline may decrease the excretion rate of Salbutamol which could result in a higher serum level.
Albutrepenonacog alfa	Doxycycline may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Alclofenac	Alclofenac may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Aldesleukin	Aldesleukin may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Alitretinoin	The risk or severity of pseudotumor cerebri can be increased when Alitretinoin is combined with Doxycycline.
Allopurinol	Doxycycline may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Almasilate	Almasilate can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Almotriptan	Doxycycline may decrease the excretion rate of Almotriptan which could result in a higher serum level.
Alogliptin	Doxycycline may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Alprazolam	Doxycycline may decrease the excretion rate of Alprazolam which could result in a higher serum level.
Alteplase	The risk or severity of bleeding can be increased when Doxycycline is combined with Alteplase.
Aluminium	Aluminium can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminium phosphate	Aluminium phosphate can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aluminum hydroxide	Aluminum hydroxide can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Amantadine	Doxycycline may decrease the excretion rate of Amantadine which could result in a higher serum level.
Ambroxol	The risk or severity of methemoglobinemia can be increased when Doxycycline is combined with Ambroxol.
Amikacin	Doxycycline may decrease the excretion rate of Amikacin which could result in a higher serum level.
Amiloride	Amiloride may increase the excretion rate of Doxycycline which could result in a lower serum level and potentially a reduction in efficacy.
Aminophenazone	Aminophenazone may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Amitriptyline	Doxycycline may decrease the excretion rate of Amitriptyline which could result in a higher serum level.
Ammonium chloride	Doxycycline may decrease the excretion rate of Ammonium chloride which could result in a higher serum level.
Amobarbital	The serum concentration of Doxycycline can be decreased when it is combined with Amobarbital.
Amoxicillin	The therapeutic efficacy of Amoxicillin can be decreased when used in combination with Doxycycline.
Amphetamine	Amphetamine may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Amphotericin B	Amphotericin B may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Ampicillin	The therapeutic efficacy of Ampicillin can be decreased when used in combination with Doxycycline.
Amrinone	Doxycycline may decrease the excretion rate of Amrinone which could result in a higher serum level.
Ancestim	Doxycycline may decrease the excretion rate of Ancestim which could result in a higher serum level.
Ancrod	The risk or severity of bleeding can be increased when Doxycycline is combined with Ancrod.
Anistreplase	The risk or severity of bleeding can be increased when Doxycycline is combined with Anistreplase.
Antihemophilic factor (recombinant), PEGylated	Doxycycline may decrease the excretion rate of Antihemophilic factor (recombinant), PEGylated which could result in a higher serum level.
Antipyrine	Antipyrine may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Antithrombin Alfa	The risk or severity of bleeding can be increased when Doxycycline is combined with Antithrombin Alfa.
Antithrombin III human	The risk or severity of bleeding can be increased when Doxycycline is combined with Antithrombin III human.
Antrafenine	Antrafenine may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Apalutamide	Doxycycline may decrease the excretion rate of Apalutamide which could result in a higher serum level.
Apixaban	The risk or severity of bleeding can be increased when Doxycycline is combined with Apixaban.
Apremilast	Doxycycline may decrease the excretion rate of Apremilast which could result in a higher serum level.
Ardeparin	The risk or severity of bleeding can be increased when Doxycycline is combined with Ardeparin.
Arformoterol	Doxycycline may decrease the excretion rate of Arformoterol which could result in a higher serum level.
Argatroban	The risk or severity of bleeding can be increased when Doxycycline is combined with Argatroban.
Arsenic trioxide	Doxycycline may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level.
Articaine	The risk or severity of methemoglobinemia can be increased when Doxycycline is combined with Articaine.
Ascorbic acid	The therapeutic efficacy of Doxycycline can be decreased when used in combination with Ascorbic acid.
Ascorbyl phosphate	The therapeutic efficacy of Doxycycline can be decreased when used in combination with Ascorbyl phosphate.
Atazanavir	Atazanavir may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Atomoxetine	Doxycycline may decrease the excretion rate of Atomoxetine which could result in a higher serum level.
Atracurium	The therapeutic efficacy of Atracurium can be increased when used in combination with Doxycycline.
Atracurium besylate	The therapeutic efficacy of Atracurium besylate can be increased when used in combination with Doxycycline.
Auranofin	Doxycycline may decrease the excretion rate of Auranofin which could result in a higher serum level.
Aurothioglucose	Doxycycline may decrease the excretion rate of Aurothioglucose which could result in a higher serum level.
Azacitidine	Doxycycline may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Azathioprine	Doxycycline may decrease the excretion rate of Azathioprine which could result in a higher serum level.
Azelaic acid	Doxycycline may decrease the excretion rate of Azelaic acid which could result in a higher serum level.
Azlocillin	The therapeutic efficacy of Azlocillin can be decreased when used in combination with Doxycycline.
Aztreonam	Doxycycline may decrease the excretion rate of Aztreonam which could result in a higher serum level.
Bacampicillin	The therapeutic efficacy of Bacampicillin can be decreased when used in combination with Doxycycline.
Bacitracin	Bacitracin may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Baclofen	Baclofen may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Balsalazide	Balsalazide may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Baricitinib	Doxycycline may decrease the excretion rate of Baricitinib which could result in a higher serum level.
BCG vaccine	The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Doxycycline.
Bemiparin	The risk or severity of bleeding can be increased when Doxycycline is combined with Bemiparin.
Bendroflumethiazide	Bendroflumethiazide may increase the excretion rate of Doxycycline which could result in a lower serum level and potentially a reduction in efficacy.
Benorilate	Benorilate may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Benoxaprofen	Benoxaprofen may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Benserazide	Doxycycline may decrease the excretion rate of Benserazide which could result in a higher serum level.
Benzatropine	Benzatropine may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Benznidazole	Doxycycline may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Benzocaine	The risk or severity of methemoglobinemia can be increased when Doxycycline is combined with Benzocaine.
Benzthiazide	Benzthiazide may increase the excretion rate of Doxycycline which could result in a lower serum level and potentially a reduction in efficacy.
Benzydamine	Benzydamine may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Benzyl alcohol	The risk or severity of methemoglobinemia can be increased when Doxycycline is combined with Benzyl alcohol.
Benzylpenicillin	The therapeutic efficacy of Benzylpenicillin can be decreased when used in combination with Doxycycline.
Benzylpenicilloyl polylysine	The therapeutic efficacy of Benzylpenicilloyl polylysine can be decreased when used in combination with Doxycycline.
Bepotastine	Doxycycline may decrease the excretion rate of Bepotastine which could result in a higher serum level.
Betrixaban	The risk or severity of bleeding can be increased when Doxycycline is combined with Betrixaban.
Bexarotene	The risk or severity of pseudotumor cerebri can be increased when Bexarotene is combined with Doxycycline.
Bicisate	Doxycycline may decrease the excretion rate of Bicisate which could result in a higher serum level.
Bismuth subcitrate potassium	The serum concentration of Doxycycline can be decreased when it is combined with Bismuth subcitrate potassium.
Bismuth subgallate	Doxycycline may decrease the excretion rate of Bismuth subgallate which could result in a higher serum level.
Bismuth subnitrate	Bismuth subnitrate can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Bismuth subsalicylate	The serum concentration of Doxycycline can be decreased when it is combined with Bismuth subsalicylate.
Bisoprolol	Doxycycline may decrease the excretion rate of Bisoprolol which could result in a higher serum level.
Bisoxatin	Doxycycline may decrease the excretion rate of Bisoxatin which could result in a higher serum level.
Bivalirudin	The risk or severity of bleeding can be increased when Doxycycline is combined with Bivalirudin.
Bleomycin	Doxycycline may decrease the excretion rate of Bleomycin which could result in a higher serum level.
Botulinum toxin type A	The therapeutic efficacy of Botulinum toxin type A can be increased when used in combination with Doxycycline.
Botulinum toxin type B	The risk or severity of adverse effects can be increased when Doxycycline is combined with Botulinum toxin type B.
Brivaracetam	Doxycycline may decrease the excretion rate of Brivaracetam which could result in a higher serum level.
Bromazepam	Doxycycline may decrease the excretion rate of Bromazepam which could result in a higher serum level.
Bromotheophylline	Bromotheophylline may increase the excretion rate of Doxycycline which could result in a lower serum level and potentially a reduction in efficacy.
Budesonide	Doxycycline may decrease the excretion rate of Budesonide which could result in a higher serum level.
Bumadizone	Bumadizone may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Bumetanide	Bumetanide may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Bupivacaine	The risk or severity of methemoglobinemia can be increased when Doxycycline is combined with Bupivacaine.
Bupropion	Doxycycline may decrease the excretion rate of Bupropion which could result in a higher serum level.
Buspirone	Doxycycline may decrease the excretion rate of Buspirone which could result in a higher serum level.
Butabarbital	The serum concentration of Doxycycline can be decreased when it is combined with Butabarbital.
Butacaine	The risk or severity of methemoglobinemia can be increased when Doxycycline is combined with Butacaine.
Butalbital	The serum concentration of Doxycycline can be decreased when it is combined with Butalbital.
Butamben	The risk or severity of methemoglobinemia can be increased when Doxycycline is combined with Butamben.
Calcium acetate	The serum concentration of Doxycycline can be decreased when it is combined with Calcium acetate.
Calcium ascorbate	The therapeutic efficacy of Doxycycline can be decreased when used in combination with Calcium ascorbate.
Calcium carbonate	Calcium carbonate can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium chloride	The serum concentration of Doxycycline can be decreased when it is combined with Calcium chloride.
Calcium citrate	The serum concentration of Doxycycline can be decreased when it is combined with Calcium citrate.
Calcium glubionate anhydrous	The serum concentration of Doxycycline can be decreased when it is combined with Calcium glubionate anhydrous.
Calcium glucoheptonate	The serum concentration of Doxycycline can be decreased when it is combined with Calcium glucoheptonate.
Calcium gluconate	The serum concentration of Doxycycline can be decreased when it is combined with Calcium gluconate.
Calcium lactate	The serum concentration of Doxycycline can be decreased when it is combined with Calcium lactate.
Calcium levulinate	The serum concentration of Doxycycline can be decreased when it is combined with Calcium levulinate.
Calcium Phosphate	The serum concentration of Doxycycline can be decreased when it is combined with Calcium Phosphate.
Calcium polycarbophil	The serum concentration of Doxycycline can be decreased when it is combined with Calcium polycarbophil.
Canagliflozin	Doxycycline may decrease the excretion rate of Canagliflozin which could result in a higher serum level.
Cangrelor	The risk or severity of bleeding can be increased when Doxycycline is combined with Cangrelor.
Canrenoic acid	Canrenoic acid may increase the excretion rate of Doxycycline which could result in a lower serum level and potentially a reduction in efficacy.
Capecitabine	Doxycycline may decrease the excretion rate of Capecitabine which could result in a higher serum level.
Capreomycin	Doxycycline may decrease the excretion rate of Capreomycin which could result in a higher serum level.
Capsaicin	The risk or severity of methemoglobinemia can be increased when Doxycycline is combined with Capsaicin.
Carbamazepine	Doxycycline may decrease the excretion rate of Carbamazepine which could result in a higher serum level.
Carbenicillin	The therapeutic efficacy of Carbenicillin can be decreased when used in combination with Doxycycline.
Carbidopa	Carbidopa may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Carbocromen	The therapeutic efficacy of Carbocromen can be increased when used in combination with Doxycycline.
Carboplatin	Carboplatin may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Carindacillin	The therapeutic efficacy of Carindacillin can be decreased when used in combination with Doxycycline.
Carmustine	Doxycycline may decrease the excretion rate of Carmustine which could result in a higher serum level.
Carprofen	Carprofen may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Cefaclor	Cefaclor may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Cefadroxil	Cefadroxil may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Cefalotin	Cefalotin may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Cefamandole	Cefamandole may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Cefapirin	Cefapirin may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Cefazolin	Cefazolin may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Cefdinir	Doxycycline may decrease the excretion rate of Cefdinir which could result in a higher serum level.
Cefditoren	Cefditoren may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Cefepime	Cefepime may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Cefmenoxime	Cefmenoxime may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Cefmetazole	Cefmetazole may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Cefonicid	Cefonicid may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Cefoperazone	Cefoperazone may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Ceforanide	Ceforanide may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Cefotaxime	Cefotaxime may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Cefotetan	Cefotetan may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Cefotiam	Cefotiam may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Cefoxitin	Cefoxitin may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Cefpiramide	Cefpiramide may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Cefpirome	Cefpirome may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Cefpodoxime	Cefpodoxime may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Cefprozil	Cefprozil may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Cefradine	Cefradine may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Ceftaroline fosamil	Ceftaroline fosamil may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Ceftazidime	Ceftazidime may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Ceftibuten	Ceftibuten may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Ceftizoxime	Ceftizoxime may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Ceftobiprole	Ceftobiprole may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Ceftolozane	Doxycycline may decrease the excretion rate of Ceftolozane which could result in a higher serum level.
Ceftriaxone	Ceftriaxone may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Cefuroxime	Cefuroxime may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Celecoxib	Celecoxib may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Cephalexin	Cephalexin may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Cephaloglycin	Cephaloglycin may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Certolizumab pegol	Doxycycline may decrease the excretion rate of Certolizumab pegol which could result in a higher serum level.
Cetirizine	Doxycycline may decrease the excretion rate of Cetirizine which could result in a higher serum level.
Cevimeline	Cevimeline may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Chloral hydrate	Doxycycline may decrease the excretion rate of Chloral hydrate which could result in a higher serum level.
Chloroprocaine	The risk or severity of methemoglobinemia can be increased when Doxycycline is combined with Chloroprocaine.
Chloroquine	The risk or severity of neuromuscular blockade can be increased when Doxycycline is combined with Chloroquine.
Chlorothiazide	Chlorothiazide may increase the excretion rate of Doxycycline which could result in a lower serum level and potentially a reduction in efficacy.
Chlorpromazine	Doxycycline may decrease the excretion rate of Chlorpromazine which could result in a higher serum level.
Chlorpropamide	Doxycycline may decrease the excretion rate of Chlorpropamide which could result in a higher serum level.
Chlorthalidone	Chlorthalidone may increase the excretion rate of Doxycycline which could result in a lower serum level and potentially a reduction in efficacy.
Chlorzoxazone	Doxycycline may decrease the excretion rate of Chlorzoxazone which could result in a higher serum level.
Cholestyramine	Cholestyramine can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Choline C 11	Doxycycline may decrease the excretion rate of Choline C 11 which could result in a higher serum level.
Choline magnesium trisalicylate	Choline magnesium trisalicylate may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Choline salicylate	Doxycycline may decrease the excretion rate of Choline salicylate which could result in a higher serum level.
Chondroitin sulfate	Doxycycline may decrease the excretion rate of Chondroitin sulfate which could result in a higher serum level.
Chromic chloride	Doxycycline may decrease the excretion rate of Chromic chloride which could result in a higher serum level.
Chromic nitrate	Doxycycline may decrease the excretion rate of Chromic nitrate which could result in a higher serum level.
Chromium	Doxycycline may decrease the excretion rate of Chromium which could result in a higher serum level.
Chromium gluconate	Doxycycline may decrease the excretion rate of Chromium gluconate which could result in a higher serum level.
Chromium nicotinate	Doxycycline may decrease the excretion rate of Chromium nicotinate which could result in a higher serum level.
Chromous sulfate	Doxycycline may decrease the excretion rate of Chromous sulfate which could result in a higher serum level.
Cidofovir	Cidofovir may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Cilostazol	Doxycycline may decrease the excretion rate of Cilostazol which could result in a higher serum level.
Cimetidine	Doxycycline may decrease the excretion rate of Cimetidine which could result in a higher serum level.
Cinchocaine	The risk or severity of methemoglobinemia can be increased when Doxycycline is combined with Cinchocaine.
Ciprofloxacin	Doxycycline may decrease the excretion rate of Ciprofloxacin which could result in a higher serum level.
Cisatracurium	Doxycycline may increase the neuromuscular blocking activities of Cisatracurium.
Cisplatin	Doxycycline may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Citric acid	The therapeutic efficacy of Doxycycline can be decreased when used in combination with Citric acid.
Clevidipine	Doxycycline may decrease the excretion rate of Clevidipine which could result in a higher serum level.
Clindamycin	The risk or severity of neuromuscular blockade can be increased when Doxycycline is combined with Clindamycin.
Clobazam	Doxycycline may decrease the excretion rate of Clobazam which could result in a higher serum level.
Clofarabine	Doxycycline may decrease the excretion rate of Clofarabine which could result in a higher serum level.
Clomipramine	Doxycycline may decrease the excretion rate of Clomipramine which could result in a higher serum level.
Clonazepam	Doxycycline may decrease the excretion rate of Clonazepam which could result in a higher serum level.
Clorazepic acid	Doxycycline may decrease the excretion rate of Clorazepic acid which could result in a higher serum level.
Clove oil	Doxycycline may decrease the excretion rate of Clove oil which could result in a higher serum level.
Cloxacillin	The therapeutic efficacy of Cloxacillin can be decreased when used in combination with Doxycycline.
Clozapine	Doxycycline may decrease the excretion rate of Clozapine which could result in a higher serum level.
Cocaine	The risk or severity of methemoglobinemia can be increased when Doxycycline is combined with Cocaine.
Colchicine	Doxycycline may decrease the excretion rate of Colchicine which could result in a higher serum level.
Colesevelam	Colesevelam can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Colestipol	Colestipol can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Colistimethate	The risk or severity of neuromuscular blockade can be increased when Doxycycline is combined with Colistimethate.
Colistin	Doxycycline may decrease the excretion rate of Colistin which could result in a higher serum level.
Collagenase clostridium histolyticum	The therapeutic efficacy of Collagenase clostridium histolyticum can be decreased when used in combination with Doxycycline.
Conivaptan	Conivaptan may increase the excretion rate of Doxycycline which could result in a lower serum level and potentially a reduction in efficacy.
Conjugated estrogens	Doxycycline may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Corifollitropin alfa	Doxycycline may decrease the excretion rate of Corifollitropin alfa which could result in a higher serum level.
Cyanocobalamin	Cyanocobalamin may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Cyclacillin	The therapeutic efficacy of Cyclacillin can be decreased when used in combination with Doxycycline.
Cyclopenthiazide	Cyclopenthiazide may increase the excretion rate of Doxycycline which could result in a lower serum level and potentially a reduction in efficacy.
Cyclosporine	The risk or severity of neuromuscular blockade can be increased when Cyclosporine is combined with Doxycycline.
Cyclothiazide	Cyclothiazide may increase the excretion rate of Doxycycline which could result in a lower serum level and potentially a reduction in efficacy.
Cyproterone acetate	The serum concentration of Cyproterone acetate can be decreased when it is combined with Doxycycline.
Dabigatran	The risk or severity of bleeding can be increased when Doxycycline is combined with Dabigatran.
Dabigatran etexilate	The risk or severity of bleeding can be increased when Doxycycline is combined with Dabigatran etexilate.
Dacarbazine	Doxycycline may decrease the excretion rate of Dacarbazine which could result in a higher serum level.
Dalfampridine	Doxycycline may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
Dalteparin	The risk or severity of bleeding can be increased when Doxycycline is combined with Dalteparin.
Danaparoid	The risk or severity of bleeding can be increased when Doxycycline is combined with Danaparoid.
Dantrolene	The risk or severity of neuromuscular blockade can be increased when Doxycycline is combined with Dantrolene.
Daptomycin	Daptomycin may decrease the excretion rate of Doxycycline which could result in a higher serum level.
DaxibotulinumtoxinA	The therapeutic efficacy of DaxibotulinumtoxinA can be increased when used in combination with Doxycycline.
Decamethonium	The therapeutic efficacy of Decamethonium can be increased when used in combination with Doxycycline.
Deferiprone	Doxycycline may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Defibrotide	The risk or severity of bleeding can be increased when Doxycycline is combined with Defibrotide.
Delafloxacin	Doxycycline may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Demeclocycline	The risk or severity of neuromuscular blockade can be increased when Doxycycline is combined with Demeclocycline.
Desipramine	Doxycycline may decrease the excretion rate of Desipramine which could result in a higher serum level.
Desirudin	The risk or severity of bleeding can be increased when Doxycycline is combined with Desirudin.
Desmopressin	Desmopressin may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Desogestrel	The serum concentration of Desogestrel can be decreased when it is combined with Doxycycline.
Desvenlafaxine	Doxycycline may decrease the excretion rate of Desvenlafaxine which could result in a higher serum level.
Deutetrabenazine	Doxycycline may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Dexibuprofen	Dexibuprofen may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Dexketoprofen	Dexketoprofen may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Dexlansoprazole	Dexlansoprazole can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dexmedetomidine	Doxycycline may decrease the excretion rate of Dexmedetomidine which could result in a higher serum level.
Dexpanthenol	Doxycycline may decrease the excretion rate of Dexpanthenol which could result in a higher serum level.
Dexrazoxane	Doxycycline may decrease the excretion rate of Dexrazoxane which could result in a higher serum level.
Dextran	The risk or severity of bleeding can be increased when Doxycycline is combined with Dextran.
Diatrizoate	Doxycycline may decrease the excretion rate of Diatrizoate which could result in a higher serum level.
Diazepam	Doxycycline may decrease the excretion rate of Diazepam which could result in a higher serum level.
Dichlorobenzyl alcohol	Doxycycline may decrease the excretion rate of Dichlorobenzyl alcohol which could result in a higher serum level.
Diclofenac	Diclofenac may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Diclofenamide	Diclofenamide may increase the excretion rate of Doxycycline which could result in a lower serum level and potentially a reduction in efficacy.
Dicloxacillin	The therapeutic efficacy of Dicloxacillin can be decreased when used in combination with Doxycycline.
Dicoumarol	The risk or severity of bleeding can be increased when Doxycycline is combined with Dicoumarol.
Dicyclomine	Doxycycline may decrease the excretion rate of Dicyclomine which could result in a higher serum level.
Didanosine	Didanosine can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dienogest	The serum concentration of Dienogest can be decreased when it is combined with Doxycycline.
Diethylstilbestrol	The serum concentration of Diethylstilbestrol can be decreased when it is combined with Doxycycline.
Diflunisal	Diflunisal may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Difluocortolone	Doxycycline may decrease the excretion rate of Difluocortolone which could result in a higher serum level.
Digoxin	Doxycycline may decrease the excretion rate of Digoxin which could result in a higher serum level.
Dihydrostreptomycin	The risk or severity of neuromuscular blockade can be increased when Doxycycline is combined with Dihydrostreptomycin.
Dimercaprol	Doxycycline may decrease the excretion rate of Dimercaprol which could result in a higher serum level.
Dimethyl sulfoxide	Doxycycline may decrease the excretion rate of Dimethyl sulfoxide which could result in a higher serum level.
Diphenhydramine	The risk or severity of methemoglobinemia can be increased when Doxycycline is combined with Diphenhydramine.
Dipyridamole	The risk or severity of bleeding can be increased when Doxycycline is combined with Dipyridamole.
Disopyramide	Doxycycline may decrease the excretion rate of Disopyramide which could result in a higher serum level.
DL-Methylephedrine	Doxycycline may decrease the excretion rate of DL-Methylephedrine which could result in a higher serum level.
Dobutamine	Doxycycline may decrease the excretion rate of Dobutamine which could result in a higher serum level.
Dopamine	Doxycycline may decrease the excretion rate of Dopamine which could result in a higher serum level.
Doripenem	Doxycycline may decrease the excretion rate of Doripenem which could result in a higher serum level.
Doxacurium	The therapeutic efficacy of Doxacurium can be increased when used in combination with Doxycycline.
Doxepin	Doxycycline may decrease the excretion rate of Doxepin which could result in a higher serum level.
Drospirenone	The serum concentration of Drospirenone can be decreased when it is combined with Doxycycline.
Drotrecogin alfa	The risk or severity of bleeding can be increased when Doxycycline is combined with Drotrecogin alfa.
Droxidopa	Doxycycline may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Duloxetine	Doxycycline may decrease the excretion rate of Duloxetine which could result in a higher serum level.
Dyclonine	The risk or severity of methemoglobinemia can be increased when Doxycycline is combined with Dyclonine.
Dydrogesterone	The serum concentration of Dydrogesterone can be decreased when it is combined with Doxycycline.
Dyphylline	Doxycycline may decrease the excretion rate of Dyphylline which could result in a higher serum level.
Edetic acid	The risk or severity of bleeding can be increased when Doxycycline is combined with Edetic acid.
Edoxaban	The risk or severity of bleeding can be increased when Doxycycline is combined with Edoxaban.
Edrophonium	Doxycycline may decrease the excretion rate of Edrophonium which could result in a higher serum level.
Enalaprilat	Doxycycline may decrease the excretion rate of Enalaprilat which could result in a higher serum level.
Enoxaparin	The risk or severity of bleeding can be increased when Doxycycline is combined with Enoxaparin.
Enzalutamide	Doxycycline may decrease the excretion rate of Enzalutamide which could result in a higher serum level.
Eplerenone	Eplerenone may increase the excretion rate of Doxycycline which could result in a lower serum level and potentially a reduction in efficacy.
Epoprostenol	The risk or severity of bleeding can be increased when Doxycycline is combined with Epoprostenol.
Ertapenem	Doxycycline may decrease the excretion rate of Ertapenem which could result in a higher serum level.
Esculin	The therapeutic efficacy of Esculin can be increased when used in combination with Doxycycline.
Esomeprazole	Esomeprazole can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Estazolam	Doxycycline may decrease the excretion rate of Estazolam which could result in a higher serum level.
Estetrol	The therapeutic efficacy of Estetrol can be decreased when used in combination with Doxycycline.
Estradiol	Doxycycline may decrease the excretion rate of Estradiol which could result in a higher serum level.
Estradiol acetate	Doxycycline may decrease the excretion rate of Estradiol acetate which could result in a higher serum level.
Estradiol benzoate	The serum concentration of Estradiol benzoate can be decreased when it is combined with Doxycycline.
Estradiol cypionate	Doxycycline may decrease the excretion rate of Estradiol cypionate which could result in a higher serum level.
Estradiol dienanthate	Doxycycline may decrease the excretion rate of Estradiol dienanthate which could result in a higher serum level.
Estradiol valerate	Doxycycline may decrease the excretion rate of Estradiol valerate which could result in a higher serum level.
Estrone sulfate	Doxycycline may decrease the excretion rate of Estrone sulfate which could result in a higher serum level.
Eszopiclone	Doxycycline may decrease the excretion rate of Eszopiclone which could result in a higher serum level.
Etacrynic acid	The risk or severity of neuromuscular blockade can be increased when Doxycycline is combined with Etacrynic acid.
Etafedrine	Doxycycline may decrease the excretion rate of Etafedrine which could result in a higher serum level.
Ethambutol	Doxycycline may decrease the excretion rate of Ethambutol which could result in a higher serum level.
Ethinylestradiol	The serum concentration of Ethinylestradiol can be decreased when it is combined with Doxycycline.
Ethyl chloride	The risk or severity of methemoglobinemia can be increased when Doxycycline is combined with Ethyl chloride.
Ethynodiol diacetate	The serum concentration of Ethynodiol diacetate can be decreased when it is combined with Doxycycline.
Etidocaine	The risk or severity of methemoglobinemia can be increased when Doxycycline is combined with Etidocaine.
Etodolac	Etodolac may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Etomidate	Doxycycline may decrease the excretion rate of Etomidate which could result in a higher serum level.
Etonogestrel	The serum concentration of Etonogestrel can be decreased when it is combined with Doxycycline.
Etoricoxib	Etoricoxib may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Eucalyptus oil	Doxycycline may decrease the excretion rate of Eucalyptus oil which could result in a higher serum level.
Ezogabine	Doxycycline may decrease the excretion rate of Ezogabine which could result in a higher serum level.
Fecal microbiota	The therapeutic efficacy of Fecal microbiota can be decreased when used in combination with Doxycycline.
Fenbufen	Fenbufen may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Fenofibrate	Doxycycline may decrease the excretion rate of Fenofibrate which could result in a higher serum level.
Fenofibric acid	Doxycycline may decrease the excretion rate of Fenofibric acid which could result in a higher serum level.
Fenoldopam	Doxycycline may decrease the excretion rate of Fenoldopam which could result in a higher serum level.
Fenoprofen	Fenoprofen may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Fentanyl	Doxycycline may decrease the excretion rate of Fentanyl which could result in a higher serum level.
Ferric ammonium citrate	Doxycycline can cause a decrease in the absorption of Ferric ammonium citrate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric cation	Doxycycline can cause a decrease in the absorption of Ferric cation resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric maltol	Doxycycline can cause a decrease in the absorption of Ferric maltol resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric sulfate	Doxycycline can cause a decrease in the absorption of Ferric sulfate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferrous bisglycinate	Doxycycline can cause a decrease in the absorption of Ferrous bisglycinate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferrous fumarate	Doxycycline can cause a decrease in the absorption of Ferrous fumarate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferrous gluconate	Doxycycline can cause a decrease in the absorption of Ferrous gluconate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferrous succinate	Doxycycline can cause a decrease in the absorption of Ferrous succinate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferrous sulfate anhydrous	Doxycycline can cause a decrease in the absorption of Ferrous sulfate anhydrous resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferumoxides	Doxycycline can cause a decrease in the absorption of Ferumoxides resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferumoxsil	Doxycycline can cause a decrease in the absorption of Ferumoxsil resulting in a reduced serum concentration and potentially a decrease in efficacy.
Fesoterodine	Doxycycline may decrease the excretion rate of Fesoterodine which could result in a higher serum level.
Finerenone	Finerenone may increase the excretion rate of Doxycycline which could result in a lower serum level and potentially a reduction in efficacy.
Flavoxate	Doxycycline may decrease the excretion rate of Flavoxate which could result in a higher serum level.
Floctafenine	Floctafenine may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Florbetaben F-18	Doxycycline may decrease the excretion rate of Florbetaben (18F) which could result in a higher serum level.
Florbetapir (18F)	Doxycycline may decrease the excretion rate of Florbetapir (18F) which could result in a higher serum level.
Floxuridine	Doxycycline may decrease the excretion rate of Floxuridine which could result in a higher serum level.
Flucloxacillin	The therapeutic efficacy of Flucloxacillin can be decreased when used in combination with Doxycycline.
Fluconazole	Fluconazole may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Flucytosine	Doxycycline may decrease the excretion rate of Flucytosine which could result in a higher serum level.
Fludeoxyglucose (18F)	Doxycycline may decrease the excretion rate of Fludeoxyglucose (18F) which could result in a higher serum level.
Fluindione	The risk or severity of bleeding can be increased when Doxycycline is combined with Fluindione.
Flumazenil	Doxycycline may decrease the excretion rate of Flumazenil which could result in a higher serum level.
Fluocinolone acetonide	Doxycycline may decrease the excretion rate of Fluocinolone acetonide which could result in a higher serum level.
Flurazepam	Doxycycline may decrease the excretion rate of Flurazepam which could result in a higher serum level.
Flurbiprofen	Flurbiprofen may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Flutamide	Doxycycline may decrease the excretion rate of Flutamide which could result in a higher serum level.
Fluvoxamine	Fluvoxamine may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Folic acid	Folic acid may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Fomepizole	Doxycycline may decrease the excretion rate of Fomepizole which could result in a higher serum level.
Fondaparinux	The risk or severity of bleeding can be increased when Doxycycline is combined with Fondaparinux.
Formestane	Doxycycline may decrease the excretion rate of Formestane which could result in a higher serum level.
Foscarnet	Foscarnet may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Fosfomycin	Doxycycline may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Fosinopril	Doxycycline may decrease the excretion rate of Fosinopril which could result in a higher serum level.
Fosphenytoin	The serum concentration of Doxycycline can be decreased when it is combined with Fosphenytoin.
Framycetin	The risk or severity of neuromuscular blockade can be increased when Doxycycline is combined with Framycetin.
Furosemide	Furosemide may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Gabapentin enacarbil	Doxycycline may decrease the excretion rate of Gabapentin enacarbil which could result in a higher serum level.
Gadobenic acid	Doxycycline may decrease the excretion rate of Gadobenic acid which could result in a higher serum level.
Gadodiamide	Gadodiamide may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Gadofosveset trisodium	Doxycycline may decrease the excretion rate of Gadofosveset trisodium which could result in a higher serum level.
Gadopentetic acid	Doxycycline may decrease the excretion rate of Gadopentetic acid which could result in a higher serum level.
Gadoteric acid	Doxycycline may decrease the excretion rate of Gadoteric acid which could result in a higher serum level.
Gadoteridol	Doxycycline may decrease the excretion rate of Gadoteridol which could result in a higher serum level.
Gallamine triethiodide	The therapeutic efficacy of Gallamine triethiodide can be increased when used in combination with Doxycycline.
Ganciclovir	Doxycycline may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Gemcitabine	Doxycycline may decrease the excretion rate of Gemcitabine which could result in a higher serum level.
Gemfibrozil	Doxycycline may decrease the excretion rate of Gemfibrozil which could result in a higher serum level.
Gentamicin	Doxycycline may decrease the excretion rate of Gentamicin which could result in a higher serum level.
Gestrinone	The serum concentration of Gestrinone can be decreased when it is combined with Doxycycline.
Gimeracil	Doxycycline may decrease the excretion rate of Gimeracil which could result in a higher serum level.
Givosiran	Givosiran may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Glipizide	Doxycycline may decrease the excretion rate of Glipizide which could result in a higher serum level.
Glycerol phenylbutyrate	Doxycycline may decrease the excretion rate of Glycerol phenylbutyrate which could result in a higher serum level.
Golodirsen	Doxycycline may decrease the excretion rate of Golodirsen which could result in a higher serum level.
Goserelin	Goserelin may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Guanethidine	Doxycycline may decrease the excretion rate of Guanethidine which could result in a higher serum level.
Guanfacine	Doxycycline may decrease the excretion rate of Guanfacine which could result in a higher serum level.
Haloperidol	Doxycycline may decrease the excretion rate of Haloperidol which could result in a higher serum level.
Heparin	The risk or severity of bleeding can be increased when Doxycycline is combined with Heparin.
Hetacillin	The therapeutic efficacy of Hetacillin can be decreased when used in combination with Doxycycline.
Hydralazine	Doxycycline may decrease the excretion rate of Hydralazine which could result in a higher serum level.
Hydrochlorothiazide	Hydrochlorothiazide may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Hydroflumethiazide	Hydroflumethiazide may increase the excretion rate of Doxycycline which could result in a lower serum level and potentially a reduction in efficacy.
Hydromorphone	Doxycycline may decrease the excretion rate of Hydromorphone which could result in a higher serum level.
Hydrotalcite	The absorption of Doxycycline can be decreased when combined with Hydrotalcite.
Hydroxocobalamin	Hydroxocobalamin may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Hydroxyethyl Starch	Doxycycline may decrease the excretion rate of Hydroxyethyl Starch which could result in a higher serum level.
Hydroxyprogesterone caproate	The serum concentration of Hydroxyprogesterone caproate can be decreased when it is combined with Doxycycline.
Ibuprofen	Ibuprofen may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Ibutilide	Doxycycline may decrease the excretion rate of Ibutilide which could result in a higher serum level.
Icatibant	Doxycycline may decrease the excretion rate of Icatibant which could result in a higher serum level.
Icosapent	Icosapent may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Idarucizumab	Doxycycline may decrease the excretion rate of Idarucizumab which could result in a higher serum level.
Idebenone	Doxycycline may decrease the excretion rate of Idebenone which could result in a higher serum level.
Ifosfamide	Doxycycline may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Imipramine	Doxycycline may decrease the excretion rate of Imipramine which could result in a higher serum level.
Indapamide	Doxycycline may decrease the excretion rate of Indapamide which could result in a higher serum level.
Indigotindisulfonic acid	Doxycycline may decrease the excretion rate of Indigotindisulfonic acid which could result in a higher serum level.
Indomethacin	Indomethacin may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Inosine pranobex	Doxycycline may decrease the excretion rate of Inosine pranobex which could result in a higher serum level.
Inositol	Doxycycline may decrease the excretion rate of Inositol which could result in a higher serum level.
Inotersen	Inotersen may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Iobenguane sulfate I-123	Doxycycline may decrease the excretion rate of Iobenguane sulfate I-123 which could result in a higher serum level.
Iodixanol	Doxycycline may decrease the excretion rate of Iodixanol which could result in a higher serum level.
Ioflupane I-123	Doxycycline may decrease the excretion rate of Ioflupane I-123 which could result in a higher serum level.
Iopromide	Doxycycline may decrease the excretion rate of Iopromide which could result in a higher serum level.
Iothalamic acid	Doxycycline may decrease the excretion rate of Iothalamic acid which could result in a higher serum level.
Ioversol	Doxycycline may decrease the excretion rate of Ioversol which could result in a higher serum level.
Ioxilan	Doxycycline may decrease the excretion rate of Ioxilan which could result in a higher serum level.
Ipecac	Doxycycline may decrease the excretion rate of Ipecac which could result in a higher serum level.
Ipilimumab	Doxycycline may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Iron	Doxycycline can cause a decrease in the absorption of Iron resulting in a reduced serum concentration and potentially a decrease in efficacy.
Iron Dextran	Doxycycline can cause a decrease in the absorption of Iron Dextran resulting in a reduced serum concentration and potentially a decrease in efficacy.
Iron sucrose	The serum concentration of Doxycycline can be decreased when it is combined with Iron sucrose.
Isoniazid	Doxycycline may decrease the excretion rate of Isoniazid which could result in a higher serum level.
Isosorbide	Isosorbide may increase the excretion rate of Doxycycline which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide mononitrate	Doxycycline may decrease the excretion rate of Isosorbide mononitrate which could result in a higher serum level.
Isosulfan blue	Doxycycline may decrease the excretion rate of Isosulfan blue which could result in a higher serum level.
Isotretinoin	The risk or severity of pseudotumor cerebri can be increased when Isotretinoin is combined with Doxycycline.
Isoxicam	Isoxicam may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Isradipine	Doxycycline may decrease the excretion rate of Isradipine which could result in a higher serum level.
Ixazomib	Doxycycline may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Kanamycin	Doxycycline may decrease the excretion rate of Kanamycin which could result in a higher serum level.
Ketamine	Doxycycline may decrease the excretion rate of Ketamine which could result in a higher serum level.
Ketazolam	Doxycycline may decrease the excretion rate of Ketazolam which could result in a higher serum level.
Ketoprofen	Ketoprofen may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Ketorolac	Ketorolac may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Labetalol	Doxycycline may decrease the excretion rate of Labetalol which could result in a higher serum level.
Lactulose	The therapeutic efficacy of Lactulose can be decreased when used in combination with Doxycycline.
Lamivudine	Doxycycline may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Lamotrigine	Doxycycline may decrease the excretion rate of Lamotrigine which could result in a higher serum level.
Lansoprazole	Lansoprazole can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lanthanum carbonate	The serum concentration of Doxycycline can be decreased when it is combined with Lanthanum carbonate.
Latamoxef	Latamoxef may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Ledipasvir	Doxycycline may decrease the excretion rate of Ledipasvir which could result in a higher serum level.
Lenalidomide	Doxycycline may decrease the excretion rate of Lenalidomide which could result in a higher serum level.
Lepirudin	The risk or severity of bleeding can be increased when Doxycycline is combined with Lepirudin.
Lesinurad	Doxycycline may decrease the excretion rate of Lesinurad which could result in a higher serum level.
LetibotulinumtoxinA	The therapeutic efficacy of Letibotulinumtoxina can be increased when used in combination with Doxycycline.
Leuprolide	Leuprolide may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Levobupivacaine	The risk or severity of methemoglobinemia can be increased when Doxycycline is combined with Levobupivacaine.
Levocarnitine	Doxycycline may decrease the excretion rate of Levocarnitine which could result in a higher serum level.
Levocetirizine	Doxycycline may decrease the excretion rate of Levocetirizine which could result in a higher serum level.
Levofloxacin	Doxycycline may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Levomilnacipran	Doxycycline may decrease the excretion rate of Levomilnacipran which could result in a higher serum level.
Levonorgestrel	The serum concentration of Levonorgestrel can be decreased when it is combined with Doxycycline.
Levosalbutamol	Doxycycline may decrease the excretion rate of Levosalbutamol which could result in a higher serum level.
Lidocaine	The risk or severity of methemoglobinemia can be increased when Doxycycline is combined with Lidocaine.
Lincomycin	The risk or severity of neuromuscular blockade can be increased when Doxycycline is combined with Lincomycin.
Liothyronine	Doxycycline may decrease the excretion rate of Liothyronine which could result in a higher serum level.
Lisinopril	Doxycycline may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Lithium carbonate	Doxycycline may decrease the excretion rate of Lithium carbonate which could result in a higher serum level.
Lithium citrate	Lithium citrate may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Lixisenatide	Doxycycline may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Lofexidine	Doxycycline may decrease the excretion rate of Lofexidine which could result in a higher serum level.
Lopinavir	Lopinavir may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Loracarbef	Loracarbef may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Lorazepam	Lorazepam may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Lorcaserin	Doxycycline may decrease the excretion rate of Lorcaserin which could result in a higher serum level.
Lornoxicam	Lornoxicam may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Lorpiprazole	Doxycycline may decrease the excretion rate of Lorpiprazole which could result in a higher serum level.
Loxoprofen	Loxoprofen may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Lubiprostone	Doxycycline may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Lumiracoxib	Lumiracoxib may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Lymecycline	The risk or severity of neuromuscular blockade can be increased when Doxycycline is combined with Lymecycline.
Lynestrenol	The serum concentration of Lynestrenol can be decreased when it is combined with Doxycycline.
Macitentan	Doxycycline may decrease the excretion rate of Macitentan which could result in a higher serum level.
Magaldrate	The absorption of Doxycycline can be decreased when combined with Magaldrate.
Magnesium	The absorption of Doxycycline can be decreased when combined with Magnesium.
Magnesium acetate	The risk or severity of neuromuscular blockade can be increased when Doxycycline is combined with Magnesium acetate.
Magnesium acetate tetrahydrate	The risk or severity of neuromuscular blockade can be increased when Doxycycline is combined with Magnesium acetate tetrahydrate.
Magnesium Aluminum Silicate	The risk or severity of neuromuscular blockade can be increased when Doxycycline is combined with Magnesium Aluminum Silicate.
Magnesium carbonate	The absorption of Doxycycline can be decreased when combined with Magnesium carbonate.
Magnesium cation	The risk or severity of neuromuscular blockade can be increased when Doxycycline is combined with Magnesium cation.
Magnesium chloride	The absorption of Doxycycline can be decreased when combined with Magnesium chloride.
Magnesium citrate	The absorption of Doxycycline can be decreased when combined with Magnesium citrate.
Magnesium gluconate	The absorption of Doxycycline can be decreased when combined with Magnesium gluconate.
Magnesium glycinate	The risk or severity of neuromuscular blockade can be increased when Doxycycline is combined with Magnesium glycinate.
Magnesium hydroxide	The absorption of Doxycycline can be decreased when combined with Magnesium hydroxide.
Magnesium oxide	The absorption of Doxycycline can be decreased when combined with Magnesium oxide.
Magnesium silicate	The absorption of Doxycycline can be decreased when combined with Magnesium silicate.
Magnesium sulfate	The absorption of Doxycycline can be decreased when combined with Magnesium sulfate.
Magnesium trisilicate	The absorption of Doxycycline can be decreased when combined with Magnesium trisilicate.
Mangafodipir	Doxycycline may decrease the excretion rate of Mangafodipir which could result in a higher serum level.
Mannitol	Mannitol may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Maprotiline	Doxycycline may decrease the excretion rate of Maprotiline which could result in a higher serum level.
Mecamylamine	Doxycycline may increase the neuromuscular blocking activities of Mecamylamine.
Meclofenamic acid	Meclofenamic acid may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Medrogestone	The serum concentration of Medrogestone can be decreased when it is combined with Doxycycline.
Medroxyprogesterone acetate	The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Doxycycline.
Mefenamic acid	Mefenamic acid may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Megestrol acetate	The serum concentration of Megestrol acetate can be decreased when it is combined with Doxycycline.
Meloxicam	The risk or severity of methemoglobinemia can be increased when Doxycycline is combined with Meloxicam.
Memantine	Doxycycline may decrease the excretion rate of Memantine which could result in a higher serum level.
Meperidine	Doxycycline may decrease the excretion rate of Meperidine which could result in a higher serum level.
Mepivacaine	The risk or severity of methemoglobinemia can be increased when Doxycycline is combined with Mepivacaine.
Meropenem	Doxycycline may decrease the excretion rate of Meropenem which could result in a higher serum level.
Mesalazine	Mesalazine may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Mestranol	The serum concentration of Mestranol can be decreased when it is combined with Doxycycline.
Metacycline	The risk or severity of neuromuscular blockade can be increased when Doxycycline is combined with Metacycline.
Metamfetamine	Doxycycline may decrease the excretion rate of Metamfetamine which could result in a higher serum level.
Metamizole	Metamizole may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Metaxalone	Doxycycline may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Metformin	Doxycycline may decrease the excretion rate of Metformin which could result in a higher serum level.
Methadone	Doxycycline may decrease the excretion rate of Methadone which could result in a higher serum level.
Methazolamide	Methazolamide may increase the excretion rate of Doxycycline which could result in a lower serum level and potentially a reduction in efficacy.
Methimazole	Doxycycline may decrease the excretion rate of Methimazole which could result in a higher serum level.
Methohexital	The serum concentration of Doxycycline can be decreased when it is combined with Methohexital.
Methotrexate	Doxycycline can cause a decrease in the absorption of Methotrexate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Methoxsalen	Doxycycline may decrease the excretion rate of Methoxsalen which could result in a higher serum level.
Methoxyflurane	The risk or severity of renal failure can be increased when Doxycycline is combined with Methoxyflurane.
Methyldopa	Doxycycline may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Methylene blue	Doxycycline may decrease the excretion rate of Methylene blue which could result in a higher serum level.
Methylnaltrexone	Doxycycline may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Methylphenobarbital	The serum concentration of Doxycycline can be decreased when it is combined with Methylphenobarbital.
Methyltestosterone	Doxycycline may decrease the excretion rate of Methyltestosterone which could result in a higher serum level.
Meticillin	The therapeutic efficacy of Meticillin can be decreased when used in combination with Doxycycline.
Meticrane	Meticrane may increase the excretion rate of Doxycycline which could result in a lower serum level and potentially a reduction in efficacy.
Metoclopramide	Doxycycline may decrease the excretion rate of Metoclopramide which could result in a higher serum level.
Metocurine	The therapeutic efficacy of Metocurine can be increased when used in combination with Doxycycline.
Metocurine iodide	The therapeutic efficacy of Metocurine iodide can be increased when used in combination with Doxycycline.
Metolazone	Doxycycline may decrease the excretion rate of Metolazone which could result in a higher serum level.
Metoprolol	Doxycycline may decrease the excretion rate of Metoprolol which could result in a higher serum level.
Metyrapone	Doxycycline may decrease the excretion rate of Metyrapone which could result in a higher serum level.
Mezlocillin	The therapeutic efficacy of Mezlocillin can be decreased when used in combination with Doxycycline.
Midazolam	Doxycycline may decrease the excretion rate of Midazolam which could result in a higher serum level.
Mifepristone	The serum concentration of Mifepristone can be decreased when it is combined with Doxycycline.
Migalastat	Doxycycline may decrease the excretion rate of Migalastat which could result in a higher serum level.
Milnacipran	Doxycycline may decrease the excretion rate of Milnacipran which could result in a higher serum level.
Milrinone	Milrinone may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Minocycline	The risk or severity of neuromuscular blockade can be increased when Doxycycline is combined with Minocycline.
Mipomersen	Doxycycline may increase the hepatotoxic activities of Mipomersen.
Mirabegron	Doxycycline may decrease the excretion rate of Mirabegron which could result in a higher serum level.
Mivacurium	The therapeutic efficacy of Mivacurium can be increased when used in combination with Doxycycline.
Moxisylyte	Doxycycline may decrease the excretion rate of Moxisylyte which could result in a higher serum level.
Muzolimine	Muzolimine may increase the excretion rate of Doxycycline which could result in a lower serum level and potentially a reduction in efficacy.
Mycophenolate mofetil	Doxycycline may decrease the excretion rate of Mycophenolate mofetil which could result in a higher serum level.
Mycophenolic acid	Doxycycline may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
N-acetyltyrosine	Doxycycline may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Nabumetone	Nabumetone may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Nadolol	Doxycycline may decrease the excretion rate of Nadolol which could result in a higher serum level.
Nadroparin	The risk or severity of bleeding can be increased when Doxycycline is combined with Nadroparin.
Nafcillin	The therapeutic efficacy of Nafcillin can be decreased when used in combination with Doxycycline.
Naldemedine	Doxycycline may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Nalmefene	Doxycycline may decrease the excretion rate of Nalmefene which could result in a higher serum level.
Naloxone	Doxycycline may decrease the excretion rate of Naloxone which could result in a higher serum level.
Naproxen	Naproxen may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Nateglinide	Doxycycline may decrease the excretion rate of Nateglinide which could result in a higher serum level.
Nedaplatin	Doxycycline may decrease the excretion rate of Nedaplatin which could result in a higher serum level.
Nedocromil	Doxycycline may decrease the excretion rate of Nedocromil which could result in a higher serum level.
Nefazodone	Doxycycline may decrease the excretion rate of Nefazodone which could result in a higher serum level.
Neomycin	Doxycycline may decrease the excretion rate of Neomycin which could result in a higher serum level.
Netilmicin	Doxycycline may decrease the excretion rate of Netilmicin which could result in a higher serum level.
Niacinamide ascorbate	The therapeutic efficacy of Doxycycline can be decreased when used in combination with Niacinamide ascorbate.
Nicorandil	Doxycycline may decrease the excretion rate of Nicorandil which could result in a higher serum level.
Nicotine	The risk or severity of adverse effects can be increased when Doxycycline is combined with Nicotine.
Nifedipine	Doxycycline may decrease the excretion rate of Nifedipine which could result in a higher serum level.
Nilutamide	Doxycycline may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Nimesulide	Nimesulide may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Nisoldipine	Doxycycline may decrease the excretion rate of Nisoldipine which could result in a higher serum level.
Nitric Oxide	Doxycycline may decrease the excretion rate of Nitric Oxide which could result in a higher serum level.
Nitrofurantoin	Doxycycline may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Nitroprusside	Doxycycline may decrease the excretion rate of Nitroprusside which could result in a higher serum level.
Nomegestrol	The serum concentration of Nomegestrol can be decreased when it is combined with Doxycycline.
Nomegestrol acetate	The serum concentration of Nomegestrol acetate can be decreased when it is combined with Doxycycline.
Norelgestromin	The serum concentration of Norelgestromin can be decreased when it is combined with Doxycycline.
Norethisterone	The serum concentration of Norethisterone can be decreased when it is combined with Doxycycline.
Norethynodrel	The serum concentration of Norethynodrel can be decreased when it is combined with Doxycycline.
Norgestimate	The serum concentration of Norgestimate can be decreased when it is combined with Doxycycline.
Norgestrel	The serum concentration of Norgestrel can be decreased when it is combined with Doxycycline.
Novobiocin	The therapeutic efficacy of Novobiocin can be increased when used in combination with Doxycycline.
Octinoxate	Doxycycline may decrease the excretion rate of Octinoxate which could result in a higher serum level.
Olsalazine	Olsalazine may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Omeprazole	Omeprazole can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Opium	Doxycycline may decrease the excretion rate of Opium which could result in a higher serum level.
Oseltamivir	Oseltamivir may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Oxacillin	The therapeutic efficacy of Oxacillin can be decreased when used in combination with Doxycycline.
Oxaprozin	Oxaprozin may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Oxazepam	Doxycycline may decrease the excretion rate of Oxazepam which could result in a higher serum level.
Oxetacaine	The risk or severity of methemoglobinemia can be increased when Doxycycline is combined with Oxetacaine.
Oxybenzone	Doxycycline may decrease the excretion rate of Oxybenzone which could result in a higher serum level.
Oxybuprocaine	The risk or severity of methemoglobinemia can be increased when Doxycycline is combined with Oxybuprocaine.
Oxyphenbutazone	Oxyphenbutazone may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Oxyquinoline	Doxycycline may decrease the excretion rate of Oxyquinoline which could result in a higher serum level.
Oxytetracycline	The risk or severity of neuromuscular blockade can be increased when Doxycycline is combined with Oxytetracycline.
Paliperidone	Doxycycline may decrease the excretion rate of Paliperidone which could result in a higher serum level.
Palonosetron	Doxycycline may decrease the excretion rate of Palonosetron which could result in a higher serum level.
Palovarotene	The risk or severity of pseudotumor cerebri can be increased when Doxycycline is combined with Palovarotene.
Pamidronic acid	Pamidronic acid may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Pancuronium	The therapeutic efficacy of Pancuronium can be increased when used in combination with Doxycycline.
Pantoprazole	Pantoprazole can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Parecoxib	Parecoxib may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Parnaparin	The risk or severity of bleeding can be increased when Doxycycline is combined with Parnaparin.
Paromomycin	The risk or severity of neuromuscular blockade can be increased when Doxycycline is combined with Paromomycin.
Patent Blue	Doxycycline may decrease the excretion rate of Patent Blue which could result in a higher serum level.
Pegaptanib	Doxycycline may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Peginesatide	Doxycycline may decrease the excretion rate of Peginesatide which could result in a higher serum level.
Pemetrexed	Doxycycline may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Penbutolol	Doxycycline may decrease the excretion rate of Penbutolol which could result in a higher serum level.
Pentaerythritol tetranitrate	Doxycycline may decrease the excretion rate of Pentaerythritol tetranitrate which could result in a higher serum level.
Pentamidine	Pentamidine may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Pentastarch	Doxycycline may decrease the excretion rate of Pentastarch which could result in a higher serum level.
Pentetic acid	Doxycycline may decrease the excretion rate of Pentetic acid which could result in a higher serum level.
Pentobarbital	The serum concentration of Doxycycline can be decreased when it is combined with Pentobarbital.
Pentolinium	The risk or severity of adverse effects can be increased when Doxycycline is combined with Pentolinium.
Pentosan polysulfate	The risk or severity of bleeding can be increased when Doxycycline is combined with Pentosan polysulfate.
Pentostatin	Doxycycline may decrease the excretion rate of Pentostatin which could result in a higher serum level.
Pentoxifylline	Doxycycline may decrease the excretion rate of Pentoxifylline which could result in a higher serum level.
Perflubutane	Doxycycline can cause a decrease in the absorption of Perflubutane resulting in a reduced serum concentration and potentially a decrease in efficacy.
Perindopril	Doxycycline may decrease the excretion rate of Perindopril which could result in a higher serum level.
Permethrin	Doxycycline may decrease the excretion rate of Permethrin which could result in a higher serum level.
Phenazopyridine	Phenazopyridine may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Phenelzine	Doxycycline may decrease the excretion rate of Phenelzine which could result in a higher serum level.
Pheneticillin	The therapeutic efficacy of Pheneticillin can be decreased when used in combination with Doxycycline.
Phenindione	The risk or severity of bleeding can be increased when Doxycycline is combined with Phenindione.
Phenobarbital	The serum concentration of Doxycycline can be decreased when it is combined with Phenobarbital.
Phenol	The risk or severity of methemoglobinemia can be increased when Doxycycline is combined with Phenol.
Phenoxymethylpenicillin	The therapeutic efficacy of Phenoxymethylpenicillin can be decreased when used in combination with Doxycycline.
Phenprocoumon	The risk or severity of bleeding can be increased when Doxycycline is combined with Phenprocoumon.
Phenylbutazone	Phenylbutazone may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Phenytoin	The serum concentration of Doxycycline can be decreased when it is combined with Phenytoin.
Pholcodine	Doxycycline may decrease the excretion rate of Pholcodine which could result in a higher serum level.
Phosphoric acid	Doxycycline may decrease the excretion rate of Phosphoric acid which could result in a higher serum level.
Phylloquinone	Doxycycline may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Picosulfuric acid	The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Doxycycline.
Pindolol	Doxycycline may decrease the excretion rate of Pindolol which could result in a higher serum level.
Pipecuronium	The therapeutic efficacy of Pipecuronium can be increased when used in combination with Doxycycline.
Piperacillin	The therapeutic efficacy of Piperacillin can be decreased when used in combination with Doxycycline.
Piracetam	Doxycycline may decrease the excretion rate of Piracetam which could result in a higher serum level.
Piretanide	Piretanide may increase the excretion rate of Doxycycline which could result in a lower serum level and potentially a reduction in efficacy.
Piroxicam	Piroxicam may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Pitolisant	Doxycycline may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Pivampicillin	The therapeutic efficacy of Pivampicillin can be decreased when used in combination with Doxycycline.
Pivmecillinam	The therapeutic efficacy of Pivmecillinam can be decreased when used in combination with Doxycycline.
Plazomicin	Doxycycline may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Plerixafor	Doxycycline may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Polythiazide	Polythiazide may increase the excretion rate of Doxycycline which could result in a lower serum level and potentially a reduction in efficacy.
Pomalidomide	Doxycycline may decrease the excretion rate of Pomalidomide which could result in a higher serum level.
Potassium	Potassium may increase the excretion rate of Doxycycline which could result in a lower serum level and potentially a reduction in efficacy.
Potassium acetate	Doxycycline may decrease the excretion rate of Potassium acetate which could result in a higher serum level.
Potassium bicarbonate	Doxycycline may decrease the excretion rate of Potassium bicarbonate which could result in a higher serum level.
Potassium cation	Doxycycline may decrease the excretion rate of Potassium cation which could result in a higher serum level.
Potassium chloride	Doxycycline may decrease the excretion rate of Potassium chloride which could result in a higher serum level.
Potassium citrate	The therapeutic efficacy of Doxycycline can be decreased when used in combination with Potassium citrate.
Potassium nitrate	Doxycycline may decrease the excretion rate of Potassium nitrate which could result in a higher serum level.
Potassium perchlorate	Doxycycline may decrease the excretion rate of Potassium perchlorate which could result in a higher serum level.
Potassium sulfate	Doxycycline may decrease the excretion rate of Potassium sulfate which could result in a higher serum level.
Pralatrexate	Doxycycline may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Pralidoxime	Doxycycline may decrease the excretion rate of Pralidoxime which could result in a higher serum level.
Pramipexole	Doxycycline may decrease the excretion rate of Pramipexole which could result in a higher serum level.
Pramocaine	The risk or severity of methemoglobinemia can be increased when Doxycycline is combined with Pramocaine.
Prasugrel	The risk or severity of bleeding can be increased when Doxycycline is combined with Prasugrel.
Prednisone	Doxycycline may decrease the excretion rate of Prednisone which could result in a higher serum level.
Pregabalin	Pregabalin may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Prilocaine	The risk or severity of methemoglobinemia can be increased when Doxycycline is combined with Prilocaine.
Primidone	The serum concentration of Doxycycline can be decreased when it is combined with Primidone.
Probenecid	Doxycycline may decrease the excretion rate of Probenecid which could result in a higher serum level.
Procainamide	Doxycycline may decrease the excretion rate of Procainamide which could result in a higher serum level.
Procaine	The risk or severity of methemoglobinemia can be increased when Doxycycline is combined with Procaine.
Procaine benzylpenicillin	The therapeutic efficacy of Procaine benzylpenicillin can be decreased when used in combination with Doxycycline.
Progesterone	The serum concentration of Progesterone can be decreased when it is combined with Doxycycline.
Promethazine	Doxycycline may decrease the excretion rate of Promethazine which could result in a higher serum level.
Propantheline	Doxycycline may decrease the excretion rate of Propantheline which could result in a higher serum level.
Proparacaine	The risk or severity of methemoglobinemia can be increased when Doxycycline is combined with Proparacaine.
Propiverine	Doxycycline may decrease the excretion rate of Propiverine which could result in a higher serum level.
Propoxycaine	The risk or severity of methemoglobinemia can be increased when Doxycycline is combined with Propoxycaine.
Propranolol	Doxycycline may decrease the excretion rate of Propranolol which could result in a higher serum level.
Protein C	The risk or severity of bleeding can be increased when Doxycycline is combined with Protein C.
Protein S human	The risk or severity of bleeding can be increased when Doxycycline is combined with Protein S human.
Prucalopride	Doxycycline may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Prussian blue	Doxycycline can cause a decrease in the absorption of Prussian blue resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pyrantel	The therapeutic efficacy of Pyrantel can be increased when used in combination with Doxycycline.
Pyrazinamide	Doxycycline may decrease the excretion rate of Pyrazinamide which could result in a higher serum level.
Pyridoxine	Pyridoxine may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Quetiapine	Doxycycline may decrease the excretion rate of Quetiapine which could result in a higher serum level.
Quinapril	Quinapril can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Quinethazone	Quinethazone may increase the excretion rate of Doxycycline which could result in a lower serum level and potentially a reduction in efficacy.
Quinidine	Doxycycline may decrease the excretion rate of Quinidine which could result in a higher serum level.
Quinine	The risk or severity of neuromuscular blockade can be increased when Doxycycline is combined with Quinine.
Rabeprazole	Rabeprazole can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ramelteon	Doxycycline may decrease the excretion rate of Ramelteon which could result in a higher serum level.
Ranitidine	Doxycycline may decrease the excretion rate of Ranitidine which could result in a higher serum level.
Ranolazine	Ranolazine may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Rapacuronium	The therapeutic efficacy of Rapacuronium can be increased when used in combination with Doxycycline.
Rasagiline	Doxycycline may decrease the excretion rate of Rasagiline which could result in a higher serum level.
Reserpine	Reserpine may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Resorcinol	Doxycycline may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Reteplase	The risk or severity of bleeding can be increased when Doxycycline is combined with Reteplase.
Reviparin	The risk or severity of bleeding can be increased when Doxycycline is combined with Reviparin.
Ribavirin	Doxycycline may decrease the excretion rate of Ribavirin which could result in a higher serum level.
Ribostamycin	Doxycycline may decrease the excretion rate of Ribostamycin which could result in a higher serum level.
Rivaroxaban	The risk or severity of bleeding can be increased when Doxycycline is combined with Rivaroxaban.
Rizatriptan	Doxycycline may decrease the excretion rate of Rizatriptan which could result in a higher serum level.
Rocuronium	The therapeutic efficacy of Rocuronium can be increased when used in combination with Doxycycline.
Rofecoxib	Rofecoxib may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Roflumilast	Doxycycline may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Rolitetracycline	The risk or severity of neuromuscular blockade can be increased when Doxycycline is combined with Rolitetracycline.
Ropivacaine	The risk or severity of methemoglobinemia can be increased when Doxycycline is combined with Ropivacaine.
Rosiglitazone	Doxycycline may decrease the excretion rate of Rosiglitazone which could result in a higher serum level.
Ruxolitinib	Doxycycline may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Sacubitril	Doxycycline may decrease the excretion rate of Sacubitril which could result in a higher serum level.
Salicylamide	Salicylamide may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Salicylic acid	Salicylic acid may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Salmon calcitonin	Salmon calcitonin may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Salsalate	Salsalate may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Saxagliptin	Doxycycline may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Secobarbital	The serum concentration of Doxycycline can be decreased when it is combined with Secobarbital.
Selenious acid	Doxycycline may decrease the excretion rate of Selenious acid which could result in a higher serum level.
Selenium	Doxycycline may decrease the excretion rate of Selenium which could result in a higher serum level.
Sevelamer	Sevelamer can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sibutramine	Doxycycline may decrease the excretion rate of Sibutramine which could result in a higher serum level.
Sitagliptin	Doxycycline may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Sodium acetate	Doxycycline may decrease the excretion rate of Sodium acetate which could result in a higher serum level.
Sodium ascorbate	The therapeutic efficacy of Doxycycline can be decreased when used in combination with Sodium ascorbate.
Sodium aurothiomalate	Doxycycline may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level.
Sodium bicarbonate	Sodium bicarbonate can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sodium citrate	The risk or severity of bleeding can be increased when Doxycycline is combined with Sodium citrate.
Sodium feredetate	Doxycycline can cause a decrease in the absorption of Sodium feredetate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sodium fluoride	Doxycycline may decrease the excretion rate of Sodium fluoride which could result in a higher serum level.
Sodium sulfate	Doxycycline may decrease the excretion rate of Sodium sulfate which could result in a higher serum level.
Sofosbuvir	Doxycycline may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Solriamfetol	Doxycycline may decrease the excretion rate of Solriamfetol which could result in a higher serum level.
Sorafenib	Doxycycline may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Sorbitol	Doxycycline may decrease the excretion rate of Sorbitol which could result in a higher serum level.
Spironolactone	Spironolactone may increase the excretion rate of Doxycycline which could result in a lower serum level and potentially a reduction in efficacy.
Stiripentol	Doxycycline may decrease the excretion rate of Stiripentol which could result in a higher serum level.
Streptokinase	The risk or severity of bleeding can be increased when Doxycycline is combined with Streptokinase.
Streptomycin	Doxycycline may decrease the excretion rate of Streptomycin which could result in a higher serum level.
Strontium chloride	Doxycycline may decrease the excretion rate of Strontium chloride which could result in a higher serum level.
Strontium ranelate	The serum concentration of Doxycycline can be decreased when it is combined with Strontium ranelate.
Succinylcholine	The therapeutic efficacy of Succinylcholine can be increased when used in combination with Doxycycline.
Sucralfate	Sucralfate can cause a decrease in the absorption of Doxycycline resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sulbactam	Doxycycline may decrease the excretion rate of Sulbactam which could result in a higher serum level.
Sulfadiazine	Doxycycline may decrease the excretion rate of Sulfadiazine which could result in a higher serum level.
Sulfamethoxazole	Doxycycline may decrease the excretion rate of Sulfamethoxazole which could result in a higher serum level.
Sulfasalazine	Sulfasalazine may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Sulindac	Sulindac may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Sulodexide	The risk or severity of bleeding can be increased when Doxycycline is combined with Sulodexide.
Sultamicillin	The therapeutic efficacy of Sultamicillin can be decreased when used in combination with Doxycycline.
Sumatriptan	Doxycycline may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
Synthetic Conjugated Estrogens, A	Doxycycline may decrease the excretion rate of Synthetic Conjugated Estrogens, A which could result in a higher serum level.
Synthetic Conjugated Estrogens, B	Doxycycline may decrease the excretion rate of Synthetic Conjugated Estrogens, B which could result in a higher serum level.
Tacrolimus	Tacrolimus may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Tadalafil	Doxycycline may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Talc	The absorption of Doxycycline can be decreased when combined with Talc.
Tamsulosin	Doxycycline may decrease the excretion rate of Tamsulosin which could result in a higher serum level.
Tasimelteon	Doxycycline may decrease the excretion rate of Tasimelteon which could result in a higher serum level.
Tazarotene	The risk or severity of pseudotumor cerebri can be increased when Tazarotene is combined with Doxycycline.
Technetium Tc-99m exametazime	Doxycycline may decrease the excretion rate of Technetium Tc-99m exametazime which could result in a higher serum level.
Technetium Tc-99m mebrofenin	Doxycycline may decrease the excretion rate of Technetium Tc-99m mebrofenin which could result in a higher serum level.
Technetium Tc-99m oxidronate	Doxycycline may decrease effectiveness of Technetium Tc-99m oxidronate as a diagnostic agent.
Technetium Tc-99m pyrophosphate	Doxycycline may decrease the excretion rate of Technetium Tc-99m pyrophosphate which could result in a higher serum level.
Teduglutide	Doxycycline may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Tegafur	Doxycycline may decrease the excretion rate of Tegafur which could result in a higher serum level.
Telavancin	Doxycycline may decrease the excretion rate of Telavancin which could result in a higher serum level.
Temazepam	Temazepam may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Temocillin	The therapeutic efficacy of Temocillin can be decreased when used in combination with Doxycycline.
Temozolomide	Doxycycline may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Tenecteplase	The risk or severity of bleeding can be increased when Doxycycline is combined with Tenecteplase.
Tenofovir alafenamide	The serum concentration of Tenofovir alafenamide can be increased when it is combined with Doxycycline.
Tenofovir disoproxil	Tenofovir disoproxil may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Tenoxicam	Tenoxicam may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Terbutaline	Doxycycline may decrease the excretion rate of Terbutaline which could result in a higher serum level.
Testolactone	Doxycycline may decrease the excretion rate of Testolactone which could result in a higher serum level.
Testosterone	Doxycycline may decrease the excretion rate of Testosterone which could result in a higher serum level.
Testosterone cypionate	Doxycycline may decrease the excretion rate of Testosterone cypionate which could result in a higher serum level.
Testosterone enanthate	Doxycycline may decrease the excretion rate of Testosterone enanthate which could result in a higher serum level.
Testosterone propionate	Doxycycline may decrease the excretion rate of Testosterone propionate which could result in a higher serum level.
Testosterone undecanoate	Doxycycline may decrease the excretion rate of Testosterone undecanoate which could result in a higher serum level.
Tetracaine	The risk or severity of methemoglobinemia can be increased when Doxycycline is combined with Tetracaine.
Tetracycline	The risk or severity of neuromuscular blockade can be increased when Doxycycline is combined with Tetracycline.
Tetradecyl hydrogen sulfate (ester)	Doxycycline may decrease the excretion rate of Tetradecyl hydrogen sulfate (ester) which could result in a higher serum level.
Tetraferric tricitrate decahydrate	Doxycycline can cause a decrease in the absorption of Tetraferric tricitrate decahydrate resulting in a reduced serum concentration and potentially a decrease in efficacy.
Thiabendazole	Doxycycline may decrease the excretion rate of Thiabendazole which could result in a higher serum level.
Thiamylal	The serum concentration of Doxycycline can be decreased when it is combined with Thiamylal.
Thiethylperazine	Doxycycline may decrease the excretion rate of Thiethylperazine which could result in a higher serum level.
Thiopental	The serum concentration of Doxycycline can be decreased when it is combined with Thiopental.
Tiaprofenic acid	Tiaprofenic acid may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Ticagrelor	The risk or severity of bleeding can be increased when Doxycycline is combined with Ticagrelor.
Ticarcillin	The therapeutic efficacy of Ticarcillin can be decreased when used in combination with Doxycycline.
Ticlopidine	Ticlopidine may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Tigecycline	The risk or severity of neuromuscular blockade can be increased when Doxycycline is combined with Tigecycline.
Tiludronic acid	Doxycycline may decrease the excretion rate of Tiludronic acid which could result in a higher serum level.
Timolol	Doxycycline may decrease the excretion rate of Timolol which could result in a higher serum level.
Tinidazole	Doxycycline may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Tinzaparin	The risk or severity of bleeding can be increased when Doxycycline is combined with Tinzaparin.
Tiopronin	Doxycycline may decrease the excretion rate of Tiopronin which could result in a higher serum level.
Tiotropium	Doxycycline may decrease the excretion rate of Tiotropium which could result in a higher serum level.
Tirofiban	Doxycycline may decrease the excretion rate of Tirofiban which could result in a higher serum level.
Tixocortol	Doxycycline may decrease the excretion rate of Tixocortol which could result in a higher serum level.
Tobramycin	Doxycycline may decrease the excretion rate of Tobramycin which could result in a higher serum level.
Tocopherol	Doxycycline may decrease the excretion rate of Tocopherol which could result in a higher serum level.
Tolazamide	Doxycycline may decrease the excretion rate of Tolazamide which could result in a higher serum level.
Tolbutamide	Doxycycline may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Tolcapone	Doxycycline may decrease the excretion rate of Tolcapone which could result in a higher serum level.
Tolfenamic acid	Tolfenamic acid may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Tolmetin	Tolmetin may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Tolterodine	Doxycycline may decrease the excretion rate of Tolterodine which could result in a higher serum level.
Tolvaptan	Tolvaptan may increase the excretion rate of Doxycycline which could result in a lower serum level and potentially a reduction in efficacy.
Topiramate	Doxycycline may decrease the excretion rate of Topiramate which could result in a higher serum level.
Topotecan	Doxycycline may decrease the excretion rate of Topotecan which could result in a higher serum level.
Torasemide	Torasemide may increase the excretion rate of Doxycycline which could result in a lower serum level and potentially a reduction in efficacy.
Tositumomab	Tositumomab may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Tramadol	Tramadol may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Trametinib	Doxycycline may decrease the excretion rate of Trametinib which could result in a higher serum level.
Tretinoin	The risk or severity of pseudotumor cerebri can be increased when Tretinoin is combined with Doxycycline.
Triamterene	Triamterene may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Triazolam	Doxycycline may decrease the excretion rate of Triazolam which could result in a higher serum level.
Trichlormethiazide	Trichlormethiazide may increase the excretion rate of Doxycycline which could result in a lower serum level and potentially a reduction in efficacy.
Triethylenetetramine	Doxycycline may decrease the excretion rate of Triethylenetetramine which could result in a higher serum level.
Trifluridine	Doxycycline may decrease the excretion rate of Trifluridine which could result in a higher serum level.
Triflusal	The risk or severity of bleeding can be increased when Doxycycline is combined with Triflusal.
Trimebutine	Doxycycline may decrease the excretion rate of Trimebutine which could result in a higher serum level.
Trimethaphan	The risk or severity of adverse effects can be increased when Doxycycline is combined with Trimethaphan.
Trimethoprim	Doxycycline may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Trimetrexate	Doxycycline may decrease the excretion rate of Trimetrexate which could result in a higher serum level.
Trioxsalen	The therapeutic efficacy of Trioxsalen can be increased when used in combination with Doxycycline.
Tropisetron	Doxycycline may decrease the excretion rate of Tropisetron which could result in a higher serum level.
Tubocurarine	The therapeutic efficacy of Tubocurarine can be increased when used in combination with Doxycycline.
Typhoid vaccine	The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Doxycycline.
Ulipristal	The serum concentration of Ulipristal can be decreased when it is combined with Doxycycline.
Urokinase	The risk or severity of bleeding can be increased when Doxycycline is combined with Urokinase.
Vaborbactam	Doxycycline may decrease the excretion rate of Vaborbactam which could result in a higher serum level.
Valaciclovir	Valaciclovir may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Valbenazine	Doxycycline may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Valdecoxib	Valdecoxib may decrease the excretion rate of Doxycycline which could result in a higher serum level.
Valganciclovir	Doxycycline may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Vancomycin	Doxycycline may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Varenicline	Doxycycline may decrease the excretion rate of Varenicline which could result in a higher serum level.
Vecuronium	The therapeutic efficacy of Vecuronium can be increased when used in combination with Doxycycline.
Venlafaxine	Doxycycline may decrease the excretion rate of Venlafaxine which could result in a higher serum level.
Verapamil	Doxycycline may decrease the excretion rate of Verapamil which could result in a higher serum level.
Vibrio cholerae CVD 103-HgR strain live antigen	The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Doxycycline.
Vilanterol	Doxycycline may decrease the excretion rate of Vilanterol which could result in a higher serum level.
Viloxazine	Doxycycline may decrease the excretion rate of Viloxazine which could result in a higher serum level.
Viomycin	The risk or severity of neuromuscular blockade can be increased when Doxycycline is combined with Viomycin.
Vitamin A	The risk or severity of pseudotumor cerebri can be increased when Vitamin A is combined with Doxycycline.
Vorapaxar	The risk or severity of bleeding can be increased when Doxycycline is combined with Vorapaxar.
Vortioxetine	Doxycycline may decrease the excretion rate of Vortioxetine which could result in a higher serum level.
Warfarin	The risk or severity of bleeding can be increased when Doxycycline is combined with Warfarin.
Ximelagatran	The risk or severity of bleeding can be increased when Doxycycline is combined with Ximelagatran.
Zaleplon	Doxycycline may decrease the excretion rate of Zaleplon which could result in a higher serum level.
Zanamivir	Doxycycline may decrease the excretion rate of Zanamivir which could result in a higher serum level.
Zinc ascorbate	The therapeutic efficacy of Doxycycline can be decreased when used in combination with Zinc ascorbate.
Zonisamide	Doxycycline may decrease the excretion rate of Zonisamide which could result in a higher serum level.

Food Interactions

Avoid multivalent ions. The absorption of tetracyclines is reduced when taken with foods, especially those which contain calcium.
Take with or without food. The absorption of tetracyclines is reduced when taken with foods, but not to a significant extent. If gastric irritation occurs, it is recommended that doxycycline be given with food or milk.

Products

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Product Ingredients

Ingredient	UNII	CAS	InChI Key
Doxycycline calcium	8ZL07I20SB	94088-85-4	IYECPECUTCOMMD-QFWOMMJSSA-N
Doxycycline hyclate	19XTS3T51U	24390-14-5	HALQELOKLVRWRI-VDBOFHIQSA-N
Doxycycline hydrochloride	4182Z6T2ET	10592-13-9	RUYHIJHUVHIMIR-CVHRZJFOSA-N
Doxycycline monohydrate	N12000U13O	17086-28-1	XQTWDDCIUJNLTR-CVHRZJFOSA-N

Product Images

International/Other Brands

Doxy (Galpharma) / Doxycin (Laboratoire Riva) / Doxylin (Actavis) / Jenacyclin / Microdox (Micro Labs) / NicAzelDoxyKit / Nu-Doxycycline (Nu-Pharm) / Supracyclin (Grünenthal) / Vibramycin (Pfizer)

Brand Name Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Acticlate	Tablet, coated	150 mg/1	Oral	Almirall, LLC	2014-07-28	Not applicable
Acticlate	Tablet, coated	75 mg/1	Oral	Almirall, LLC	2014-07-28	Not applicable
Acticlate CAP	Capsule	75 mg/1	Oral	Aqua Pharmaceuticals	2018-05-31	Not applicable
Apprilon		40 mg	Oral	Galderma	2012-11-29	Not applicable
Atridox	Kit	50 mg/1	Oral	Den-mat Holdings, Llc	2016-12-01	2021-12-31
Atridox		8.8 % w/w	Oral	Den Mat Holdings, Llc	2001-01-31	Not applicable
Atridox	Kit	50 mg/500mg	Oral	TOLMAR Inc.	1998-09-03	2018-10-01
Doryx	Tablet, delayed release	150 mg/1	Oral	Allergan	2011-09-21	2013-01-31
Doryx	Tablet, delayed release	75 mg/1	Oral	Warner Chilcott (US), Inc.	2007-03-20	2007-03-20
Doryx	Capsule, delayed release pellets	75 mg/1	Oral	Allergan	1985-09-01	2006-09-30
Doryx	Capsule, delayed release pellets	75 mg/1	Oral	Warner Chilcott (US), Inc.	2007-08-02	Not applicable
Doryx	Tablet, delayed release	200 mg/1	Oral	Mayne Pharma Commercial LLC	2015-04-13	2025-04-30
Doryx	Tablet, delayed release	100 mg/1	Oral	Allergan	2005-09-01	2011-08-01
Doryx	Capsule, delayed release pellets	100 mg/1	Oral	Physicians Total Care, Inc.	1985-07-22	2000-09-19
Doryx	Tablet, delayed release	80 mg/1	Oral	Mayne Pharma Commercial LLC	2020-10-02	2023-01-31
Doryx	Capsule, delayed release pellets	100 mg/1	Oral	Warner Chilcott (US), Inc.	2007-08-02	Not applicable
Doryx	Tablet, delayed release	200 mg/1	Oral	Allergan	2013-07-01	2016-04-30
Doryx	Capsule, delayed release pellets	100 mg/1	Oral	Allergan	1985-09-01	2007-08-30
Doryx	Tablet, delayed release	150 mg/1	Oral	Warner Chilcott (US), LLC	2008-07-01	2009-08-01
Doryx	Tablet, delayed release	50 mg/1	Oral	Mayne Pharma Commercial LLC	2015-05-26	2024-01-31
Doryx 100mg Cap	Capsule, extended release	100 mg / cap	Oral	Parke Davis Division, Warner Lambert Canada Inc.	1991-12-31	1998-09-14
Doryx Mpc	Tablet, delayed release	120 mg/1	Oral	Mayne Pharma Commercial LLC	2016-07-01	2024-06-30
Doryx Mpc	Tablet, delayed release	60 mg/1	Oral	Mayne Pharma Commercial LLC	2023-01-02	Not applicable
Doxycin Cap 100mg	Capsule	100 mg	Oral	Laboratoire Riva Inc	1989-12-31	Not applicable
Doxycin Tab 100mg	Tablet	100 mg	Oral	Laboratoire Riva Inc	1989-12-31	Not applicable
Doxycycline	Tablet, film coated	50 mg/1	Oral	Mylan Pharmaceuticals Inc.	2008-01-28	2008-01-28
Doxycycline	Tablet, film coated	75 mg/1	Oral	Mylan Pharmaceuticals Inc.	2008-01-28	2008-01-28
Doxycycline	Tablet, film coated	100 mg/1	Oral	Blessings International	2008-05-01	Not applicable
Doxycycline Capsules	Capsule	100 mg	Oral	Sanis Health Inc	2010-06-15	Not applicable
Doxycycline Hyclate	Tablet, film coated	75 mg/1	Oral	Actavis Pharma, Inc.	2017-06-19	Not applicable
Doxycycline Hyclate	Tablet	100 mg/1	Oral	Watson Pharmaceuticals	2006-05-11	2006-08-14
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Watson Pharmaceuticals	2006-05-11	2006-08-14
Doxycycline Hyclate	Tablet, film coated	150 mg/1	Oral	Actavis Pharma, Inc.	2017-06-19	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Watson Pharmaceuticals	2006-05-11	2006-08-14
Doxycycline Monohydrate	Tablet	150 mg/1	Oral	Doak Dermatologics	2007-02-09	Not applicable
Doxycycline Monohydrate	Capsule	75 mg/1	Oral	Chartwell Rx, Llc.	1989-12-29	Not applicable
Doxycycline Monohydrate	Tablet	50 mg/1	Oral	Doak Dermatologics	2007-02-09	Not applicable
Doxycycline Monohydrate	Tablet	75 mg/1	Oral	Doak Dermatologics	2007-02-09	Not applicable
Doxycycline Monohydrate	Capsule	150 mg/1	Oral	Chartwell Rx, Llc.	1989-12-29	Not applicable
Doxycycline Monohydrate	Capsule	50 mg/1	Oral	Chartwell Rx, Llc.	1989-12-29	Not applicable
Doxycycline Monohydrate	Capsule	100 mg/1	Oral	RedPharm Drug, Inc.	2018-01-01	Not applicable
Doxycycline Monohydrate	Tablet	100 mg/1	Oral	Doak Dermatologics	2007-02-09	Not applicable
Doxycycline Monohydrate	Capsule	100 mg/1	Oral	Chartwell Rx, Llc.	1989-12-29	Not applicable
Doxycycline Tablets	Tablet	100 mg	Oral	Sanis Health Inc	2010-06-15	Not applicable
Doxycycline-100 Cap 100mg USP	Capsule	100 mg / cap	Oral	Pro Doc Limitee	1987-12-31	2010-07-13
Doxytab	Tablet	100 mg	Oral	Pro Doc Limitee	1990-12-31	Not applicable
LymePak	Tablet, film coated	100 mg/1	Oral	Chartwell Rx, Llc.	2020-04-01	Not applicable
LymePak	Tablet, film coated	100 mg/1	Oral	Lifsa Drugs Llc	2021-09-10	Not applicable
LymePak	Tablet, film coated	100 mg/1	Oral	Chartwell Branded, LLC	2018-06-15	2018-06-15
M-doxycycline	Tablet	100 mg	Oral	Mantra Pharma Inc	Not applicable	Not applicable
Monodox	Capsule	75 mg/1	Oral	Aqua Pharmaceuticals	2007-01-31	Not applicable
Monodox	Capsule	50 mg/1	Oral	Watson Pharma, Inc.	1989-12-29	2012-02-16
Monodox	Capsule	50 mg/1	Oral	Aqua Pharmaceuticals	1992-02-10	Not applicable
Monodox	Capsule	100 mg/1	Oral	Aqua Pharmaceuticals	1989-12-29	Not applicable
Monodox	Capsule	100 mg/1	Oral	Watson Pharma, Inc.	1989-12-29	2012-02-16
Oracea	Capsule	40 mg/1	Oral	Galderma Laboratories, L.P.	2010-05-14	Not applicable
Oracea	Capsule, delayed release pellets	40 mg/1	Oral	Galderma	2006-05-27	2010-07-31
Periostat	Tablet	20 mg/1	Oral	Galderma	2001-02-03	2011-12-31
Periostat	Tablet	20 mg/1	Oral	Galderma	1998-09-30	2010-06-30
Periostat	Capsule	20 mg	Oral	Pendopharm Division Of Pharmascience Inc	2003-09-03	Not applicable
Prz-doxycycline	Tablet	100 mg	Oral	Pharmaris Canada Inc	2023-09-01	Not applicable
Vibra-Tabs	Tablet, film coated	100 mg/1	Oral	Pfizer Laboratories Div Pfizer Inc	1980-01-15	2010-10-01
Vibra-Tabs	Tablet	100 mg	Oral	Pfizer Canada Ulc	1986-12-31	2014-04-04
Vibramycin Calcium	Syrup	50 mg/5mL	Oral	Pfizer Laboratories Div Pfizer Inc	1974-09-23	Not applicable
Vibramycin Cap 100mg	Capsule	100 mg	Oral	Pfizer Canada Ulc	1969-12-31	2016-04-04
Vibramycin Hyclate	Capsule	50 mg/1	Oral	UNSPECIFIED	2006-01-27	2006-01-27
Vibramycin Hyclate	Capsule	100 mg/1	Oral	Pfizer Laboratories Div Pfizer Inc	1967-12-05	Not applicable
Vibramycin Inj	Powder	100 mg / vial	Intravenous	Pfizer Canada Ulc	1997-07-25	2000-07-26
Vibramycin Monohydrate	Powder, for suspension	25 mg/5mL	Oral	Pfizer Laboratories Div Pfizer Inc	1967-12-06	Not applicable

Generic Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Adoxa	Capsule	150 mg/1	Oral	Pharma Derm, A Division Of Fougera Pharmaceuticals Inc.	2011-06-01	Not applicable
Alodox	Tablet	20 mg/1	Oral	OCuSOFT Inc.	2008-10-01	2015-06-30
Alti-doxycycline - Tab 100mg	Tablet	100 mg / tab	Oral	Altimed Pharma Inc.	1995-12-31	2001-09-05
Alti-doxycycline-cap 100mg	Capsule	100 mg / cap	Oral	Altimed Pharma Inc.	1995-12-31	2001-09-05
Apo-doxy Cap 100mg	Capsule	100 mg	Oral	Apotex Corporation	1987-12-31	Not applicable
Apo-doxy Tabs 100mg	Tablet	100 mg	Oral	Apotex Corporation	1990-12-31	Not applicable
Apo-doxycycline Modified Release	Capsule, extended release	40 mg	Oral	Apotex Corporation	Not applicable	Not applicable
Apo-doxycycline Mr		40 mg	Oral	Apotex Corporation	2021-09-01	Not applicable
Dom-doxycycline	Capsule	100 mg	Oral	Dominion Pharmacal	2008-04-16	2016-10-25
Dom-doxycycline	Tablet	100 mg	Oral	Dominion Pharmacal	2008-04-16	2016-10-25
Doxy 100	Injection, powder, lyophilized, for solution	100 mg/10mL	Intravenous	General Injectables & Vaccines, Inc	2012-02-22	2021-09-30
Doxy 100	Injection, powder, lyophilized, for solution	100 mg/10mL	Intravenous	Fresenius Kabi USA, LLC	2000-10-17	Not applicable
Doxy 100(tm) Doxycycline	Injection, powder, lyophilized, for solution	100 mg/10mL	Intravenous	HF Acquisition Co LLC, DBA HealthFirst	2019-10-07	Not applicable
Doxycyclate Hyclate	Capsule	100 mg/1	Oral	Liberty Pharmaceuticals, Inc.	1990-09-01	Not applicable
Doxycyclate Hyclate	Capsule	100 mg/1	Oral	Golden State Medical Supply	2002-12-09	2016-02-22
Doxycyclate Hyclate	Capsule	100 mg/1	Oral	REMEDYREPACK INC.	2018-11-02	Not applicable
Doxycyclate Hyclate	Capsule	50 mg/1	Oral	Golden State Medical Supply	2002-12-09	2016-02-22
Doxycycline	Tablet, film coated	75 mg/1	Oral	Lannett Company, Inc.	2008-08-25	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Zydus Pharmaceuticals USA Inc.	2016-03-14	Not applicable
Doxycycline	Capsule	50 mg/1	Oral	Cosette Pharmaceuticals, Inc.	2015-05-28	Not applicable
Doxycycline	Capsule	50 mg/1	Oral	Mayne Pharma Inc.	2018-03-09	2019-11-30
Doxycycline	Tablet, film coated	100 mg/1	Oral	Proficient Rx LP	2018-01-11	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Remedy Repack	2015-04-22	2016-12-02
Doxycycline	Capsule	100 mg/1	Oral	Alembic Pharmaceuticals Limited	2017-07-31	Not applicable
Doxycycline	Capsule	50 mg/1	Oral	Sun Pharmaceutical Industries, Inc.	2000-12-26	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	medsource pharmaceuticals	2021-11-19	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	RedPharm Drug, Inc.	2018-01-01	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Nucare Pharmaceuticals,inc.	2022-08-01	Not applicable
Doxycycline	Tablet	100 mg/1	Oral	KAISER FOUNDATION HOSPITALS	2014-04-28	2017-08-31
Doxycycline	Powder, for suspension	25 mg/5mL	Oral	Harris Pharmaceutical, Inc	2008-07-16	2019-02-28
Doxycycline	Tablet, coated	100 mg/1	Oral	Aidarex Pharmaceuticals LLC	2003-07-02	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	bryant ranch prepack	2021-11-19	Not applicable
Doxycycline	Capsule	50 mg/1	Oral	PD-Rx Pharmaceuticals, Inc.	2015-05-28	2019-09-30
Doxycycline	Capsule	100 mg/1	Oral	Denton Pharma, Inc. Dba Northwind Pharmaceuticals	2020-02-19	2024-02-29
Doxycycline	Tablet, film coated	50 mg/1	Oral	Sun Pharmaceutical Industries Limited	2018-08-06	Not applicable
Doxycycline	Powder, for suspension	25 mg/5mL	Oral	Chartwell RX LLC	2008-07-16	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	PD-Rx Pharmaceuticals, Inc.	2000-12-26	Not applicable
Doxycycline	Capsule	50 mg/1	Oral	Strides Pharma Science Limited	2022-08-01	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	REMEDYREPACK INC.	2013-04-29	2017-03-06
Doxycycline	Tablet, coated	100 mg/1	Oral	A-S Medication Solutions	2003-07-02	2016-05-31
Doxycycline	Capsule	100 mg/1	Oral	Zydus Lifesciences Limited	2016-03-14	Not applicable
Doxycycline	Tablet	100 mg/1	Oral	Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.	2012-05-01	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Par Pharmaceutical, Inc.	2000-12-01	2024-12-31
Doxycycline	Tablet, coated	100 mg/1	Oral	Mesource Pharmaceuticals	2003-07-02	2015-01-30
Doxycycline	Injection, powder, lyophilized, for solution	200 mg/20mL	Intravenous	Zydus Lifesciences Limited	2018-02-01	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Rpk Pharmaceuticals, Inc.	2022-08-01	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Proficient Rx LP	2015-05-28	Not applicable
Doxycycline	Injection, powder, lyophilized, for solution	100 mg/10mL	Intravenous	Mylan Institutional LLC	2018-12-20	Not applicable
Doxycycline	Tablet, coated	100 mg/1	Oral	PuraCap Laboratories LLC	2010-05-01	2014-11-30
Doxycycline	Tablet, film coated	50 mg/1	Oral	Eon Labs, Inc.	2006-11-27	2014-06-01
Doxycycline	Capsule	100 mg/1	Oral	A-S Medication Solutions	2000-12-26	Not applicable
Doxycycline	Tablet, film coated	100 mg/1	Oral	KAISER FOUNDATION HOSPITALS	2013-03-14	2020-07-31
Doxycycline	Capsule	75 mg/1	Oral	Gw Pharmaceuticals Ltd.	2015-05-28	2019-09-30
Doxycycline	Capsule	100 mg/1	Oral	Eon Labs, Inc.	2000-06-30	2012-03-31
Doxycycline	Tablet, film coated	100 mg/1	Oral	Elorac, Inc.	2005-12-08	Not applicable
Doxycycline	Tablet, coated	100 mg/1	Oral	Cardinal Health 107, LLC	2003-07-02	Not applicable
Doxycycline	Tablet, film coated	100 mg/1	Oral	Sun Pharmaceutical Industries Limited	2018-08-06	Not applicable
Doxycycline	Tablet	100 mg/1	Oral	Chartwell Rx, Llc	2012-05-01	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	bryant ranch prepack	2015-05-28	2019-07-31
Doxycycline	Tablet, coated	100 mg/1	Oral	Northwind Pharmaceuticals, LLC	2023-02-27	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Direct Rx	2016-03-17	Not applicable
Doxycycline	Tablet, film coated	100 mg/1	Oral	Denton Pharma, Inc. Dba Northwind Pharmaceuticals	2019-03-25	Not applicable
Doxycycline	Tablet, coated	100 mg/1	Oral	American Health Packaging	2013-03-01	Not applicable
Doxycycline	Capsule	75 mg/1	Oral	Alembic Pharmaceuticals Inc.	2017-07-31	Not applicable
Doxycycline	Capsule	50 mg/1	Oral	Novel Laboratories, Inc.	2015-05-28	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	RedPharm Drug, Inc.	2015-05-28	Not applicable
Doxycycline	Powder, for suspension	25 mg/5mL	Oral	Teva	2011-02-11	2011-02-28
Doxycycline	Capsule	150 mg/1	Oral	Mylan Pharmaceuticals Inc.	2012-06-12	2020-01-31
Doxycycline	Capsule	40 mg/1	Oral	Owen Laboratories, Inc.	2010-05-14	2017-12-31
Doxycycline	Capsule	100 mg/1	Oral	Denton Pharma, Inc. Dba Northwind Pharmaceuticals	2018-10-30	Not applicable
Doxycycline	Tablet	150 mg/1	Oral	Strides Pharma Science Limited	2022-09-19	Not applicable
Doxycycline	Tablet, film coated	100 mg/1	Oral	REMEDYREPACK INC.	2023-07-21	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	bryant ranch prepack	2015-02-20	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	bryant ranch prepack	2000-12-01	2018-05-30
Doxycycline	Capsule	100 mg/1	Oral	Tris Pharma Inc	2021-11-19	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Remedy Repack	2015-12-18	2016-02-03
Doxycycline	Capsule	50 mg/1	Oral	REMEDYREPACK INC.	2022-02-14	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	bryant ranch prepack	2015-05-28	2022-10-31
Doxycycline	Capsule	100 mg/1	Oral	Sun Pharmaceutical Industries, Inc.	2000-12-26	Not applicable
Doxycycline	Capsule	40 mg/1	Oral	Lupin Pharmaceuticals, Inc.	2024-04-08	Not applicable
Doxycycline	Capsule	50 mg/1	Oral	Golden State Medical Supply, Inc.	2000-12-01	2024-11-30
Doxycycline	Capsule	100 mg/1	Oral	H.j. Harkins Co., Inc.	2017-12-04	Not applicable
Doxycycline	Tablet, film coated	75 mg/1	Oral	Zydus Lifesciences Limited	2018-01-11	Not applicable
Doxycycline	Tablet, coated	100 mg/1	Oral	Keltman Pharmaceuticals Inc.	2011-01-10	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	RedPharm Drug, Inc.	2020-01-01	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Proficient Rx LP	2016-03-14	Not applicable
Doxycycline	Tablet, film coated	100 mg/1	Oral	A-S Medication Solutions	2018-01-11	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Rpk Pharmaceuticals, Inc.	2015-05-28	Not applicable
Doxycycline	Tablet, coated	100 mg/1	Oral	A-S Medication Solutions	2003-07-02	2018-09-30
Doxycycline	Capsule	50 mg/1	Oral	bryant ranch prepack	2016-03-14	Not applicable
Doxycycline	Powder, for suspension	25 mg/5mL	Oral	Chartwell Governmental & Specialty RX, LLC	2008-07-16	Not applicable
Doxycycline	Tablet, coated	100 mg/1	Oral	Cardinal Health	2003-07-02	2015-01-31
Doxycycline	Capsule	100 mg/1	Oral	Aidarex Pharmaceuticals LLC	2014-04-14	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Nucare Pharmaceuticals,inc.	2015-05-28	Not applicable
Doxycycline	Injection, powder, lyophilized, for solution	200 mg/20mL	Intravenous	Zydus Pharmaceuticals USA Inc.	2018-02-01	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Rpk Pharmaceuticals, Inc.	2016-04-29	Not applicable
Doxycycline	Tablet, film coated	100 mg/1	Oral	Eon Labs, Inc.	2006-11-27	2014-06-01
Doxycycline	Tablet, coated	100 mg/1	Oral	Golden State Medical Supply, Inc.	2003-07-02	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	bryant ranch prepack	2015-05-28	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	PD-Rx Pharmaceuticals, Inc.	2000-12-26	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Cosette Pharmaceuticals, Inc.	2015-05-28	2022-10-31
Doxycycline	Capsule	100 mg/1	Oral	RedPharm Drug	2021-11-19	Not applicable
Doxycycline	Tablet	75 mg/1	Oral	Par Pharmaceutical, Inc.	2000-12-15	2020-03-31
Doxycycline	Capsule	100 mg/1	Oral	REMEDYREPACK INC.	2022-08-22	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Greenstone LLC	2015-05-01	Not applicable
Doxycycline	Injection, powder, lyophilized, for solution	100 mg/10mL	Intravenous	General Injectables & Vaccines	2010-08-01	2017-01-18
Doxycycline	Tablet, coated	100 mg/1	Oral	Blenheim Pharmacal, Inc.	2012-05-09	Not applicable
Doxycycline	Tablet, film coated	75 mg/1	Oral	Zydus Pharmaceuticals USA Inc.	2018-01-11	Not applicable
Doxycycline	Tablet	50 mg/1	Oral	Lake Erie Medical DBA Quality Care Products LLC	2012-01-05	Not applicable
Doxycycline	Injection, powder, lyophilized, for solution	100 mg/10mL	Intravenous	Zydus Lifesciences Limited	2018-02-01	Not applicable
Doxycycline	Tablet, film coated	150 mg/1	Oral	Lannett Company, Inc.	2008-08-25	Not applicable
Doxycycline	Capsule	75 mg/1	Oral	Lupin Pharmaceuticals,Inc.	2015-07-08	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	A-S Medication Solutions	2015-05-28	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	AvPAK	2020-05-15	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Cosette Pharmaceuticals, Inc.	2015-05-28	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Mayne Pharma Inc.	2018-03-09	2019-11-30
Doxycycline	Capsule	100 mg/1	Oral	A-S Medication Solutions	2022-08-01	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Novel Laboratories, Inc.	2015-05-28	Not applicable
Doxycycline	Capsule	50 mg/1	Oral	Eon Labs, Inc.	2000-06-30	2012-03-31
Doxycycline	Capsule	100 mg/1	Oral	RedPharm Drug, Inc.	2018-01-01	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	REMEDYREPACK INC.	2023-05-04	Not applicable
Doxycycline	Tablet, coated	100 mg/1	Oral	Liberty Pharmaceuticals, Inc.	2003-07-02	Not applicable
Doxycycline	Tablet, coated	100 mg/1	Oral	Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC	2011-12-07	2014-12-31
Doxycycline	Tablet, film coated	100 mg/1	Oral	American Health Packaging	2017-11-01	Not applicable
Doxycycline	Capsule	50 mg/1	Oral	Lupin Pharmaceuticals, Inc.	2015-02-20	Not applicable
Doxycycline	Capsule	75 mg/1	Oral	Alembic Pharmaceuticals Limited	2017-07-31	Not applicable
Doxycycline	Tablet, film coated	50 mg/1	Oral	Lannett Company, Inc.	2005-12-08	Not applicable
Doxycycline	Capsule	75 mg/1	Oral	Zydus Pharmaceuticals USA Inc.	2016-03-14	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	American Health Packaging	2022-10-20	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	PD-Rx Pharmaceuticals, Inc.	2015-05-28	Not applicable
Doxycycline	Capsule	150 mg/1	Oral	Par Pharmaceutical, Inc.	2011-06-01	2024-02-28
Doxycycline	Tablet, film coated	150 mg/1	Oral	Zydus Lifesciences Limited	2018-01-11	Not applicable
Doxycycline	Tablet, coated	100 mg/1	Oral	Major Pharmaceuticals	2003-07-02	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Strides Pharma Science Limited	2022-08-01	Not applicable
Doxycycline	Tablet, film coated	100 mg/1	Oral	Denton Pharma, Inc. Dba Northwind Pharmaceuticals	2020-12-04	2024-12-31
Doxycycline	Capsule	100 mg/1	Oral	RedPharm Drug, Inc.	2016-03-14	Not applicable
Doxycycline	Injection, powder, lyophilized, for solution	100 mg/10mL	Intravenous	Gland Pharma Limited	2023-04-12	Not applicable
Doxycycline	Tablet, coated	100 mg/1	Oral	Hikma Pharmaceuticals USA Inc.	2003-07-02	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Proficient Rx LP	2021-11-19	Not applicable
Doxycycline	Capsule	75 mg/1	Oral	Zydus Lifesciences Limited	2016-03-14	Not applicable
Doxycycline	Tablet	75 mg/1	Oral	Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.	2012-05-01	Not applicable
Doxycycline	Tablet, coated	100 mg/1	Oral	A-S Medication Solutions	2003-07-02	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	RedPharm Drug, Inc.	2000-12-01	Not applicable
Doxycycline	Tablet, film coated	50 mg/1	Oral	Zydus Lifesciences Limited	2018-01-11	Not applicable
Doxycycline	Tablet, coated	100 mg/1	Oral	Denton Pharma, Inc. Dba Northwind Pharmaceuticals	2022-07-22	2024-08-31
Doxycycline	Capsule	100 mg/1	Oral	Proficient Rx LP	2016-04-29	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	REMEDYREPACK INC.	2017-01-31	2024-12-31
Doxycycline	Capsule	100 mg/1	Oral	Proficient Rx LP	2014-04-14	Not applicable
Doxycycline	Capsule	50 mg/1	Oral	Gw Pharmaceuticals Ltd.	2015-05-28	2019-09-30
Doxycycline	Capsule	100 mg/1	Oral	bryant ranch prepack	2000-12-26	Not applicable
Doxycycline	Tablet, film coated	150 mg/1	Oral	Mylan Pharmaceuticals Inc.	2007-06-08	2019-04-30
Doxycycline	Capsule	100 mg/1	Oral	PD-Rx Pharmaceuticals, Inc.	2015-05-28	Not applicable
Doxycycline	Capsule	75 mg/1	Oral	Cosette Pharmaceuticals, Inc.	2015-05-28	2022-10-31
Doxycycline	Tablet, film coated	75 mg/1	Oral	Sun Pharmaceutical Industries Limited	2018-08-06	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Cardinal Health	2000-12-01	2018-02-28
Doxycycline	Capsule	50 mg/1	Oral	Golden State Medical Supply, Inc.	2000-12-01	Not applicable
Doxycycline	Tablet, film coated	150 mg/1	Oral	Zydus Pharmaceuticals USA Inc.	2018-01-11	Not applicable
Doxycycline	Injection, powder, lyophilized, for solution	100 mg/10mL	Intravenous	Henry Schein, Inc	2022-01-10	Not applicable
Doxycycline	Powder, for suspension	25 mg/5mL	Oral	CIPLA USA, Inc	2008-07-16	2022-08-01
Doxycycline	Capsule	50 mg/1	Oral	bryant ranch prepack	2000-12-01	Not applicable
Doxycycline	Capsule	50 mg/1	Oral	H.J. Harkins Company, Inc.	2018-07-27	Not applicable
Doxycycline	Tablet	50 mg/1	Oral	Chartwell Rx, Llc	2012-05-01	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	American Health Packaging	2014-05-13	2024-05-31
Doxycycline	Capsule	100 mg/1	Oral	bryant ranch prepack	2015-05-28	2022-10-31
Doxycycline	Injection, powder, lyophilized, for solution	100 mg/10mL	Intravenous	Bedford Pharmaceuticals	2001-10-01	2011-09-30
Doxycycline	Capsule	50 mg/1	Oral	AvPAK	2020-05-15	Not applicable
Doxycycline	Capsule	75 mg/1	Oral	Cosette Pharmaceuticals, Inc.	2015-05-28	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	A-S Medication Solutions	2016-03-14	Not applicable
Doxycycline	Capsule	75 mg/1	Oral	Mayne Pharma Inc.	2018-03-09	2022-03-31
Doxycycline	Injection, powder, lyophilized, for solution	100 mg/10mL	Intravenous	Par Pharmaceutical, Inc.	2023-11-01	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	A-S Medication Solutions	2015-05-28	2019-06-30
Doxycycline	Capsule	100 mg/1	Oral	Remedy Repack	2016-08-22	2017-01-16
Doxycycline	Capsule	40 mg/1	Oral	Prasco Laboratories	2015-04-01	2025-05-31
Doxycycline	Tablet	75 mg/1	Oral	Strides Pharma Science Limited	2022-09-19	Not applicable
Doxycycline	Tablet, film coated	50 mg/1	Oral	Zydus Pharmaceuticals USA Inc.	2018-01-11	Not applicable
Doxycycline	Tablet, coated	100 mg/1	Oral	Oaklock, Llc	2020-03-19	Not applicable
Doxycycline	Tablet	100 mg/1	Oral	Lake Erie Medical DBA Quality Care Products LLC	2012-01-05	Not applicable
Doxycycline	Tablet, coated	100 mg/1	Oral	REMEDYREPACK INC.	2021-03-04	Not applicable
Doxycycline	Tablet, film coated	100 mg/1	Oral	Lannett Company, Inc.	2005-12-08	Not applicable
Doxycycline	Tablet	100 mg/1	Oral	A-S Medication Solutions	2012-05-01	Not applicable
Doxycycline	Capsule	50 mg/1	Oral	Lupin Pharmaceuticals,Inc.	2015-07-08	Not applicable
Doxycycline	Tablet, coated	100 mg/1	Oral	Acella Pharmaceuticals, LLC	2020-08-21	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Northwind Pharmaceuticals, LLC	2023-01-20	Not applicable
Doxycycline	Injection, powder, lyophilized, for solution	100 mg/10mL	Intravenous	General Injectables & Vaccines, Inc.	2019-12-20	2023-02-28
Doxycycline	Capsule	75 mg/1	Oral	Sun Pharmaceutical Industries, Inc.	2000-12-26	Not applicable
Doxycycline	Powder, for suspension	25 mg/5mL	Oral	Chartwell RX LLC	2008-07-16	Not applicable
Doxycycline	Tablet, film coated	100 mg/1	Oral	bryant ranch prepack	2005-12-08	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	PharmPak, Inc.	2019-07-12	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	bryant ranch prepack	2016-03-14	Not applicable
Doxycycline	Capsule	50 mg/1	Oral	Par Pharmaceutical, Inc.	2000-12-01	2024-11-30
Doxycycline	Tablet, coated	100 mg/1	Oral	Nucare Pharmaceuticals,inc.	2003-07-02	2019-12-31
Doxycycline	Capsule	100 mg/1	Oral	REMEDYREPACK INC.	2017-02-14	2019-10-01
Doxycycline	Tablet	50 mg/1	Oral	Par Pharmaceutical, Inc.	2000-12-15	2020-03-31
Doxycycline	Capsule	100 mg/1	Oral	REMEDYREPACK INC.	2017-02-10	Not applicable
Doxycycline	Injection, powder, for solution	100 mg/1	Intravenous	Hikma Pharmaceuticals USA Inc.	2021-05-17	Not applicable
Doxycycline	Capsule	150 mg/1	Oral	Par Pharmaceutical Inc.	2011-06-01	2011-06-07
Doxycycline	Capsule	50 mg/1	Oral	Zydus Pharmaceuticals USA Inc.	2016-03-14	Not applicable
Doxycycline	Tablet	150 mg/1	Oral	Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.	2012-05-01	Not applicable
Doxycycline	Tablet, film coated	100 mg/1	Oral	RedPharm Drug, Inc.	2020-01-01	Not applicable
Doxycycline	Injection, powder, lyophilized, for solution	100 mg/10mL	Intravenous	Zydus Pharmaceuticals USA Inc.	2018-02-01	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Preferred Pharmaceuticals Inc.	2024-02-20	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Lake Erie Medical DBA Quality Care Products LLC	2000-12-01	2019-10-11
Doxycycline	Tablet, film coated	75 mg/1	Oral	Eon Labs, Inc.	2006-11-27	2014-06-01
Doxycycline	Capsule	100 mg/1	Oral	Nucare Pharmaceuticals,inc.	2021-11-19	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	PD-Rx Pharmaceuticals, Inc.	2015-05-28	2019-09-30
Doxycycline	Capsule	100 mg/1	Oral	Lupin Pharmaceuticals, Inc.	2015-02-20	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	REMEDYREPACK INC.	2016-07-20	2017-08-25
Doxycycline	Tablet	100 mg/1	Oral	Par Pharmaceutical, Inc.	2000-12-15	2020-08-31
Doxycycline	Tablet, film coated	150 mg/1	Oral	Sun Pharmaceutical Industries Limited	2018-08-06	Not applicable
Doxycycline	Tablet, coated	100 mg/1	Oral	QPharma Inc	2003-07-02	Not applicable
Doxycycline	Capsule	50 mg/1	Oral	Zydus Lifesciences Limited	2016-03-14	Not applicable
Doxycycline	Tablet	50 mg/1	Oral	Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.	2012-05-01	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	PD-Rx Pharmaceuticals, Inc.	2015-05-28	Not applicable
Doxycycline	Capsule	75 mg/1	Oral	Novel Laboratories, Inc.	2015-05-28	Not applicable
Doxycycline	Tablet, film coated	100 mg/1	Oral	AvKARE	2019-02-15	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Proficient Rx LP	2015-05-28	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Proficient Rx LP	2022-08-01	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	St. Mary's Medical Park Pharmacy	2018-02-15	2019-09-30
Doxycycline	For suspension	25 mg/5mL	Oral	Lupin Pharmaceuticals, Inc.	2013-06-11	Not applicable
Doxycycline	Tablet, film coated	100 mg/1	Oral	Quality Care Products, LLC	2023-06-16	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	PD-Rx Pharmaceuticals, Inc.	2015-07-08	2018-08-29
Doxycycline	Capsule	150 mg/1	Oral	Strides Pharma Science Limited	2022-08-01	Not applicable
Doxycycline	Capsule	50 mg/1	Oral	bryant ranch prepack	2000-12-01	2024-11-30
Doxycycline	Capsule	100 mg/1	Oral	Proficient Rx LP	2000-12-01	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	A-S Medication Solutions	2015-05-28	2019-07-31
Doxycycline	Tablet	100 mg/1	Oral	Direct Rx	2015-01-01	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Asclemed Usa, Inc.	2021-11-19	Not applicable
Doxycycline	Tablet	50 mg/1	Oral	Strides Pharma Science Limited	2022-09-19	Not applicable
Doxycycline	Tablet, coated	100 mg/1	Oral	Remedy Repack	2013-05-24	2017-01-16
Doxycycline	Tablet, film coated	100 mg/1	Oral	Zydus Lifesciences Limited	2018-01-11	Not applicable
Doxycycline	Capsule	40 mg/1	Oral	Mayne Pharma Inc.	2023-02-27	Not applicable
Doxycycline	Tablet, coated	100 mg/1	Oral	Legacy Pharmaceutical Packaging	2010-05-01	Not applicable
Doxycycline	Tablet, film coated	50 mg/1	Oral	Directrx	2015-01-01	Not applicable
Doxycycline	Capsule	150 mg/1	Oral	Amneal Pharmaceuticals of New York Llc	2011-02-17	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	REMEDYREPACK INC.	2023-12-26	Not applicable
Doxycycline	Tablet	100 mg/1	Oral	REMEDYREPACK INC.	2016-12-05	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Rpk Pharmaceuticals, Inc.	2000-12-26	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	A-S Medication Solutions	2000-12-01	2024-12-31
Doxycycline	Capsule	100 mg/1	Oral	St. Mary's Medical Park Pharmacy	2021-11-19	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Gw Pharmaceuticals Ltd.	2015-05-28	2019-09-30
Doxycycline	Capsule	100 mg/1	Oral	bryant ranch prepack	2015-02-20	Not applicable
Doxycycline	Injection, powder, lyophilized, for solution	100 mg/10mL	Intravenous	Northstar Rx Llc.	2022-08-01	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	RedPharm Drug, Inc.	2014-04-14	Not applicable
Doxycycline	Tablet	100 mg/1	Oral	Strides Pharma Science Limited	2022-09-19	Not applicable
Doxycycline	Tablet, coated	100 mg/1	Oral	St Marys Medical Park Pharmacy	2003-07-02	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Aphena Pharma Solutions - Tennessee, LLC	2015-05-28	2019-09-30
Doxycycline	Capsule	100 mg/1	Oral	Denton Pharma, Inc. Dba Northwind Pharmaceuticals	2022-07-21	2024-07-31
Doxycycline	Tablet, coated	100 mg/1	Oral	Directrx	2015-12-17	Not applicable
Doxycycline	Tablet, coated	100 mg/1	Oral	REMEDYREPACK INC.	2022-02-10	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Quality Care Products, LLC	2019-02-08	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Alembic Pharmaceuticals Inc.	2017-07-31	Not applicable
Doxycycline	Injection, powder, lyophilized, for solution	100 mg/10mL	Intravenous	Piramal Critical Care Inc	2023-06-05	Not applicable
Doxycycline	Injection, powder, lyophilized, for solution	100 mg/10mL	Intravenous	Pfizer Laboratories Div Pfizer Inc.	2012-08-21	2017-12-31
Doxycycline	Capsule	50 mg/1	Oral	PD-Rx Pharmaceuticals, Inc.	2015-07-08	2018-08-29
Doxycycline	Capsule	100 mg/1	Oral	PD-Rx Pharmaceuticals, Inc.	2015-05-28	Not applicable
Doxycycline	Tablet	150 mg/1	Oral	Par Pharmaceutical, Inc.	2000-12-15	2020-06-30
Doxycycline	Tablet, coated	100 mg/1	Oral	Cardinal Health 107, LLC	2013-03-22	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Direct_Rx	2019-06-25	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Lupin Pharmaceuticals,Inc.	2015-07-08	Not applicable
Doxycycline	Capsule	50 mg/1	Oral	bryant ranch prepack	2015-05-28	Not applicable
Doxycycline	Tablet, film coated	100 mg/1	Oral	Mylan Pharmaceuticals Inc.	2006-11-17	2019-04-30
Doxycycline	Capsule	100 mg/1	Oral	RedPharm Drug	2022-08-01	Not applicable
Doxycycline	Tablet, film coated	100 mg/1	Oral	Zydus Pharmaceuticals USA Inc.	2018-01-11	Not applicable
Doxycycline	Capsule	40 mg/1	Oral	Dr.Reddys Laboratories Inc	2024-04-23	Not applicable
Doxycycline	Injection, powder, lyophilized, for solution	100 mg/10mL	Intravenous	Fosun Pharma USA Inc	2023-04-12	Not applicable
Doxycycline	Tablet, film coated	100 mg/1	Oral	A-S Medication Solutions	2005-12-08	Not applicable
Doxycycline	Tablet, coated	100 mg/1	Oral	Cardinal Health	2004-08-03	2014-09-30
Doxycycline	Capsule	100 mg/1	Oral	RedPharm Drug, Inc.	2015-05-28	2022-10-31
Doxycycline	Capsule	100 mg/1	Oral	Nucare Pharmaceuticals,inc.	2021-11-19	Not applicable
Doxycycline	Capsule	75 mg/1	Oral	Lupin Pharmaceuticals, Inc.	2015-02-20	2016-09-30
Doxycycline	Tablet	100 mg/1	Oral	Northwind Pharmaceuticals, LLC	2022-11-29	Not applicable
Doxycycline	Tablet, coated	100 mg/1	Oral	PD-Rx Pharmaceuticals, Inc.	2003-07-02	Not applicable
Doxycycline	Tablet, coated	100 mg/1	Oral	Rebel Distributors	2003-07-02	Not applicable
Doxycycline	Capsule	100 mg/1	Oral	Rpk Pharmaceuticals, Inc.	2015-05-28	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Chartwell RX LLC	1984-09-11	2014-06-10
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Amneal Pharmaceuticals NY LLC	2022-11-09	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Alembic Pharmaceuticals Inc.	2020-05-15	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	bryant ranch prepack	1984-09-11	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	A S Medication Solutions	1986-07-10	Not applicable
Doxycycline Hyclate	Tablet, delayed release	150 mg/1	Oral	Alembic Pharmaceuticals Limited	2022-01-04	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Denton Pharma, Inc. Dba Northwind Pharmaceuticals	2017-11-21	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Dispensing Solutions, Inc.	1986-07-10	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Rpk Pharmaceuticals, Inc.	1984-09-11	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Department Of State Health Services, Pharmacy Branch	1986-07-10	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	AvKARE	2019-07-22	Not applicable
Doxycycline Hyclate	Capsule, gelatin coated	100 mg/1	Oral	PD-Rx Pharmaceuticals, Inc.	1984-05-07	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	REMEDYREPACK INC.	2016-11-15	2018-06-13
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Life Line Home Care Services	2012-02-08	Not applicable
Doxycycline Hyclate	Capsule, gelatin coated	100 mg/1	Oral	Proficient Rx LP	1984-05-07	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Bi-Coastal Pharma International, LLC	2020-05-28	Not applicable
Doxycycline Hyclate	Tablet, delayed release	75 mg/1	Oral	Impax Generics	2011-04-11	2016-11-14
Doxycycline Hyclate	Capsule, gelatin coated	100 mg/1	Oral	PD-Rx Pharmaceuticals, Inc.	1984-05-07	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	A-S Medication Solutions	1984-09-11	Not applicable
Doxycycline Hyclate	Tablet, film coated	20 mg/1	Oral	Sun Pharmaceutical Industries, Inc.	2005-05-13	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Nostrum Laboratories, Inc.	2020-12-21	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	PD-Rx Pharmaceuticals, Inc.	1986-07-10	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	REMEDYREPACK INC.	2021-06-25	Not applicable
Doxycycline Hyclate	Tablet, coated	75 mg/1	Oral	Epic Pharma, LLC	2020-12-16	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	bryant ranch prepack	1990-01-01	2018-09-30
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Alembic Pharmaceuticals Limited	2018-06-18	Not applicable
Doxycycline Hyclate	Tablet, delayed release	200 mg/1	Oral	Alembic Pharmaceuticals Inc.	2022-01-04	Not applicable
Doxycycline Hyclate	Tablet, film coated	20 mg/1	Oral	Alembic Pharmaceuticals Limited	2020-03-05	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	REMEDYREPACK INC.	2023-04-10	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Aidarex Pharmaceuticals LLC	1984-05-07	Not applicable
Doxycycline Hyclate	Capsule, gelatin coated	100 mg/1	Oral	Unit Dose Services	1984-05-07	2016-09-03
Doxycycline Hyclate	Capsule	50 mg/1	Oral	PD-Rx Pharmaceuticals, Inc.	2016-06-27	2021-05-01
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Nucare Pharmaceuticals,inc.	1990-09-01	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Ajanta Pharma USA Inc.	2018-09-24	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Amneal Pharmaceuticals NY LLC	2016-06-28	Not applicable
Doxycycline Hyclate	Tablet, delayed release	75 mg/1	Oral	Zydus Lifesciences Limited	2018-12-21	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Chartwell Governmental & Specialty RX, LLC	1984-09-11	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Advanced Rx Pharmacy of Tennessee, LLC	2023-03-02	Not applicable
Doxycycline Hyclate	Tablet	100 mg/1	Oral	Aphena Pharma Solutions - Tennessee, LLC	2013-11-25	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	IVAX Pharmaceuticals, Inc.	2010-03-24	2011-02-28
Doxycycline Hyclate	Tablet	100 mg/1	Oral	Physicians Total Care, Inc.	1994-03-24	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Denton Pharma, Inc. Dba Northwind Pharmaceuticals	2018-03-05	Not applicable
Doxycycline Hyclate	Tablet	100 mg/1	Oral	A-S Medication Solutions	2019-10-09	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	A-S Medication Solutions	1984-09-11	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	A-S Medication Solutions	1984-09-11	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	AvPAK	2014-06-04	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Direct Rx	2020-12-01	Not applicable
Doxycycline Hyclate	Tablet, delayed release	100 mg/1	Oral	Actavis Pharma, Inc.	2013-10-28	2015-07-31
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	bryant ranch prepack	1984-09-11	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	A-S Medication Solutions	2016-10-01	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Preferred Pharmaceuticals Inc.	2016-08-22	Not applicable
Doxycycline Hyclate	Capsule, gelatin coated	100 mg/1	Oral	Nucare Pharmaceuticals, Inc.	1984-05-07	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Proficient Rx LP	1984-09-11	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Sun Pharmaceutical Industries, Inc.	1986-07-10	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Remedy Repack	2012-03-29	2016-10-07
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Alvogen, Inc.	2016-06-27	2021-05-01
Doxycycline Hyclate	Tablet, delayed release	75 mg/1	Oral	Alembic Pharmaceuticals Inc.	2022-01-04	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Alembic Pharmaceuticals Inc.	2018-06-18	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Mylan Pharmaceuticals Inc.	1983-02-15	Not applicable
Doxycycline Hyclate	Tablet, film coated	20 mg/1	Oral	Sandoz	2005-12-12	2012-04-30
Doxycycline Hyclate	Capsule	100 mg/1	Oral	H.J. Harkins Company	1984-11-07	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Quality Care Products, LLC	2012-04-16	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	A-S Medication Solutions	1986-07-10	2019-01-31
Doxycycline Hyclate	Capsule	50 mg/1	Oral	IVAX Pharmaceuticals, Inc.	2010-03-24	2011-02-28
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Hikma Pharmaceuticals USA Inc.	1984-05-07	Not applicable
Doxycycline Hyclate	Tablet, film coated	20 mg/1	Oral	Burke Therapeutics, LLC	2014-09-29	2016-10-03
Doxycycline hyclate	Capsule	100 mg/1	Oral	bryant ranch prepack	2022-01-10	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Nucare Pharmaceuticals,inc.	2016-06-28	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Hikma Pharmaceuticals USA Inc.	1984-05-07	Not applicable
Doxycycline Hyclate	Capsule, gelatin coated	100 mg/1	Oral	Apace Packaging	1984-05-07	2015-05-31
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Clinical Solutions Wholesale, LLC	1984-09-11	2018-10-30
Doxycycline Hyclate	Capsule	100 mg/1	Oral	TYA Pharmaceuticals	1977-02-14	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Proficient Rx LP	1984-09-11	Not applicable
Doxycycline hyclate	Capsule	100 mg/1	Oral	Nucare Pharmaceuticals,inc.	2022-01-10	Not applicable
Doxycycline Hyclate	Tablet, delayed release	50 mg/1	Oral	Solco Healthcare US LLC	2018-11-28	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Blenheim Pharmacal, Inc.	2013-01-14	Not applicable
Doxycycline Hyclate	Capsule, gelatin coated	50 mg/1	Oral	PD-Rx Pharmaceuticals, Inc.	1984-11-07	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	A-S Medication Solutions	1984-05-07	Not applicable
Doxycycline Hyclate	Tablet, delayed release	100 mg/1	Oral	Mylan Pharmaceuticals Inc.	2010-12-30	2019-08-31
Doxycycline Hyclate	Capsule	100 mg/1	Oral	RedPharm Drug, Inc.	1984-05-07	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Actavis Pharma, Inc.	1990-01-01	2020-04-30
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Nucare Pharmaceuticals,inc.	1986-07-10	Not applicable
Doxycycline Hyclate	Tablet	100 mg/1	Oral	Zydus Pharmaceuticals USA Inc.	2018-12-21	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	MHC Pharma, LLC	1984-09-11	2019-05-31
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	RedPharm Drug, Inc.	1986-07-10	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Nucare Pharmaceuticals, Inc.	1984-09-11	Not applicable
Doxycycline Hyclate	Tablet, delayed release	80 mg/1	Oral	Basiem	2019-04-04	2019-04-26
Doxycycline Hyclate	Capsule, gelatin coated	100 mg/1	Oral	Hikma Pharmaceuticals USA Inc.	1984-05-07	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Chartwell RX LLC	1984-09-11	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Northwind Pharmaceuticals, LLC	2023-01-05	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	HHS/Program Support Center/Supply Service Center	2011-06-17	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	State of Florida DOH Central Pharmacy	2009-07-01	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Safecor Health, LLC	1986-07-10	2018-10-18
Doxycycline Hyclate	Tablet, coated	100 mg/1	Oral	Bi-Coastal Pharma International, LLC	2020-05-28	Not applicable
Doxycycline Hyclate	Tablet	100 mg/1	Oral	McKesson Corporation dba SKY Packaging	1990-01-01	Not applicable
Doxycycline Hyclate	Tablet, film coated	150 mg/1	Oral	Mayne Pharma Commercial LLC	2017-06-14	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Rpk Pharmaceuticals, Inc.	2016-10-01	Not applicable
Doxycycline Hyclate	Tablet	100 mg/1	Oral	Preferred Pharmaceuticals, Inc.	2013-12-17	2019-08-30
Doxycycline Hyclate	Capsule	100 mg/1	Oral	PD-Rx Pharmaceuticals, Inc.	1986-07-10	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	State of Florida DOH Central Pharmacy	2013-01-01	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	REMEDYREPACK INC.	2018-12-14	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Denton Pharma, Inc. Dba Northwind Pharmaceuticals	2022-02-09	2024-06-30
Doxycycline Hyclate	Tablet, coated	75 mg/1	Oral	Lupin Pharmaceuticals, Inc.	2017-10-30	Not applicable
Doxycycline Hyclate	Capsule, gelatin coated	100 mg/1	Oral	Versa Pharm Incorporated	1998-04-01	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	REMEDYREPACK INC.	2021-09-08	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Par Pharmaceutical	1984-09-11	2018-09-30
Doxycycline Hyclate	Capsule	100 mg/1	Oral	RedPharm Drug, Inc.	1984-09-11	2021-10-31
Doxycycline Hyclate	Capsule	100 mg/1	Oral	PD-Rx Pharmaceuticals, Inc.	2019-06-07	Not applicable
Doxycycline Hyclate	Tablet	50 mg/1	Oral	PuraCap Laboratories LLC dba Blu Pharmaceuticals	2021-11-19	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Proficient Rx LP	1984-09-11	Not applicable
Doxycycline Hyclate	Tablet, delayed release	50 mg/1	Oral	Mayne Pharma Commercial LLC	2016-05-26	2024-07-31
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Cipla USA, Inc.	1984-09-11	2019-07-31
Doxycycline Hyclate	Capsule	100 mg/1	Oral	A-S Medication Solutions	2016-06-28	Not applicable
Doxycycline Hyclate	Tablet, delayed release	200 mg/1	Oral	Solbuiomix	2017-06-20	2017-07-12
Doxycycline Hyclate	Capsule	100 mg/1	Oral	PD-Rx Pharmaceuticals, Inc.	1984-05-07	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Blenheim Pharmacal, Inc.	2009-12-22	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Av Kare, Inc.	2013-06-06	2017-02-06
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Nucare Pharmaceuticals,inc.	1984-09-11	Not applicable
Doxycycline Hyclate	Tablet	100 mg/1	Oral	A S Medication Solutions	1983-02-02	Not applicable
Doxycycline Hyclate	Tablet, film coated	20 mg/1	Oral	bryant ranch prepack	2005-05-13	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	A-S Medication Solutions	2016-06-27	2019-02-28
Doxycycline Hyclate	Tablet	100 mg/1	Oral	Proficient Rx LP	2019-10-09	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Nucare Pharmaceuticals,inc.	2016-06-28	Not applicable
Doxycycline Hyclate	Tablet, film coated	150 mg/1	Oral	Alembic Pharmaceuticals Inc.	2020-06-30	Not applicable
Doxycycline hyclate	Tablet	100 mg/1	Oral	Zydus Pharmaceuticals (USA) Inc.	2018-04-02	2019-04-26
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Harris Pharmaceutical, Inc	1984-09-11	2021-10-31
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Denton Pharma, Inc. Dba Northwind Pharmaceuticals	2022-07-06	2025-10-31
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Quality Care Products, LLC	2019-03-18	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Citron Pharma LLC	1984-09-11	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Mylan Pharmaceuticals Inc.	1982-03-29	2018-09-30
Doxycycline Hyclate	Capsule	100 mg/1	Oral	A-S Medication Solutions	1984-09-11	Not applicable
Doxycycline Hyclate	Tablet	100 mg/1	Oral	Lupin Pharmaceuticals,Inc.	2017-09-06	Not applicable
Doxycycline Hyclate	Tablet, delayed release	150 mg/1	Oral	Zydus Lifesciences Limited	2018-12-21	Not applicable
Doxycycline Hyclate	Tablet, film coated	20 mg/1	Oral	PD-Rx Pharmaceuticals, Inc.	2005-05-13	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Chartwell RX LLC	1984-09-11	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Stat Rx USA	1984-05-07	Not applicable
Doxycycline Hyclate	Tablet, delayed release	200 mg/1	Oral	Mayne Pharma Commercial LLC	2016-02-01	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Proficient Rx LP	1984-09-11	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	bryant ranch prepack	1984-09-11	Not applicable
Doxycycline Hyclate	Tablet	100 mg/1	Oral	bryant ranch prepack	2019-10-09	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	PD-Rx Pharmaceuticals, Inc.	1984-09-11	2019-08-13
Doxycycline Hyclate	Tablet, coated	150 mg/1	Oral	Apotex Corp.	2019-08-01	2025-12-31
Doxycycline Hyclate	Capsule	100 mg/1	Oral	American Health Packaging	2020-04-17	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	MHC Pharma, LLC	1984-09-11	2017-12-31
Doxycycline Hyclate	Capsule, gelatin coated	100 mg/1	Oral	Clinical Solutions Wholsesale	1984-05-07	2017-06-23
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Chartwell Governmental & Specialty RX, LLC	1984-09-11	Not applicable
Doxycycline Hyclate	Tablet, delayed release	200 mg/1	Oral	Solco Healthcare US LLC	2016-11-28	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	IVAX Pharmaceuticals, Inc.	1984-09-11	2014-07-31
Doxycycline hyclate	Capsule	50 mg/1	Oral	Viona Pharmaceuticals Inc	2022-01-10	Not applicable
Doxycycline Hyclate	Tablet, film coated	50 mg/1	Oral	Chartwell Governmental & Specialty RX, LLC	2021-07-21	Not applicable
Doxycycline Hyclate	Tablet	20 mg/1	Oral	bryant ranch prepack	2019-08-30	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	A-S Medication Solutions LLC	1986-07-10	2015-02-15
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Advanced Rx Pharmacy of Tennessee, LLC	2022-11-04	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Aphena Pharma Solutions Tennessee, Inc.	1986-07-10	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Direct_Rx	2019-09-10	Not applicable
Doxycycline Hyclate	Tablet	100 mg/1	Oral	C.O. Truxton, Inc.	2013-11-25	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Ajanta Pharma USA Inc.	2018-09-24	Not applicable
Doxycycline Hyclate	Tablet, delayed release	150 mg/1	Oral	Mylan Pharmaceuticals Inc.	2012-04-30	2019-08-31
Doxycycline Hyclate	Capsule, gelatin coated	50 mg/1	Oral	bryant ranch prepack	1984-11-07	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	bryant ranch prepack	1984-09-11	Not applicable
Doxycycline Hyclate	Tablet, film coated	20 mg/1	Oral	Chartwell Rx, Llc	2005-11-10	Not applicable
Doxycycline Hyclate	Tablet	20 mg/1	Oral	Larken Laboratories, Inc.	2010-11-15	Not applicable
Doxycycline Hyclate	Tablet, delayed release	75 mg/1	Oral	Mayne Pharma Commercial LLC	2013-07-08	2024-07-31
Doxycycline Hyclate	Capsule	100 mg/1	Oral	A-S Medication Solutions	1984-09-11	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	A-S Medication Solutions	1984-09-11	Not applicable
Doxycycline Hyclate	Capsule, gelatin coated	100 mg/1	Oral	bryant ranch prepack	1984-05-07	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	A-S Medication Solutions	1986-07-10	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Nucare Pharmaceuticals, Inc.	1984-09-11	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Nucare Pharmaceuticals, Inc.	1984-09-11	2019-12-31
Doxycycline Hyclate	Tablet	100 mg/1	Oral	Changzhou Pharmaceutical Factory	2020-01-01	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Goldline Laboratories, Inc.	1984-09-11	2011-04-30
Doxycycline Hyclate	Tablet, delayed release	100 mg/1	Oral	Alembic Pharmaceuticals Limited	2022-01-04	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Nucare Pharmaceuticals,inc.	2016-10-01	Not applicable
Doxycycline Hyclate	Tablet, film coated	50 mg/1	Oral	Alembic Pharmaceuticals Inc.	2021-09-15	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Preferred Pharmaceuticals Inc.	2020-03-10	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Actavis Pharma, Inc.	1990-01-01	2020-07-31
Doxycycline Hyclate	Capsule	100 mg/1	Oral	PD-Rx Pharmaceuticals, Inc.	1986-07-10	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Chartwell RX LLC	1984-09-11	2014-06-10
Doxycycline Hyclate	Capsule, gelatin coated	100 mg/1	Oral	Carilion Materials Management	1984-05-07	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	A-S Medication Solutions	1986-07-10	2017-10-31
Doxycycline Hyclate	Tablet, delayed release	75 mg/100mg	Oral	Mayne Pharma International Pty Ltd	2013-07-08	2013-07-17
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Nucare Pharmaceuticals,inc.	1990-09-01	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Proficient Rx LP	1986-07-10	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Proficient Rx LP	2016-06-28	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Epic Pharma, LLC	2016-10-01	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	A-S Medication Solutions	1984-09-11	Not applicable
Doxycycline Hyclate	Tablet, delayed release	150 mg/1	Oral	Sonoma Pharmaceuticals, Inc.	2016-11-28	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Denton Pharma, Inc. Dba Northwind Pharmaceuticals	2020-02-24	2024-02-29
Doxycycline Hyclate	Tablet	100 mg/1	Oral	REMEDYREPACK INC.	2023-09-24	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	RedPharm Drug, Inc.	1984-09-11	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Apothecary Shop Wholesale Inc.	2011-07-01	Not applicable
Doxycycline hyclate	Capsule	100 mg/1	Oral	Zydus Lifesciences Limited	2018-09-12	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Proficient Rx LP	1984-09-11	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Aidarex Pharmaceuticals LLC	1982-10-13	Not applicable
Doxycycline Hyclate	Tablet, film coated	20 mg/1	Oral	Core Pharma, Llc	2005-12-12	2016-03-11
Doxycycline Hyclate	Capsule, gelatin coated	100 mg/1	Oral	REMEDYREPACK INC.	2017-03-09	2020-04-01
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Remedy Repack	2012-07-16	2013-07-16
Doxycycline Hyclate	Capsule	100 mg/1	Oral	bryant ranch prepack	1984-09-11	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Blenheim Pharmacal, Inc.	2011-11-15	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Alvogen, Inc.	2016-07-19	2023-05-01
Doxycycline Hyclate	Tablet, delayed release	150 mg/1	Oral	Alembic Pharmaceuticals Inc.	2022-01-04	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Zhejiang Yongtai Pharmaceutical Co., Ltd	2021-09-08	Not applicable
Doxycycline Hyclate	Tablet, film coated	20 mg/1	Oral	Alembic Pharmaceuticals Inc.	2020-03-05	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Unit Dose Services	2016-06-28	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Av Kare, Inc.	2013-07-23	2017-02-06
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Preferred Pharmaceuticals Inc.	2015-08-19	2019-08-30
Doxycycline Hyclate	Capsule	100 mg/1	Oral	PD-Rx Pharmaceuticals, Inc.	1986-07-10	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	REMEDYREPACK INC.	2018-08-16	Not applicable
Doxycycline Hyclate	Tablet	100 mg/1	Oral	Tris Pharma Inc	2019-10-09	Not applicable
Doxycycline Hyclate	Tablet, film coated	75 mg/1	Oral	Mayne Pharma Commercial LLC	2017-06-14	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Nucare Pharmaceuticals, Inc.	1984-09-11	Not applicable
Doxycycline Hyclate	Capsule, gelatin coated	100 mg/1	Oral	A-S Medication Solutions	1984-05-07	2017-02-28
Doxycycline Hyclate	Tablet, film coated	150 mg/1	Oral	Alembic Pharmaceuticals Limited	2020-06-30	Not applicable
Doxycycline Hyclate	Tablet	100 mg/1	Oral	Rpk Pharmaceuticals, Inc.	2019-10-09	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Physicians Total Care, Inc.	1993-06-11	Not applicable
Doxycycline hyclate	Capsule	100 mg/1	Oral	Nucare Pharmaceuticals,inc.	2022-01-10	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	AvPAK	2014-06-04	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	medsource pharmaceuticals	2020-07-01	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	bryant ranch prepack	1984-09-11	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Liberty Pharmaceuticals, Inc.	1984-05-07	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	A-S Medication Solutions	1986-07-10	Not applicable
Doxycycline Hyclate	Capsule, gelatin coated	100 mg/1	Oral	Nucare Pharmaceuticals, Inc.	1984-05-07	Not applicable
Doxycycline hyclate	Capsule	100 mg/1	Oral	Asclemed Usa, Inc.	2022-01-10	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Preferred Pharmaceuticals, Inc.	2015-04-21	2019-08-30
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Nucare Pharmaceuticals,inc.	1984-09-11	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Citron Pharma LLC	1984-09-11	Not applicable
Doxycycline Hyclate	Tablet	20 mg/1	Oral	Epic Pharma, LLC	2019-08-30	Not applicable
Doxycycline Hyclate	Tablet, delayed release	50 mg/1	Oral	Mylan Pharmaceuticals Inc.	2016-05-23	2022-02-28
Doxycycline Hyclate	Tablet	100 mg/1	Oral	RedPharm Drug	2019-10-09	Not applicable
Doxycycline Hyclate	Tablet, delayed release	75 mg/1	Oral	Actavis Pharma, Inc.	2013-11-01	2016-04-30
Doxycycline Hyclate	Tablet, film coated	20 mg/1	Oral	E5 Pharma, Llc.	2017-05-15	2017-05-15
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	REMEDYREPACK INC.	2019-12-11	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	A S Medication Solutions	1977-02-14	Not applicable
Doxycycline Hyclate	Capsule, gelatin coated	100 mg/1	Oral	Preferred Pharmaceuticals, Inc.	2011-06-09	Not applicable
Doxycycline Hyclate	Tablet, film coated	75 mg/1	Oral	Alembic Pharmaceuticals Inc.	2020-06-30	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Sun Pharmaceutical Industries, Inc.	1986-07-10	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Harris Pharmaceutical, Inc	1984-09-11	2021-06-30
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Pharmasource Meds, LLC	2023-01-13	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Remedy Repack	2013-02-12	2014-10-09
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	A-S Medication Solutions	1986-07-10	2017-06-30
Doxycycline hyclate	Capsule	100 mg/1	Oral	Zydus Pharmaceuticals (USA) Inc.	2018-09-12	Not applicable
Doxycycline Hyclate	Tablet, delayed release	75 mg/1	Oral	Mylan Pharmaceuticals Inc.	2010-12-30	2019-08-31
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	RedPharm Drug, Inc.	2016-10-01	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	PD-Rx Pharmaceuticals, Inc.	1986-07-10	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	HHS/Program Support Center/Supply Service Center	2011-06-17	Not applicable
Doxycycline Hyclate	Tablet	100 mg/1	Oral	Aphena Pharma Solutions (Formerly Test Pak)	2011-07-14	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Contract Pharmacy Services Pa	2010-03-10	Not applicable
Doxycycline hyclate	Tablet	150 mg/1	Oral	Ajanta Pharma USA Inc.	2020-06-01	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Golden State Medical Supply, Inc.	1984-09-11	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	A-S Medication Solutions	1984-09-11	Not applicable
Doxycycline Hyclate	Tablet	100 mg/1	Oral	Avera McKennan Hospital	2015-03-09	2017-05-24
Doxycycline Hyclate	Capsule	100 mg/1	Oral	A-S Medication Solutions	2016-06-28	Not applicable
Doxycycline Hyclate	Tablet	100 mg/1	Oral	bryant ranch prepack	2019-03-14	Not applicable
Doxycycline Hyclate	Tablet, delayed release	200 mg/1	Oral	Actavis Pharma, Inc.	2019-08-14	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	bryant ranch prepack	2016-06-28	Not applicable
Doxycycline Hyclate	Tablet	100 mg/1	Oral	A-S Medication Solutions	1984-09-11	2018-05-31
Doxycycline Hyclate	Tablet, delayed release	200 mg/1	Oral	Alembic Pharmaceuticals Limited	2022-01-04	Not applicable
Doxycycline Hyclate	Tablet	75 mg/1	Oral	Zydus Pharmaceuticals USA Inc.	2018-12-21	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Chartwell RX LLC	1984-09-11	2014-06-10
Doxycycline Hyclate	Tablet	100 mg/1	Oral	Nucare Pharmaceuticals,inc.	2019-10-09	Not applicable
Doxycycline hyclate	Capsule	50 mg/1	Oral	A-S Medication Solutions	2022-01-10	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	bryant ranch prepack	1986-07-10	Not applicable
Doxycycline Hyclate	Tablet	20 mg/1	Oral	STI Pharma LLC	2010-11-15	2018-12-31
Doxycycline Hyclate	Tablet	100 mg/1	Oral	Viona Pharmaceuticals Inc	2019-03-14	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Par Pharmaceutical	1984-09-11	2019-01-31
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Chartwell RX LLC	1984-09-11	Not applicable
Doxycycline Hyclate	Tablet, film coated	20 mg/1	Oral	Physicians Total Care, Inc.	2005-04-20	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	State of Florida DOH Central Pharmacy	2009-07-01	Not applicable
Doxycycline Hyclate	Tablet, delayed release	100 mg/1	Oral	Impax Generics	2011-04-11	2016-11-14
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Unit Dose Services	1984-09-11	Not applicable
Doxycycline Hyclate	Capsule, gelatin coated	50 mg/1	Oral	Major	1984-11-01	2016-02-28
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Lake Erie Medical DBA Quality Care Products LLC	1984-09-11	2019-10-11
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Aphena Pharma Solutions New Jersey, Llc	1986-07-10	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Major Pharmaceuticals	2008-08-05	Not applicable
Doxycycline Hyclate	Tablet, film coated	50 mg/1	Oral	Jg Pharma Inc.	2018-04-20	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Amneal Pharmaceuticals NY LLC	2016-06-28	Not applicable
Doxycycline Hyclate	Tablet, coated	150 mg/1	Oral	Epic Pharma, LLC	2020-12-16	Not applicable
Doxycycline Hyclate	Capsule, gelatin coated	100 mg/1	Oral	Northwind Pharmaceuticals	2017-03-14	Not applicable
Doxycycline Hyclate	Tablet	100 mg/1	Oral	Preferred Pharmaceuticals Inc	2022-09-08	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Alembic Pharmaceuticals Limited	2018-06-18	Not applicable
Doxycycline Hyclate	Tablet, delayed release	75 mg/1	Oral	Alembic Pharmaceuticals Limited	2022-01-04	Not applicable
Doxycycline Hyclate	Tablet	150 mg/1	Oral	Amneal Pharmaceuticals NY LLC	2017-10-09	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 1/1	Oral	Heritage Pharmaceuticals Inc.	2018-12-01	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	St. Mary's Medical Park Pharmacy	2020-02-19	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Nucare Pharmaceuticals, Inc.	1984-09-11	Not applicable
Doxycycline Hyclate	Tablet	100 mg/1	Oral	Preferred Pharmaceuticals Inc.	2023-06-23	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	A-S Medication Solutions	2016-10-01	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Remedy Repack	2012-08-24	2017-01-25
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Golden State Medical Supply, Inc.	2014-02-12	2017-01-02
Doxycycline Hyclate	Tablet	100 mg/1	Oral	Novel Laboratories, Inc.	2017-09-06	Not applicable
Doxycycline Hyclate	Tablet, delayed release	100 mg/1	Oral	Zydus Lifesciences Limited	2018-12-21	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Pharmasource Meds, LLC	2023-03-07	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	medsource pharmaceuticals	1986-07-10	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Stat Rx USA	1984-11-07	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Rebel Distributors	1984-11-07	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Changzhou Pharmaceutical Factory	2020-05-28	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Remedy Repack	2013-04-03	2014-04-04
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	A-S Medication Solutions	2016-07-19	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Proficient Rx LP	1984-09-11	Not applicable
Doxycycline Hyclate	Tablet, coated	75 mg/1	Oral	Apotex Corp.	2019-08-01	2025-12-31
Doxycycline Hyclate	Capsule	50 mg/1	Oral	bryant ranch prepack	1984-09-11	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	RedPharm Drug, Inc	2018-01-01	Not applicable
Doxycycline Hyclate	Tablet	100 mg/1	Oral	St. Mary's Medical Park Pharmacy	2019-10-09	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	MHC Pharma, LLC	1984-09-11	2018-01-31
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Remedy Repack	2012-01-12	2013-01-12
Doxycycline Hyclate	Tablet	100 mg/1	Oral	St. Mary's Medical Park Pharmacy	2022-08-09	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Alvogen, Inc.	2016-06-27	2021-10-01
Doxycycline Hyclate	Tablet, delayed release	100 mg/1	Oral	Alembic Pharmaceuticals Inc.	2022-01-04	Not applicable
Doxycycline Hyclate	Tablet, delayed release	150 mg/1	Oral	Mayne Pharma Commercial LLC	2013-07-08	2024-07-31
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Alembic Pharmaceuticals Inc.	2018-06-18	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Hikma Pharmaceutical	1990-09-01	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	bryant ranch prepack	1984-09-11	Not applicable
Doxycycline hyclate	Capsule	50 mg/1	Oral	bryant ranch prepack	2022-01-10	Not applicable
Doxycycline Hyclate	Tablet	100 mg/1	Oral	Cardinal Health	1983-02-02	2009-06-09
Doxycycline Hyclate	Capsule, gelatin coated	100 mg/1	Oral	A-S Medication Solutions	1984-05-07	2017-11-30
Doxycycline Hyclate	Capsule, gelatin coated	100 mg/1	Oral	bryant ranch prepack	1984-05-07	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Asclemed Usa, Inc.	1984-09-11	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Health Department, Oklahoma State	2023-02-01	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Legacy Pharmaceutical Packaging	2011-02-09	Not applicable
Doxycycline Hyclate	Tablet, delayed release	150 mg/1	Oral	Solco Healthcare US LLC	2016-11-28	Not applicable
Doxycycline Hyclate	Tablet	100 mg/1	Oral	Actavis Pharma, Inc.	1990-01-01	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Med Vantx, Inc.	1984-09-11	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	AvKARE	2019-07-22	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Cipla USA, Inc.	1984-09-11	2019-05-31
Doxycycline Hyclate	Tablet	100 mg/1	Oral	RedPharm Drug, Inc.	2019-03-14	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Sun Pharmaceutical Industries, Inc.	1986-07-10	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Apotheca, Inc.	1984-09-11	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Nucare Pharmaceuticals, Inc.	1984-09-11	2019-12-31
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Proficient Rx LP	1984-09-11	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	REMEDYREPACK INC.	2021-09-08	Not applicable
Doxycycline hyclate	Tablet	100 mg/1	Oral	Zydus Lifesciences Limited	2018-04-02	Not applicable
Doxycycline Hyclate	Capsule, gelatin coated	50 mg/1	Oral	Hikma Pharmaceuticals USA Inc.	1984-11-07	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Nostrum Laboratories, Inc.	2020-12-21	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	American Health Packaging	2015-06-29	2020-04-30
Doxycycline Hyclate	Tablet	150 mg/1	Oral	Zydus Pharmaceuticals USA Inc.	2018-12-21	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	PD-Rx Pharmaceuticals, Inc.	1984-09-11	2023-09-30
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Aphena Pharma Solutions - Tennessee, LLC	1984-09-11	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	ab2289a5-54dd-3b00-e053-2a95a90a0de4	2020-04-03	Not applicable
Doxycycline Hyclate	Tablet, coated	150 mg/1	Oral	Lupin Pharmaceuticals, Inc.	2017-10-30	Not applicable
Doxycycline Hyclate	Tablet, film coated	50 mg/1	Oral	Alembic Pharmaceuticals Limited	2021-09-15	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Contract Pharmacy Services Pa	2017-09-22	Not applicable
Doxycycline Hyclate	Tablet, delayed release	75 mg/100mg	Oral	Mayne Pharma International Pty Ltd	2013-07-08	2013-07-17
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Nucare Pharmaceuticals,inc.	1984-09-11	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Cipla USA, Inc.	1984-09-11	2019-06-30
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	A-S Medication Solutions	1984-09-11	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	bryant ranch prepack	2016-06-28	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Chartwell Governmental & Specialty RX, LLC	1984-09-11	Not applicable
Doxycycline Hyclate	Tablet	100 mg/1	Oral	Putney, Inc.	2015-02-20	2018-10-31
Doxycycline Hyclate	Tablet, film coated	20 mg/1	Oral	Lannett Company, Inc.	2005-11-10	2022-07-31
Doxycycline Hyclate	Tablet, delayed release	50 mg/1	Oral	Actavis Pharma, Inc.	2019-08-14	Not applicable
Doxycycline hyclate	Capsule	50 mg/1	Oral	Zydus Lifesciences Limited	2018-09-12	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	REMEDYREPACK INC.	2018-06-08	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	AvPAK	2014-06-04	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Advanced Rx Pharmacy of Tennessee, LLC	2016-06-28	Not applicable
Doxycycline Hyclate	Tablet	100 mg/1	Oral	Unit Dose Services	1990-01-01	2017-12-31
Doxycycline Hyclate	Tablet	100 mg/1	Oral	Pharmasource Meds, LLC	2023-04-10	Not applicable
Doxycycline Hyclate	Tablet, film coated	20 mg/1	Oral	Aidarex Pharmaceuticals LLC	2005-11-10	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Direct Rx	2019-11-12	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Cambridge Therapeutics Technologies, Llc	1984-09-11	Not applicable
Doxycycline Hyclate	Tablet, delayed release	80 mg/1	Oral	Mayne Pharma Commercial LLC	2020-10-02	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Lake Erie Medical DBA Quality Care Products LLC	2017-01-13	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Nucare Pharmaceuticals,inc.	1984-09-11	Not applicable
Doxycycline Hyclate	Tablet, film coated	75 mg/1	Oral	Alembic Pharmaceuticals Limited	2020-06-30	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Harris Pharmaceutical, Inc	1984-09-11	2023-09-30
Doxycycline Hyclate	Capsule, gelatin coated	100 mg/1	Oral	Golden State Medical Supply	1984-05-07	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	State of Florida DOH Central Pharmacy	2014-11-01	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Mylan Pharmaceuticals Inc.	1982-03-29	2018-09-30
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Zhejiang Yongtai Pharmaceutical Co., Ltd	2021-09-08	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	bryant ranch prepack	1984-09-11	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Av Kare, Inc.	2013-07-23	2017-02-06
Doxycycline Hyclate	Capsule	100 mg/1	Oral	REMEDYREPACK INC.	2018-11-03	2020-05-27
Doxycycline Hyclate	Tablet	100 mg/1	Oral	A S Medication Solutions	1983-02-02	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	bryant ranch prepack	2016-06-27	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Denton Pharma, Inc. Dba Northwind Pharmaceuticals	2021-01-19	2024-12-31
Doxycycline hyclate	Capsule	50 mg/1	Oral	Asclemed Usa, Inc.	2022-01-10	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	A-S Medication Solutions	1984-09-11	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Preferred Pharmaceuticals Inc.	2016-07-25	2019-08-30
Doxycycline Hyclate	Tablet	100 mg/1	Oral	Par Pharmaceutical	1984-09-11	2020-08-31
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Physicians Total Care, Inc.	1994-08-01	Not applicable
Doxycycline Hyclate	Capsule, gelatin coated	100 mg/1	Oral	bryant ranch prepack	1984-05-07	Not applicable
Doxycycline Hyclate	Capsule, gelatin coated	100 mg/1	Oral	PD-Rx Pharmaceuticals, Inc.	1984-05-07	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Preferred Pharmaceuticals Inc.	2020-02-28	Not applicable
Doxycycline Hyclate	Tablet, delayed release	200 mg/1	Oral	Mylan Pharmaceuticals Inc.	2016-05-19	2019-08-31
Doxycycline Hyclate	Capsule	100 mg/1	Oral	RedPharm Drug, Inc.	2019-07-22	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	A-S Medication Solutions	2016-06-27	2019-02-28
Doxycycline Hyclate	Capsule	100 mg/1	Oral	bryant ranch prepack	1984-05-07	Not applicable
Doxycycline Hyclate	Tablet	100 mg/1	Oral	REMEDYREPACK INC.	2023-03-30	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Rebel Distributors	1984-11-07	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Praxgen Pharmaceuticals LLC	2022-09-01	Not applicable
Doxycycline Hyclate	Tablet	100 mg/1	Oral	Liberty Pharmaceuticals, Inc.	1983-02-02	Not applicable
Doxycycline Hyclate	Tablet	75 mg/1	Oral	Amneal Pharmaceuticals NY LLC	2017-10-09	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Direct Rx	2014-01-01	Not applicable
Doxycycline Hyclate	Tablet	100 mg/1	Oral	A-S Medication Solutions	1990-01-01	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Alembic Pharmaceuticals Limited	2020-05-15	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	Citron Pharma LLC	1984-09-11	Not applicable
Doxycycline Hyclate	Tablet, film coated	50 mg/1	Oral	Chartwell RX LLC	2021-07-27	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Amerincan Health Packaging	2015-03-31	2016-10-25
Doxycycline Hyclate	Tablet, film coated	20 mg/1	Oral	IVAX Pharmaceuticals, Inc.	2005-05-17	2014-04-30
Doxycycline hyclate	Capsule	100 mg/1	Oral	Viona Pharmaceuticals Inc	2022-01-10	Not applicable
Doxycycline Hyclate	Capsule, gelatin coated	50 mg/1	Oral	A-S Medication Solutions	1984-11-07	Not applicable
Doxycycline Hyclate	Tablet, film coated	100 mg/1	Oral	A-S Medication Solutions	2016-07-19	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	C.O. Truxton, Inc.	2013-01-14	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	A-S Medication Solutions	1984-09-11	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Cardinal Health	1982-01-01	2011-03-31
Doxycycline Hyclate	Tablet	100 mg/1	Oral	Northwind Pharmaceuticals	2014-09-15	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Direct Rx	2017-11-01	Not applicable
Doxycycline hyclate	Capsule	50 mg/1	Oral	Zydus Pharmaceuticals (USA) Inc.	2018-09-12	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	RedPharm Drug, Inc.	2016-06-28	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	A-S Medication Solutions	1986-07-10	2018-08-31
Doxycycline Hyclate	Tablet	100 mg/1	Oral	PuraCap Laboratories LLC dba Blu Pharmaceuticals	2013-11-25	Not applicable
Doxycycline Hyclate	Tablet, coated	100 mg/1	Oral	HHS/Program Support Center/Supply Service Center	2003-07-02	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	State of Florida DOH Central Pharmacy	2009-07-01	Not applicable
Doxycycline hyclate	Tablet	75 mg/1	Oral	Ajanta Pharma USA Inc.	2020-06-01	Not applicable
Doxycycline Hyclate	Capsule	100 mg/1	Oral	Unit Dose Services	1984-09-11	Not applicable
Doxycycline Hyclate	Tablet, delayed release	100 mg/1	Oral	Mayne Pharma Commercial LLC	2013-07-08	2023-06-30
Doxycycline Hyclate	Capsule, gelatin coated	100 mg/1	Oral	bryant ranch prepack	1984-05-07	Not applicable
Doxycycline Hyclate	Capsule	50 mg/1	Oral	Hikma Pharmaceutical	1990-09-01	Not applicable
Doxycycline Hyclate Delayed Release	Tablet, delayed release	200 mg/1	Oral	Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.	2018-03-16	Not applicable
Doxycycline Hyclate Delayed Release	Tablet, delayed release	75 mg/1	Oral	Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.	2013-04-30	Not applicable
Doxycycline Hyclate Delayed Release	Tablet, delayed release	150 mg/1	Oral	Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.	2013-04-30	Not applicable
Doxycycline Hyclate Delayed Release	Tablet, delayed release	100 mg/1	Oral	Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.	2013-04-30	Not applicable
Doxycycline Monohydrate	Capsule	50 mg/1	Oral	PD-Rx Pharmaceuticals, Inc.	2005-02-07	2020-04-13
Doxycycline Monohydrate	Tablet	100 mg/1	Oral	Amerincan Health Packaging	2015-09-15	2018-08-31
Doxycycline Monohydrate	Capsule	75 mg/1	Oral	Actavis Pharma, Inc.	2011-02-07	2019-06-30
Doxycycline Monohydrate	Capsule	100 mg/1	Oral	PD-Rx Pharmaceuticals, Inc.	2005-02-07	2020-04-09
Doxycycline Monohydrate	Capsule	50 mg/1	Oral	Actavis Pharma, Inc.	2005-02-07	2020-01-31
Doxycycline Monohydrate	Tablet, film coated	100 mg/1	Oral	Advanced Rx Pharmacy of Tennessee, LLC	2023-04-11	Not applicable
Doxycycline Monohydrate	Capsule	100 mg/1	Oral	Rpk Pharmaceuticals, Inc.	2005-02-07	Not applicable
Doxycycline Monohydrate	Capsule	100 mg/1	Oral	Direct Rx	2019-04-05	Not applicable
Doxycycline Monohydrate	Capsule	100 mg/1	Oral	Direct_Rx	2022-05-26	Not applicable
Doxycycline Monohydrate	Capsule	100 mg/1	Oral	Physicians Total Care, Inc.	2010-10-22	Not applicable
Doxycycline Monohydrate	Capsule	100 mg/1	Oral	bryant ranch prepack	2005-02-07	2019-03-31
Doxycycline Monohydrate	Capsule	100 mg/1	Oral	Actavis Pharma, Inc.	2005-02-07	2020-01-31
Doxycycline Monohydrate	Capsule	100 mg/1	Oral	Aphena Pharma Solutions - Tennessee, LLC	2005-02-07	Not applicable
Jamp Doxycycline	Capsule	20 mg	Oral	Jamp Pharma Corporation	Not applicable	Not applicable
Jamp Doxycycline Capsules	Capsule	100 mg	Oral	Jamp Pharma Corporation	Not applicable	Not applicable
Mondoxyne	Capsule	50 mg/50mg	Oral	Oculus Innovative Scicences	2015-05-28	Not applicable
Mondoxyne	Capsule	75 mg/1	Oral	Sonoma Pharmaceuticals, Inc.	2015-05-28	2019-09-30
Mondoxyne NL	Capsule	75 mg/1	Oral	Sonoma Pharmaceuticals, Inc.	2015-05-28	Not applicable
Mondoxyne NL	Capsule	100 mg/1	Oral	Sonoma Pharmaceuticals, Inc.	2015-05-28	Not applicable
Mondoxyne NL 100mg	Capsule	100 mg/100mg	Oral	Oculus Innovative Scicences	2015-05-28	Not applicable
Monodox	Capsule	100 mg/1	Oral	Dierct Rx	2016-05-27	Not applicable
Morgidox	Capsule	100 mg/1	Oral	Medimetriks Pharmaceuticals, Inc.	2011-03-15	Not applicable
Morgidox	Capsule	100 mg/1	Oral	Medimetriks Pharmaceuticals, Inc.	2011-03-15	Not applicable
Morgidox	Capsule	50 mg/1	Oral; Topical	Medimetriks Pharmaceuticals, Inc.	1984-11-07	2019-11-01
Morgidox	Capsule	100 mg/1	Oral	Medimetriks Pharmaceuticals, Inc.	2011-03-15	Not applicable
Morgidox	Capsule	50 mg/1	Oral	Medimetriks Pharmaceuticals, Inc.	1984-11-07	2019-11-01
Morgidox	Capsule	100 mg/1	Oral	Medimetriks Pharmaceuticals, Inc.	2011-03-15	Not applicable
Ntp-doxycycline Capsules	Capsule	100 mg	Oral	TEVA Canada Limited	Not applicable	Not applicable
Ntp-doxycycline Tablets	Tablet	100 mg	Oral	TEVA Canada Limited	Not applicable	Not applicable
Nu-doxycycline Cap 100mg	Capsule	100 mg	Oral	Nu Pharm Inc	1993-12-31	2012-09-04
Nu-doxycycline Tab 100mg	Tablet	100 mg	Oral	Nu Pharm Inc	1993-12-31	2012-09-04
Ocudox	Capsule	50 mg/1	Oral	OCuSOFT Inc.	2011-04-01	2014-12-31
Okebo	Capsule	100 mg/1	Oral	Encore Dermatology Inc.	2017-11-20	Not applicable
Okebo	Capsule	75 mg/1	Oral	Encore Dermatology Inc.	2017-11-20	Not applicable
Oracea	Capsule, delayed release pellets	40 mg/1	Oral	Physicians Total Care, Inc.	2006-09-29	Not applicable
Penta-doxycycline Tablets	Tablet	100 mg / tab	Oral	Pentapharm Ltd.	Not applicable	Not applicable
PHL-doxycycline	Tablet	100 mg	Oral	Pharmel Inc	2007-07-27	2016-10-25
PHL-doxycycline	Capsule	100 mg	Oral	Pharmel Inc	2007-07-27	2016-10-25
PMS-doxycycline	Capsule	20 mg	Oral	Pharmascience Inc	Not applicable	Not applicable
PMS-doxycycline	Capsule	100 mg	Oral	Pharmascience Inc	2007-04-12	2019-07-04
PMS-doxycycline	Tablet	100 mg	Oral	Pharmascience Inc	2007-04-12	2019-07-04
Ratio-doxycycline	Capsule	100 mg	Oral	Ratiopharm Inc Division Of Teva Canada Limited	1994-12-31	2008-08-01
Ratio-doxycycline	Tablet	100 mg	Oral	Ratiopharm Inc Division Of Teva Canada Limited	1994-12-31	2008-08-01
Rho-doxycin - Cap 100mg	Capsule	100 mg / cap	Oral	Rhodiapharm Inc	1995-12-31	1996-09-09
Rho-doxycin Tabs - 100mg	Tablet	100 mg / tab	Oral	Rhodiapharm Inc	1995-12-31	1996-09-09
Rho-doxycycline - Cap 100mg	Capsule	100 mg / cap	Oral	Rhodiapharm Inc	1996-02-02	1998-08-05
Rho-doxycycline - Tab 100mg	Tablet	100 mg / tab	Oral	Rhodiapharm Inc	1996-12-31	1998-08-05
Sandoz Doxycycline		40 mg	Oral	Sandoz Canada Incorporated	Not applicable	Not applicable
Targadox	Tablet	50 mg/1	Oral	Journey Medical Corporation	2016-08-29	Not applicable
Teva-doxycycline	Capsule	100 mg	Oral	TEVA Canada Limited	1989-12-31	Not applicable
Teva-doxycycline	Tablet	100 mg	Oral	TEVA Canada Limited	1995-12-31	Not applicable

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
BenoxylDoxy 30 Kit	Doxycycline monohydrate (100 mg/1) + Benzoyl peroxide (44 mg/1mL)	Kit	Oral; Topical	Elorac, Inc.	2014-07-01	2014-08-07
BenoxylDoxy 60 Kit	Doxycycline monohydrate (100 mg/1) + Benzoyl peroxide (44 mg/1mL)	Kit	Oral; Topical	Elorac, Inc.	2014-07-01	2015-07-18
BenzoDox 30 Kit	Doxycycline monohydrate (100 mg/1) + Benzoyl peroxide (44 mg/1mL)	Kit	Oral; Topical	Elorac, Inc.	2015-10-01	Not applicable
BenzoDox 60 Kit	Doxycycline monohydrate (100 mg/1) + Benzoyl peroxide (44 mg/1mL)	Kit	Oral; Topical	Elorac, Inc.	2015-09-22	Not applicable
NicAzel Doxy Kit	Doxycycline monohydrate (100 mg/1) + Cupric oxide (2 mg/1) + Folic acid (500 ug/1) + Pyridoxine (8 mg/1) + Zinc oxide (12 mg/1)	Kit	Oral	Elorac, Inc.	2014-06-30	2015-07-30

Chemical Identifiers

UNII: 334895S862
CAS number: 564-25-0
InChI Key: JBIWCJUYHHGXTC-AKNGSSGZSA-N
InChI: InChI=1S/C22H24N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31)/t7-,10+,14+,15-,17-,22-/m0/s1
IUPAC Name: (4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
SMILES: [H][C@@]12[C@@H](C)C3=CC=CC(O)=C3C(=O)C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]1([H])[C@H]2O

References

Synthesis Reference

Dai-Wu Seol, "DNA cassette for the production of secretable recombinant trimeric TRAIL proteins, tetracycline/ doxycycline-inducible adeno-associated virus vector, their combination and use in gene therapy." U.S. Patent US20020128438, issued September 12, 2002.

US20020128438

General References

Hoerauf A, Mand S, Fischer K, Kruppa T, Marfo-Debrekyei Y, Debrah AY, Pfarr KM, Adjei O, Buttner DW: Doxycycline as a novel strategy against bancroftian filariasis-depletion of Wolbachia endosymbionts from Wuchereria bancrofti and stop of microfilaria production. Med Microbiol Immunol. 2003 Nov;192(4):211-6. Epub 2003 Mar 5. [Article]
Taylor MJ, Makunde WH, McGarry HF, Turner JD, Mand S, Hoerauf A: Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo-controlled trial. Lancet. 2005 Jun 18-24;365(9477):2116-21. [Article]
Bernatova S, Samek O, Pilat Z, Sery M, Jezek J, Jakl P, Siler M, Krzyzanek V, Zemanek P, Hola V, Dvorackova M, Ruzicka F: Following the mechanisms of bacteriostatic versus bactericidal action using Raman spectroscopy. Molecules. 2013 Oct 24;18(11):13188-99. doi: 10.3390/molecules181113188. [Article]
Valentin S, Morales A, Sanchez JL, Rivera A: Safety and efficacy of doxycycline in the treatment of rosacea. Clin Cosmet Investig Dermatol. 2009 Aug 12;2:129-40. [Article]
Smilack JD: The tetracyclines. Mayo Clin Proc. 1999 Jul;74(7):727-9. doi: 10.4065/74.7.727. [Article]
Chopra I, Roberts M: Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiol Mol Biol Rev. 2001 Jun;65(2):232-60 ; second page, table of contents. [Article]
Shutter MC, Akhondi H: Tetracycline . [Article]
Patel RS, Parmar M: Doxycycline Hyclate . [Article]
Bonnetblanc JM: [Doxycycline]. Ann Dermatol Venereol. 2002 Jun-Jul;129(6-7):874-82. [Article]
Agwuh KN, MacGowan A: Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines. J Antimicrob Chemother. 2006 Aug;58(2):256-65. Epub 2006 Jul 1. [Article]
FDA Approved Drug Products: DORYX (doxycycline hyclate) delayed-release tablets, for oral use [Link]
DailyMed Label: LYMEPAK (doxycycline hyclate) tablets, for oral use [Link]
DailyMed Label: VIBRAMYCIN and VIBRA-TABS (doxycycline), for oral use [Link]
Merck: Doxycycline MSDS [Link]

External Links

Human Metabolome Database: HMDB0014399
KEGG Drug: D07876
KEGG Compound: C06973
PubChem Compound: 54671203
PubChem Substance: 46506491
ChemSpider: 10469369
BindingDB: 50041429
RxNav: 1545992
ChEBI: 50845
ChEMBL: CHEMBL1433
ZINC: ZINC000016052277
Therapeutic Targets Database: DAP001371
PharmGKB: PA449415
PDBe Ligand: DXT
RxList: RxList Drug Page
Drugs.com: Drugs.com Drug Page
Wikipedia: Doxycycline

PDB Entries

2o7o / 2xrl / 5om2 / 5om3 / 6rbl / 6rcr / 6rgx / 7b8r / 7x5p

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
4	Active Not Recruiting	Prevention	Chlamydia Trachomatis Infection / Human Immunodeficiency Virus (HIV) Infections / Human Immunodeficiency Virus Infection(HIV)/Acquired Immunodeficiency Syndrome (AIDS) / Neisseria Gonorrheae Infection / Syphilis Infection	1
4	Active Not Recruiting	Prevention	Chlamydial Infections / Gonorrhea / Syphilis	1
4	Active Not Recruiting	Prevention	Sexually Transmitted Infections (STIs) / Syphilis	1
4	Completed	Basic Science	Bacterial Infections	1
4	Completed	Basic Science	Rabies	1
4	Completed	Prevention	Endometritis	1
4	Completed	Prevention	Medically induced abortion / Vomiting	1
4	Completed	Prevention	Sexually Transmitted Disease (STD)	1
4	Completed	Supportive Care	Rosacea	1
4	Completed	Treatment	Acne	2
4	Completed	Treatment	Acne Vulgaris	4
4	Completed	Treatment	Acne Vulgaris / Pediatric	1
4	Completed	Treatment	Adhesive Capsulitis of Shoulder / Adhesive Capsulitis of Unspecified Shoulder / Capsulitis, Adhesive	1
4	Completed	Treatment	Anal chlamydia infection	1
4	Completed	Treatment	Blepharitis	1
4	Completed	Treatment	Borrelia Infections / Lyme Disease	1
4	Completed	Treatment	Borreliosis / Early Lyme Disease / Erythema Chronicum Migrans / Lyme Disease	1
4	Completed	Treatment	Chronic Fatigue Syndrome/ Myalgic Encephalitis (CFS/ME) / Coxiella Infection / Q Fever	1
4	Completed	Treatment	Chronic Obstructive Pulmonary Disease (COPD)	1
4	Completed	Treatment	Coronavirus Disease 2019 (COVID‑19)	1
4	Completed	Treatment	Cystic Fibrosis (CF)	1
4	Completed	Treatment	Diabetes Mellitus	1
4	Completed	Treatment	Duodenal Ulcer Due to Helicobacter Pylori	1
4	Completed	Treatment	Epistaxis	1
4	Completed	Treatment	Erythema Chronicum Migrans / Post-Lyme Disease Symptoms	1
4	Completed	Treatment	Fever	1
4	Completed	Treatment	Filarial; Infestation	1
4	Completed	Treatment	Gonorrhea	1
4	Completed	Treatment	Helicobacter Pylori Infection	1
4	Completed	Treatment	Lymphangioleiomyomatosis (LAM) / Tuberous Sclerosis Complex (TSC)	1
4	Completed	Treatment	Multiple Sclerosis	1
4	Completed	Treatment	Neuroborreliosis, Lyme	1
4	Completed	Treatment	Obesity / Type 2 Diabetes Mellitus	1
4	Completed	Treatment	Overactive Bladder Syndrome (OABS)	1
4	Completed	Treatment	Papulopustular Rosacea (PPR)	2
4	Completed	Treatment	Periodontal Disease / Type 2 Diabetes Mellitus	1
4	Completed	Treatment	Rosacea	4
4	Completed	Treatment	Sinusitis	1
4	Completed	Treatment	Traumatic Brain Injury (TBI)	1
4	Completed	Treatment	Ulcerative Colitis	1
4	Enrolling by Invitation	Prevention	Autoimmune Disorder / Chronic Kidney Disease (CKD) / Diabetes / Inflammatory Diseases / MRSA / MSSA Colonization / Overweight or Obesity / Prosthetic Joint Infections / Tobacco Use	1
4	Enrolling by Invitation	Treatment	Bone and Joint Infections / Endovascular Infection / Gastrointestinal Tract Infections / Genitourinary tract infection / Pulmonary Infections / Skin and Soft Tissue Infections (SSTIs)	1
4	Not Yet Recruiting	Prevention	Bacteremia / Endocarditis	1
4	Not Yet Recruiting	Prevention	Chlamydial Infections / Gonorrhea / Sexually Transmitted Diseases, Bacterial / Syphilis	1
4	Recruiting	Prevention	Coronavirus Disease 2019 (COVID‑19) / Human Immunodeficiency Virus (HIV) Infections / STIs	1
4	Recruiting	Prevention	Sexually Transmitted Disease (STD)	1
4	Recruiting	Prevention	Sexually Transmitted Diseases, Bacterial	1
4	Recruiting	Supportive Care	Antimicrobial Resistance / Ocular Rosacea	1
4	Recruiting	Treatment	Acne	1
4	Recruiting	Treatment	Acneiform eruption / Treatment Related Cancer	1
4	Recruiting	Treatment	Central Centrifugal Cicatricial Alopecia (CCCA)	1
4	Recruiting	Treatment	Chlamydial Infections	1
4	Recruiting	Treatment	Coronavirus Disease 2019 (COVID‑19)	2
4	Recruiting	Treatment	Dry Eye Syndrome (DES) / Meibomian Gland Dysfunction (Disorder)	1
4	Recruiting	Treatment	Early Syphilis	1
4	Recruiting	Treatment	Helicobacter Pylori Infection	4
4	Recruiting	Treatment	Scrub Typhus	1
4	Terminated	Treatment	Advanced Malignant Neoplasm / Malignant Pleural Effusion	1
4	Terminated	Treatment	Chronic Pelvic Pain Syndrome (CPPS) / Painful Bladder Syndrome (PBS)	1
4	Terminated	Treatment	Periodontitis	1
4	Terminated	Treatment	Septic Abortion	1
4	Unknown Status	Prevention	Human Immunodeficiency Virus (HIV) Infections / Syphilis	1
4	Unknown Status	Supportive Care	Community Acquired Pneumonia (CAP)	1
4	Unknown Status	Treatment	Anal infection / Chlamydia Trachomatis Infection / Vaginal Infections	1
4	Unknown Status	Treatment	Cervicitis / Chlamydia Trachomatis / Genital Mycoplasma Infection / Urethritis	1
4	Unknown Status	Treatment	Chronic Obstructive Pulmonary Disease (COPD) / Inflammation / Pulmonary Emphysema	1
4	Unknown Status	Treatment	Endometrial Bleeding / Periodontal Disease	1
4	Unknown Status	Treatment	Helicobacter Pylori Infection	2
4	Withdrawn	Prevention	Cardiovascular Disease (CVD)	1
4	Withdrawn	Treatment	Chronic Obstructive Pulmonary Disease (COPD)	1
3	Active Not Recruiting	Treatment	Risk-Taking / Unsafe Sex	1
3	Completed	Diagnostic	Neuroborreliosis, Lyme	1
3	Completed	Diagnostic	Periodontitis / Type 2 Diabetes Mellitus	1
3	Completed	Prevention	Coronavirus Disease 2019 (COVID‑19)	1
3	Completed	Supportive Care	Metastatic Cancer	1
3	Completed	Treatment	Acne	1
3	Completed	Treatment	Acne Vulgaris	1
3	Completed	Treatment	Adrenal androgen excess / Menstrual Irregularities / Polycystic Ovarian Syndrome (PCOS)	1
3	Completed	Treatment	Alzheimer's Disease (AD)	1
3	Completed	Treatment	Chlamydial Infections	1
3	Completed	Treatment	Chronic Obstructive Pulmonary Disease (COPD)	1
3	Completed	Treatment	Chronic Periodontitis (Disorder)	1
3	Completed	Treatment	Coronavirus Disease 2019 (COVID‑19)	1
3	Completed	Treatment	ESI-related Bleeding	1
3	Completed	Treatment	Filariasis / Filariasis, Lymphatic / Lymphedema	3
3	Completed	Treatment	Lyme Disease	2
3	Completed	Treatment	Neuroborreliosis, Borrelia Burgdorferi	1
3	Completed	Treatment	Osteoarthritis (OA)	1
3	Completed	Treatment	Papulopustular Rosacea (PPR)	2
3	Completed	Treatment	Periodontal Disease / Type 2 Diabetes Mellitus	1
3	Completed	Treatment	Periodontitis	1
3	Completed	Treatment	Reactive Arthritis / Reiter's Disease	1
3	Completed	Treatment	Rosacea	2
3	Completed	Treatment	Scrub Typhus	1
3	Completed	Treatment	Severe Acne Vulgaris	1
3	Completed	Treatment	Syphilis	1
3	Completed	Treatment	TTR Cardiac Amyloidosis	1
3	Completed	Treatment	Urethritis	1
3	Completed	Treatment	Urogential Chlamydia Trachomatis Infection	1
3	Completed	Treatment	Uterine Hemorrhage	1
3	Enrolling by Invitation	Treatment	Joint Infection	1
3	Not Yet Recruiting	Treatment	Chronic Rhinosinusitis Phenotype With Nasal Polyps (CRSwNP) / Nasal Polyps	1
3	Recruiting	Treatment	Cutaneous Leishmaniasis	1
3	Recruiting	Treatment	Rocky Mountain Spotted Fever	1
3	Recruiting	Treatment	Syphilis	1
3	Recruiting	Treatment	Tuberculosis (TB)	1
3	Terminated	Treatment	Idiopathic Pulmonary Fibrosis (IPF)	1
3	Unknown Status	Not Available	Chronic Obstructive Pulmonary Disease (COPD)	1
3	Unknown Status	Treatment	Alzheimer's Disease (AD)	1
3	Unknown Status	Treatment	Dyspepsia	1
3	Unknown Status	Treatment	Heart Failure / Myocardial Infarction, Anterior Wall / ST Segment Elevation Myocardial Infarction (STEMI) / Ventricular Remodelling	1
3	Unknown Status	Treatment	Helicobacter-associated Gastritis	1
3	Unknown Status	Treatment	Lymphoma	1
3	Unknown Status	Treatment	Oral Antibiotics / Periprosthetic Infection / Revision Total Shoulder Arthroplasty	1
3	Withdrawn	Treatment	Cancer / Overall Survivals	1
3	Withdrawn	Treatment	Coronavirus Disease 2019 (COVID‑19)	1
3	Withdrawn	Treatment	Coronavirus Disease 2019 (COVID‑19) / Patients Hospitalized	1
2	Active Not Recruiting	Treatment	Breast Carcinoma / Endometrial Clear Cell Adenocarcinoma / Endometrial Papillary Serous Carcinoma / Uterine Carcinosarcoma / Uterine Corpus Cancer	1
2	Active Not Recruiting	Treatment	Hereditary Haemorrhagic Telangiectasia (HHT)	1
2	Active Not Recruiting	Treatment	Larynx / Lips / Oral Cavity / Pharynx	1
2	Active Not Recruiting	Treatment	Marginal Zone Lymphoma of Ocular Adnexal	1
2	Active Not Recruiting	Treatment	Urticaria	1
2	Completed	Not Available	Dry Eyes	1
2	Completed	Basic Science	Abdominal Aortic Aneurysm (AAA)	1
2	Completed	Prevention	Anthrax	1
2	Completed	Prevention	Cardiopulmonary Bypass / Coronary Artery Bypass Grafting (CABG) / Reperfusion Injury	1
2	Completed	Prevention	Co-Infection / Mansonella Perstans Infection / Mycobacterium marinum infection / Tuberculosis (TB)	1
2	Completed	Prevention	Insomnia, Fatal Familial	1
2	Completed	Prevention	RAS Wild Type Colorectal Cancer	1
2	Completed	Prevention	Rash Due to Epidermal Growth Factor Receptor Inhibitors	1
2	Completed	Supportive Care	Advanced Malignant Neoplasm / Dermatologic Complications	1
2	Completed	Treatment	Acne	1
2	Completed	Treatment	Acne Vulgaris	2
2	Completed	Treatment	Amyloidosis	1
2	Completed	Treatment	Aneurysms	1
2	Completed	Treatment	Atopic Dermatitis	1
2	Completed	Treatment	Blepharitis / Dry Eyes / Meibomianitis	1
2	Completed	Treatment	Cardiomyopathy / Transthyretin Amyloidosis	1
2	Completed	Treatment	Chlamydia Trachomatis Infection / Gonorrhea	1
2	Completed	Treatment	Chronic Periodontitis (Disorder)	2
2	Completed	Treatment	Chronic Sinusitis / Nasal Polyps	1
2	Completed	Treatment	Colorectal Cancer / Head And Neck Cancer	1
2	Completed	Treatment	Coronavirus Disease 2019 (COVID‑19) / COVID19 Patients	1
2	Completed	Treatment	Crohn's Disease (CD)	1
2	Completed	Treatment	Cystic Fibrosis (CF)	1
2	Completed	Treatment	Diabetic Foot Ulcers (DFUs)	1
2	Completed	Treatment	Diabetic Retinopathy (DR)	2
2	Completed	Treatment	Mansonella Perstans Infection / Mp Microfilaremia	1
2	Completed	Treatment	Myocardial Infarction / Ventricular Remodeling, Left	1
2	Completed	Treatment	Non-Hodgkin's Lymphoma (NHL)	1
2	Completed	Treatment	Non-Small Cell Lung Cancer (NSCLC)	1
2	Completed	Treatment	Oral Lichen Planus	1
2	Completed	Treatment	Pain	1
2	Completed	Treatment	Pelvic Inflammatory Disease (PID)	2
2	Completed	Treatment	Periodontal Disease / Periodontitis	1
2	Completed	Treatment	Posterior Blepharitis	1
2	Completed	Treatment	Primary Amyloidosis	1
2	Completed	Treatment	Resectable Pancreatic Cancer	1
2	Completed	Treatment	Rosacea	1
2	Completed	Treatment	Skin Toxicity	1
2	Completed	Treatment	Transthyretin Amyloidosis	1
2	Completed	Treatment	Tuberculosis (TB)	1
2	Completed	Treatment	Ulcerative Colitis	1
2	Completed	Treatment	Urethritis	1
2	Recruiting	Prevention	Heart Failure / ST Segment Elevation Myocardial Infarction (STEMI)	1
2	Recruiting	Treatment	Acne Vulgaris	1
2	Recruiting	Treatment	Atopic Dermatitis / Dermatitis / Skin Diseases / Skin Diseases, Genetic	1
2	Recruiting	Treatment	Autoimmune Disorder / Endocrine System Diseases / Eye Diseases, Hereditary / Graves' Disease / Hyperthyroidism / Immune System Diseases / Thyroid Associated Ophthalmopathy / Thyroid Eye Disease / Thyroid Gland Diseases	1
2	Recruiting	Treatment	Emphysema / Human Immunodeficiency Virus (HIV) Infections	1
2	Recruiting	Treatment	Exudative Macular Degeneration / Neovascular Age-Related Macular Degeneration (nAMD)	1
2	Recruiting	Treatment	Methicillin Resistant Staphylococcus Aureus (MRSA) / Skin Infections	1
2	Recruiting	Treatment	Non-Small Cell Lung Carcinoma	1
2	Recruiting	Treatment	Parkinson's Disease (PD)	1
2	Recruiting	Treatment	Wounds and Injuries	1
2	Terminated	Treatment	Adult Diffuse Large B-Cell Lymphoma / Chronic Lymphocytic Leukemia / Follicular Lymphoma ( FL) / Malignant Lymphoma - Lymphoplasmacytic / Marginal Zone B-Cell Lymphoma / Recurrent Mantle Cell Lymphoma / Small Lymphocytic Lymphoma / T-Cell Lymphoma / Waldenström's Macroglobulinemia (WM)	1
2	Terminated	Treatment	Chlamydophila Pneumoniae Infections / Coronary Heart Disease (CHD)	1
2	Terminated	Treatment	Colorectal Carcinoma (CRC)	1
2	Terminated	Treatment	Cutaneous T-Cell Lymphoma (CTCL) / Mycosis Fungoides (MF) / Sezary Syndrome	1
2	Terminated	Treatment	Minor Intra-uterine Abnormalities	1
2	Terminated	Treatment	Nasal Polyps	1
2	Terminated	Treatment	Non Ischemic Cardiomyopathy / Systolic Heart Failure (NYHA II-III)	1
2	Terminated	Treatment	Ulcerative Colitis	1
2	Unknown Status	Prevention	Mucositis	1
2	Unknown Status	Treatment	Acne	1
2	Unknown Status	Treatment	Aneurysm, Coronary / Mucocutaneous Lymph Node Syndrome	1
2	Unknown Status	Treatment	Coronavirus Disease 2019 (COVID‑19)	1
2	Unknown Status	Treatment	Malignant Pleural Effusion	1
2	Unknown Status	Treatment	Marfan Syndrome	1
2	Unknown Status	Treatment	Plague	1
2	Unknown Status	Treatment	Seizures	1
2	Withdrawn	Treatment	Coronavirus Disease 2019 (COVID‑19) / Cytokine Storm	1
2, 3	Completed	Not Available	Jarisch Herxheimer Reaction / Relapsing Fever, Tick-Borne	1
2, 3	Completed	Treatment	Chronic Periodontitis (Disorder)	1
2, 3	Completed	Treatment	Coronavirus Disease 2019 (COVID‑19) / CoVid 19 Positive	1
2, 3	Completed	Treatment	Diabetes Mellitus With Periodontal Disease	1
2, 3	Completed	Treatment	Dry Macular Degeneration	1
2, 3	Not Yet Recruiting	Treatment	Infectious Diseases / Therapeutics	1
2, 3	Not Yet Recruiting	Treatment	Sexually Transmitted Disease (STD)	1
2, 3	Recruiting	Treatment	Pulmonary Disease Due to Mycobacteria (Diagnosis)	1
2, 3	Terminated	Treatment	Cardiac AL Amyloidosis	1
2, 3	Unknown Status	Treatment	Acne / Inflammation	1
2, 3	Unknown Status	Treatment	Acute Myocardial Infarction (AMI) / Cardiovascular Disease (CVD) / Vascular Diseases	1
2, 3	Unknown Status	Treatment	Eye Burns	1
1	Active Not Recruiting	Other	Lateral Epicondylitis / Lateral Epicondylitis (Tennis Elbow) Bilateral / Lateral Epicondylitis, Left Elbow / Lateral Epicondylitis, Right Elbow / Lateral Epicondylitis, Unspecified Elbow / Medial Epicondylitis / Medial Epicondylitis, Left Elbow / Medial Epicondylitis, Right Elbow	1
1	Active Not Recruiting	Treatment	Coronavirus Disease 2019 (COVID‑19) / COVID / Infections, Coronavirus / Seasonal Allergic Rhinitis	1
1	Active Not Recruiting	Treatment	Gastrointestinal neoplasms malignant NEC / Malignant Breast Neoplasm / Malignant Neoplasms of Eye, Brain and Other Parts of Central Nervous System / Malignant Neoplasms of Female Genital Organs / Malignant Neoplasms of Ill-defined Secondary and Unspecified Sites / Malignant Neoplasms of Independent (Primary) Multiple Sites / Malignant Neoplasms of Lip Oral Cavity and Pharynx / Malignant Neoplasms of Male Genital Organs / Malignant Neoplasms of Mesothelial and Soft Tissue / Malignant Neoplasms of Respiratory and Intrathoracic Organs / Malignant Neoplasms of Thyroid and Other Endocrine Glands / Malignant Neoplasms of Urinary Tract	1
1	Completed	Not Available	Healthy Volunteers (HV)	2
1	Completed	Not Available	To Determine Bioequivalence Under Fasting Conditions	3
1	Completed	Basic Science	Bacterial Infections / Fungal Infections / Healthy Volunteers (HV)	1
1	Completed	Basic Science	Healthy Volunteers (HV)	1
1	Completed	Other	Healthy Volunteers (HV)	2
1	Completed	Other	Rosacea	1
1	Completed	Other	To Determine Bioequivalence Under Fed Conditions	2
1	Completed	Prevention	Arteriovenous Malformations / Cavernous Angiomas / Intracranial Aneurysms	1
1	Completed	Prevention	Cardiorenal Syndrome (CRS) / Chronic Kidney Disease (CKD)	1
1	Completed	Treatment	Acne Vulgaris	1
1	Completed	Treatment	Aneurysms / Arteriovenous Malformations	1
1	Not Yet Recruiting	Treatment	Controlled Human Malaria Infection (CHMI) / Induced Blood Stage Malaria Infection / Malaria Challenge / Malaria Transmission	1
1	Not Yet Recruiting	Treatment	Rhinoscleroma	1
1	Recruiting	Other	Cerebral Hemorrhage / Hydrocephaly / Subarachnoid Hemorrhage / Ventriculitis, Cerebral	1
1	Terminated	Treatment	Anthrax	1
1, 2	Active Not Recruiting	Health Services Research	Acne Vulgaris	1
1, 2	Completed	Treatment	Amyloidosis; Heart (Manifestation) / Senile Cardiac Amyloidosis	1
1, 2	Completed	Treatment	Autoimmune Disorder / Endocrine System Diseases / Eye Diseases / Eye Diseases, Hereditary / Graves' Disease / Hyperthyroidism / Immune System Diseases / Thyroid Eye Disease / Thyroid Gland Diseases	1
1, 2	Completed	Treatment	Coronavirus Disease 2019 (COVID‑19)	1
1, 2	Completed	Treatment	Periodontitis, Aggressive	1
1, 2	Not Yet Recruiting	Treatment	Type 2 Diabetes Mellitus	1
1, 2	Recruiting	Treatment	Neurofibromatosis, type 2 (acoustic neurofibromatosis)	1
1, 2	Terminated	Treatment	Diabetic Foot Ulcers (DFUs)	1
1, 2	Terminated	Treatment	Melanoma	1
1, 2	Terminated	Treatment	Mycoplasma genitalium infection	1
1, 2	Unknown Status	Treatment	Acne Vulgaris	1
0	Active Not Recruiting	Prevention	Erectile Dysfunction / Penile Prosthesis Infection	1
0	Completed	Other	Cutaneous Rosacea / Ocular Rosacea / Rosacea	1
0	Not Yet Recruiting	Basic Science	Sexually Transmitted Diseases, Bacterial	1
0	Recruiting	Basic Science	Rosacea	1
0	Terminated	Treatment	Osteomyelitis	1
0	Unknown Status	Treatment	Cutaneous T-Cell Lymphoma (CTCL)	1
0	Unknown Status	Treatment	Oral Lichen Planus	1
Not Available	Active Not Recruiting	Not Available	STIs Prevention	1
Not Available	Completed	Not Available	Bullous Pemphigoid (BP)	1
Not Available	Completed	Not Available	Cirrhosis of the Liver / Spontaneous Bacterial Peritonitis (SBP)	1
Not Available	Completed	Not Available	Coronavirus Disease 2019 (COVID‑19) / Hydroxychloroquine / Ivermectin	1
Not Available	Completed	Not Available	Drug Induced Liver Injury	1
Not Available	Completed	Not Available	Head And Neck Cancer	1
Not Available	Completed	Not Available	Healthy Volunteers (HV)	2
Not Available	Completed	Not Available	Mycoplasma Pneumoniae	1
Not Available	Completed	Not Available	Neuroborreliosis, Lyme	1
Not Available	Completed	Not Available	Pemphigus, Benign Familial	1
Not Available	Completed	Not Available	Periodontal Disease / Psoriatic Arthritis / Rheumatoid Arthritis	1
Not Available	Completed	Basic Science	Cognitive Dysfunctions / Fatigue / Paresis / Paresthesia / Radicular Pain	1
Not Available	Completed	Basic Science	Erythema Chronicum Migrans	1
Not Available	Completed	Health Services Research	Umbilical Granuloma	1
Not Available	Completed	Other	Erythema Chronicum Migrans	1
Not Available	Completed	Prevention	Abortion in First Trimester	1
Not Available	Completed	Prevention	Methicillin Resistant Staphylococcus Aureus Skin Infections	1
Not Available	Completed	Prevention	Osteoarthritis (OA)	1
Not Available	Completed	Prevention	Syphilis	1
Not Available	Completed	Treatment	Acne Vulgaris / Diet Modification	1
Not Available	Completed	Treatment	Amyloidosis; Systemic	1
Not Available	Completed	Treatment	Aortic Aneurysms	1
Not Available	Completed	Treatment	Breakthrough Bleeding	1
Not Available	Completed	Treatment	Chronic Obstructive Pulmonary Disease (COPD) / Emphysema / Human Immunodeficiency Virus (HIV) Infections	1
Not Available	Completed	Treatment	Cystic Fibrosis (CF)	1
Not Available	Completed	Treatment	Diabetes Mellitus With Periodontal Disease	1
Not Available	Completed	Treatment	Diabetes Mellitus / Peridontal Disease / Poor Glycemic Control	1
Not Available	Completed	Treatment	Erythema Chronicum Migrans	2
Not Available	Completed	Treatment	Exacerbation of Ulcerative Colitis / Granulomatous Colitis / Ulcerative Colitis, Active Severe	1
Not Available	Completed	Treatment	Gastritis	1
Not Available	Completed	Treatment	Infection	1
Not Available	Completed	Treatment	Malaria	1
Not Available	Completed	Treatment	Methicillin Resistant Staphylococcus Aureus (MRSA)	1
Not Available	Completed	Treatment	Oral Contraceptives	1
Not Available	Completed	Treatment	Prosthetic Joint Infections	1
Not Available	Completed	Treatment	Rheumatoid Arthritis	1
Not Available	Completed	Treatment	Rosacea	1
Not Available	Completed	Treatment	Scrub Typhus	1
Not Available	Completed	Treatment	Ulcerative Colitis	1
Not Available	Not Yet Recruiting	Not Available	Coronavirus Disease 2019 (COVID‑19)	1
Not Available	Not Yet Recruiting	Treatment	Early Syphilis, Latent, Serological Relapse After Treatment	1
Not Available	Not Yet Recruiting	Treatment	Helicobacter Pylori Infection	1
Not Available	Not Yet Recruiting	Treatment	Relapsing Fever, Tick-Borne	1
Not Available	Recruiting	Not Available	Breastfed Infants of Mothers on Select DOI / Lactating Women on Select DOI	1
Not Available	Recruiting	Not Available	Pleural Neoplasms	1
Not Available	Recruiting	Basic Science	Erythema Chronicum Migrans	1
Not Available	Recruiting	Prevention	Female Infertility / Pelvic Inflammatory Disease (PID)	1
Not Available	Recruiting	Screening	Thyroid Associated Ophthalmopathy	1
Not Available	Recruiting	Treatment	Dry socket syndrome / Osteitis	1
Not Available	Recruiting	Treatment	Erythema Chronicum Migrans	1
Not Available	Recruiting	Treatment	Helicobacter Pylori Infection	2
Not Available	Recruiting	Treatment	MRSA	1
Not Available	Recruiting	Treatment	Pneumonia Atypical	1
Not Available	Recruiting	Treatment	Pneumonia, Mycoplasma	1
Not Available	Recruiting	Treatment	Tick Borne Encephalitis (TBE)	1
Not Available	Terminated	Prevention	Motility Disorders / Staphylococcus Aureus	1
Not Available	Terminated	Treatment	Metastatic Colorectal Cancer (CRC) / Skin Toxicity	1
Not Available	Terminated	Treatment	Septic Abortion	1
Not Available	Terminated	Treatment	Ulcerative Colitis	1
Not Available	Unknown Status	Not Available	Meningitis, Aseptic	1
Not Available	Unknown Status	Basic Science	Chronic Atrophic Acrodermatitis	1
Not Available	Unknown Status	Prevention	Propionibacterium	1
Not Available	Unknown Status	Treatment	Infertility	1
Not Available	Unknown Status	Treatment	Lateral Epicondylalgia (Tennis Elbow)	1
Not Available	Unknown Status	Treatment	Multiple Erythema Migrans	1
Not Available	Unknown Status	Treatment	Suspected Early Lyme Neuroborreliosis	1
Not Available	Unknown Status	Treatment	Tick Borne Encephalitis (TBE)	1
Not Available	Withdrawn	Prevention	Seroma	1
Not Available	Withdrawn	Supportive Care	Non-Small Cell Lung Cancer (NSCLC)	1
Not Available	Withdrawn	Treatment	Dehisced Surgical Wounds	1
Not Available	Withdrawn	Treatment	Dry Eye Syndrome (DES)	1
Not Available	Withdrawn	Treatment	Headache Disorders, Primary / Migraine / Migraine With Aura / Migraine Without Aura	1
Not Available	Withdrawn	Treatment	Rotator Cuff Injuries	1

Pharmacoeconomics

Manufacturers

Mylan pharmaceuticals inc
Par pharmaceutical inc
Ranbaxy laboratories ltd
Sandoz inc
Watson laboratories inc
Watson pharmaceuticals inc
Galderma laboratories lp
Rachelle laboratories inc
Ivax pharmaceuticals inc sub teva pharmaceuticals usa
Pfizer laboratories div pfizer inc
Lannett holdings inc
Mutual pharmaceutical co inc
Pliva inc
Mayne pharma international faulding pharm
Warner chilcott bermuda ltd
Medicis pharmaceutical corp
Halsey drug co inc
Heather drug co inc
Interpharm inc
Private formulations inc
Ranbaxy pharmaceuticals inc
Superpharm corp
Warner chilcott div warner lambert co
West ward pharmaceutical corp
Teva pharmaceuticals usa inc
Collagenex inc
App pharmaceuticals llc
Baxter healthcare corp anesthesia and critical care
Bedford laboratories div ben venue laboratories inc
Tolmar inc
Corepharma llc
Larken laboratories inc
Mutual pharmacal co
Truxton inc
Vintage pharmaceuticals inc

Packagers

Actavis Group
Acura Pharmaceutical Technologies Inc.
Advanced Pharmaceutical Services Inc.
Advanced Vision Research
Aidarex Pharmacuticals LLC
Amerisource Health Services Corp.
Amneal Pharmaceuticals
Apace Packaging
Apical Pharmaceutical Corporation
Apotheca Inc.
Apothecon
APP Pharmaceuticals
Aqua Pharmaceuticals
A-S Medication Solutions LLC
Avidas Pharmaceuticals
Bedford Labs
Belgomex Sprl
Ben Venue Laboratories Inc.
Bioglan Pharmaceuticals Co.
Blenheim Pharmacal
Block Drug Corp.
Blu Pharmaceuticals LLC
Bryant Ranch Prepack
Bv Pharbita
Cardinal Health
Carlisle Laboratories Inc.
Catalent Pharma Solutions
Collagenex Pharmaceuticals Inc.
Community Action Inc. Community Health Services
Comprehensive Consultant Services Inc.
Corepharma LLC
Coupler Enterprises Inc.
Darby Dental Supply Co. Inc.
Dept Health Central Pharmacy
DHHS Program Support Center Supply Service Center
Direct Dispensing Inc.
Dispensing Solutions
Diversified Healthcare Services Inc.
DSM Corp.
Eon Labs
Galderma Laboratories
Golden State Medical Supply Inc.
Goldline Laboratories Inc.
H and H Laboratories
H.J. Harkins Co. Inc.
Hikma Pharmaceuticals
Innoviant Pharmacy Inc.
Ivax Pharmaceuticals
Kaiser Foundation Hospital
Keltman Pharmaceuticals Inc.
Lake Erie Medical and Surgical Supply
Lannett Co. Inc.
Liberty Pharmaceuticals
Major Pharmaceuticals
Mayne Pharma International Pty Ltd.
Mckesson Corp.
Medisca Inc.
Medvantx Inc.
Mississippi State Dept Health
Murfreesboro Pharmaceutical Nursing Supply
Mutual Pharmaceutical Co.
Mylan
Nucare Pharmaceuticals Inc.
Oclassen Pharmaceuticals Inc.
Ohm Laboratories Inc.
Palmetto Pharmaceuticals Inc.
Par Pharmaceuticals
Patheon Inc.
Patient First Corp.
PCA LLC
PD-Rx Pharmaceuticals Inc.
Pfizer Inc.
Pharmaceutical Manufacturing Research Services Inc.
Pharmaceutical Utilization Management Program VA Inc.
Pharmaderm
Pharmedix
Pharmpak Inc.
Physicians Total Care Inc.
Pliva Inc.
Preferred Pharmaceuticals Inc.
Prepackage Specialists
Prepak Systems Inc.
Qualitest
Ranbaxy Laboratories
Rebel Distributors Corp.
Redpharm Drug
Remedy Repack
Sandhills Packaging Inc.
Sandoz
Southwood Pharmaceuticals
St Mary's Medical Park Pharmacy
Stat Rx Usa
Teva Pharmaceutical Industries Ltd.
Tolmar Inc.
Tya Pharmaceuticals
Universal Laboratories Inc.
Veratex Corp.
Versapharm Inc.
Warner Chilcott Co. Inc.
Watson Pharmaceuticals
WC Pharmaceuticals
West-Ward Pharmaceuticals

Dosage Forms

Form	Route	Strength
Capsule	Oral	150 mg/1
Kit	Oral	50 mg/1
Kit	Oral	50 mg/500mg
Kit	Oral; Topical
Capsule, delayed release pellets	Oral	100 mg/1
Capsule, delayed release pellets	Oral	75 mg/1
Tablet, delayed release	Oral	150 mg/1
Tablet, delayed release	Oral	80 mg/1
Capsule, extended release	Oral	100 mg / cap
Tablet, delayed release	Oral	120 mg/1
Tablet, delayed release	Oral	60 mg/1
Tablet, film coated	Oral
Capsule, coated	Oral	40 mg
Capsule, coated	Oral	10000000 mg
Tablet	Oral	100 mg
Tablet	Oral	200 MG
Tablet, soluble	Oral
Tablet	Oral	200 mg/1
Capsule	Oral	200 mg/1
For suspension	Oral	25 mg/5mL
Injection, powder, for solution	Intravenous	100 mg/1
Injection, powder, lyophilized, for solution	Intravenous	100 mg/10mL
Injection, powder, lyophilized, for solution	Intravenous	200 mg/20mL
Powder, for suspension	Oral	25 mg/5mL
Tablet, coated	Oral	100 mg/1
Tablet, film coated	Oral	150 mg/1
Tablet, film coated	Oral	50 mg/1
Tablet, film coated	Oral	75 mg/1
Capsule	Oral	100 mg/1
Capsule	Oral	50 mg/1
Capsule, gelatin coated	Oral	100 mg/1
Capsule, gelatin coated	Oral	50 mg/1
Powder	Not applicable	1 g/1g
Tablet	Oral	100 mg/1
Tablet, coated	Oral	150 mg/1
Tablet, coated	Oral	75 mg/1
Tablet, delayed release	Oral	100 mg/1
Tablet, delayed release	Oral	200 mg/1
Tablet, delayed release	Oral	50 mg/1
Tablet, delayed release	Oral	75 mg/100mg
Tablet, delayed release	Oral	75 mg/1
Tablet, film coated	Oral	100 1/1
Tablet, film coated	Oral	100 mg/1
Tablet, film coated	Oral	20 mg/1
Tablet	Oral	150 mg/1
Tablet	Oral	50 mg/1
Tablet	Oral	75 mg/1
Tablet, film coated	Oral	50 mg
Tablet, film coated	Oral	200 mg
Tablet, coated	Oral
Tablet	Oral
Capsule	Oral	40 MG
Capsule, coated	Oral	100 mg
Capsule	Oral
Capsule	Oral	50.000 mg
Gel	Periodontal	140 mg/g
Capsule	Oral	50 mg/50mg
Capsule	Oral	100 mg/100mg
Capsule	Oral	75 mg/1
Capsule	Oral; Topical	50 mg/1
Kit	Oral
Capsule	Oral	40 mg/1
Capsule, delayed release pellets	Oral	40 mg/1
Capsule, extended release	Oral	40 mg
Capsule, delayed release	Oral	40 mg
Capsule	Oral	20 mg
Tablet	Oral	20 mg/1
Capsule	Oral	100 mg / cap
Tablet	Oral	100 mg / tab
Capsule	Oral	100.000 mg
Capsule	Oral	100 MG
Solution	Intravenous	25.370 mg
Syrup	Oral	50 mg/5mL
Powder	Intravenous	100 mg / vial
Solution	Intravenous	100 mg/5ml
Tablet, delayed release	Oral	100 mg
Tablet, film coated	Oral	100 mg

Prices

Unit description	Cost	Unit
Vibramycin 25 mg/5ml Suspension 60ml Bottle	36.29USD	bottle
Adoxa pak 1-150 mg tablet	19.93USD	tablet
Doryx 150 mg Enteric Coated Tabs	17.51USD	tab
Doryx dr 150 mg tablet	16.83USD	tablet
Doxycycline hyc 100 mg vial	14.16USD	vial
Adoxa 100 mg tablet	13.86USD	tablet
Monodox 100 mg capsule	13.46USD	capsule
Adoxa 75 mg tablet	12.77USD	tablet
Oracea 40 mg Delayed Release Capsule	12.44USD	capsule
Oracea 40 mg capsule	11.96USD	capsule
Avidoxy 100 mg tablet	11.52USD	tablet
Monodox 75 mg capsule	11.02USD	capsule
Doryx 100 mg Enteric Coated Tabs	10.31USD	tab
Doryx dr 100 mg tablet	9.91USD	tablet
Adoxa pak 1-100 mg tablet	9.88USD	tablet
Doxycycline Monohydrate 150 mg tablet	9.51USD	tablet
Adoxa 50 mg tablet	9.29USD	tablet
Doxycycline mono 150 mg tablet	9.13USD	tablet
Doryx 75 mg Enteric Coated Tabs	8.76USD	tab
Doryx dr 75 mg tablet	8.42USD	tablet
Vibramycin 100 mg capsule	6.67USD	capsule
Vibra-tabs 100 mg tablet	6.67USD	tablet
Monodox 50 mg capsule	6.0USD	capsule
Doxycycline mono 100 mg tablet	5.98USD	tablet
Periostat 20 mg tablet	5.75USD	tablet
Doxycycline mono 75 mg tablet	5.74USD	tablet
Doxycycline Monohydrate 100 mg tablet	5.12USD	tablet
Doxycycline mono 50 mg tablet	4.17USD	tablet
Doxycycline Monohydrate 50 mg tablet	3.0USD	tablet
Doxycycline hyclate powder	2.56USD	g
Vibramycin 50 mg capsule	2.41USD	capsule
Doxycycline Monohydrate 100 mg capsule	2.22USD	capsule
Vibramycin 100 mg Capsule	1.91USD	capsule
Doxycycline Monohydrate 50 mg capsule	1.51USD	capsule
Doxycycline hyclate 100 mg tablet	1.28USD	tablet
Doxycycline hyclate 20 mg tablet	1.28USD	tablet
Doxycycline Hyclate 100 mg capsule	1.18USD	capsule
Doxycycline Hyclate 50 mg capsule	0.76USD	capsule
Vibramycin 50 mg/5ml Syrup	0.67USD	ml
Vibramycin 50 mg/5 ml syrup	0.64USD	ml
Apo-Doxy 100 mg Capsule	0.61USD	capsule
Apo-Doxy 100 mg Tablet	0.61USD	tablet
Doxycin 100 mg Capsule	0.61USD	capsule
Doxycin 100 mg Tablet	0.61USD	tablet
Novo-Doxylin 100 mg Capsule	0.61USD	capsule
Novo-Doxylin 100 mg Tablet	0.61USD	tablet
Nu-Doxycycline 100 mg Capsule	0.61USD	capsule
Pms-Doxycycline 100 mg Capsule	0.61USD	capsule
Pms-Doxycycline 100 mg Tablet	0.61USD	tablet

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Patents

Patent Number	Pediatric Extension	Approved	Expires (estimated)
US6958161	No	2005-10-25	2022-12-15
US8715724	No	2014-05-06	2028-02-03
US7211267	No	2007-05-01	2022-04-05
US7232572	No	2007-06-19	2022-04-05
US7749532	No	2010-07-06	2027-12-19
US8206740	No	2012-06-26	2025-12-24
US8394405	No	2013-03-12	2024-04-07
US8394406	No	2013-03-12	2024-04-07
US8470364	No	2013-06-25	2024-04-07
US8603506	No	2013-12-10	2022-04-05
US5789395	No	1998-08-04	2016-08-30
US5919775	No	1999-07-06	2016-08-30
US8709478	No	2014-04-29	2024-04-07
US9241946	No	2016-01-26	2022-04-05
US9511031	No	2016-12-06	2034-10-23
US9446057	No	2016-09-20	2034-12-23
US9295652	No	2016-03-29	2034-10-23
US10058564	No	2018-08-28	2022-04-05

Properties

State

Solid

Experimental Properties

Property	Value	Source
melting point (°C)	201 °C	https://www.sigmaaldrich.com/content/dam/sigma-aldrich/docs/Sigma/Product_Information_Sheet/d9891pis.pdf
water solubility	50 mg/mL	https://www.sigmaaldrich.com/content/dam/sigma-aldrich/docs/Sigma/Product_Information_Sheet/d9891pis.pdf
logP	0.63	https://deepblue.lib.umich.edu/bitstream/handle/2027.42/64911/21954_ftp.pdf?sequence=1
pKa	3.09	https://www.ncbi.nlm.nih.gov/pubmed/34018

Predicted Properties

Property	Value	Source
Water Solubility	0.63 mg/mL	ALOGPS
logP	-0.72	ALOGPS
logP	-3.3	Chemaxon
logS	-2.8	ALOGPS
pKa (Strongest Acidic)	3.27	Chemaxon
pKa (Strongest Basic)	8.33	Chemaxon
Physiological Charge	0	Chemaxon
Hydrogen Acceptor Count	9	Chemaxon
Hydrogen Donor Count	6	Chemaxon
Polar Surface Area	181.62 Å²	Chemaxon
Rotatable Bond Count	2	Chemaxon
Refractivity	113.89 m³·mol^-1	Chemaxon
Polarizability	43.65 Å³	Chemaxon
Number of Rings	4	Chemaxon
Bioavailability	1	Chemaxon
Rule of Five	No	Chemaxon
Ghose Filter	No	Chemaxon
Veber's Rule	No	Chemaxon
MDDR-like Rule	No	Chemaxon

Predicted ADMET Features

Property	Value	Probability
Human Intestinal Absorption	+	0.85
Blood Brain Barrier	-	0.9881
Caco-2 permeable	-	0.8706
P-glycoprotein substrate	Substrate	0.699
P-glycoprotein inhibitor I	Non-inhibitor	0.8038
P-glycoprotein inhibitor II	Non-inhibitor	0.8628
Renal organic cation transporter	Non-inhibitor	0.9562
CYP450 2C9 substrate	Non-substrate	0.8008
CYP450 2D6 substrate	Non-substrate	0.9116
CYP450 3A4 substrate	Substrate	0.6551
CYP450 1A2 substrate	Non-inhibitor	0.9045
CYP450 2C9 inhibitor	Non-inhibitor	0.9144
CYP450 2D6 inhibitor	Non-inhibitor	0.9293
CYP450 2C19 inhibitor	Non-inhibitor	0.9099
CYP450 3A4 inhibitor	Non-inhibitor	0.8567
CYP450 inhibitory promiscuity	Low CYP Inhibitory Promiscuity	0.8086
Ames test	Non AMES toxic	0.9132
Carcinogenicity	Non-carcinogens	0.8632
Biodegradation	Not ready biodegradable	0.9941
Rat acute toxicity	2.3159 LD50, mol/kg	Not applicable
hERG inhibition (predictor I)	Weak inhibitor	0.9946
hERG inhibition (predictor II)	Non-inhibitor	0.7466

ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)

Not Available

Spectra

Spectrum	Spectrum Type	Splash Key
Predicted GC-MS Spectrum - GC-MS	Predicted GC-MS	splash10-0zfr-5392300000-04bc3e193569d5361cd9
Predicted MS/MS Spectrum - 10V, Positive (Annotated)	Predicted LC-MS/MS	splash10-004j-0000900000-935048b8d3cfe4303be1
Predicted MS/MS Spectrum - 10V, Negative (Annotated)	Predicted LC-MS/MS	splash10-004l-0001900000-6ec51b6c9a3b8ec21d1e
Predicted MS/MS Spectrum - 20V, Positive (Annotated)	Predicted LC-MS/MS	splash10-004i-0000900000-0b59d411d391a9e10b5b
Predicted MS/MS Spectrum - 20V, Negative (Annotated)	Predicted LC-MS/MS	splash10-004l-0044900000-b17186c06c8d328522e0
Predicted MS/MS Spectrum - 40V, Positive (Annotated)	Predicted LC-MS/MS	splash10-0f6x-5796200000-66f53c607488d1a33712
Predicted MS/MS Spectrum - 40V, Negative (Annotated)	Predicted LC-MS/MS	splash10-0g59-1292200000-ddc4c8c94295c8f4b0cc
Predicted 1H NMR Spectrum	1D NMR	Not Applicable
Predicted 13C NMR Spectrum	1D NMR	Not Applicable

Chromatographic Properties

Collision Cross Sections (CCS)

Adduct	CCS Value (Å²)	Source type	Source
[M-H]-	209.2471399	predicted	DarkChem Lite v0.1.0
[M-H]-	209.6925399	predicted	DarkChem Lite v0.1.0
[M-H]-	197.94159	predicted	DeepCCS 1.0 (2019)
[M+H]+	212.1786399	predicted	DarkChem Lite v0.1.0
[M+H]+	212.9159399	predicted	DarkChem Lite v0.1.0
[M+H]+	200.33716	predicted	DeepCCS 1.0 (2019)
[M+Na]+	212.2655399	predicted	DarkChem Lite v0.1.0
[M+Na]+	212.5330399	predicted	DarkChem Lite v0.1.0
[M+Na]+	206.24968	predicted	DeepCCS 1.0 (2019)

Targets

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1. 30S ribosomal protein

Kind

Group

Organism

Not Available

Pharmacological action

Yes

Actions

Inhibitor

Group which encompasses the subunits of the 30S ribosomal protein not specific to any organism.

References

Patel RS, Parmar M: Doxycycline Hyclate . [Article]
FDA Approved Drug Products: DORYX (doxycycline hyclate) delayed-release tablets, for oral use [Link]

Enzymes

Details1. Cytochrome P450 3A4

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Inhibitor
Curator comments: CYP3A4 inhibition was demonstrated in a single in vitro study, where doxycycline inhibited CYP3A4-mediated metabolism of quinine to 3-hydroxyquinine.

General Function: Vitamin d3 25-hydroxylase activity
Specific Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name: CYP3A4
Uniprot ID: P08684
Uniprot Name: Cytochrome P450 3A4
Molecular Weight: 57342.67 Da

References

Zhao XJ, Ishizaki T: A further interaction study of quinine with clinically important drugs by human liver microsomes: determinations of inhibition constant (Ki) and type of inhibition. Eur J Drug Metab Pharmacokinet. 1999 Jul-Sep;24(3):272-8. [Article]
Zhao XJ, Ishizaki T: The In vitro hepatic metabolism of quinine in mice, rats and dogs: comparison with human liver microsomes. J Pharmacol Exp Ther. 1997 Dec;283(3):1168-76. [Article]
Tan KR, Magill AJ, Parise ME, Arguin PM: Doxycycline for malaria chemoprophylaxis and treatment: report from the CDC expert meeting on malaria chemoprophylaxis. Am J Trop Med Hyg. 2011 Apr;84(4):517-31. doi: 10.4269/ajtmh.2011.10-0285. [Article]
CYP3A4 document, CTEP [File]
MEDICATIONS METABOLIZED BY CYTOCHROME P450 3A4 [File]

Carriers

Details1. Serum albumin

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Substrate
Binder

General Function: Toxic substance binding
Specific Function: Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloid...
Gene Name: ALB
Uniprot ID: P02768
Uniprot Name: Serum albumin
Molecular Weight: 69365.94 Da

References

Aver'eva EV, Kivman GIa, Markovich MN, Shraiber NF, Pognoevskii OT: [Competition of antibacterial drugs for binding sites of human serum albumin]. Antibiot Khimioter. 1988 Jun;33(6):444-8. [Article]

Transporters

Details1. Solute carrier family 22 member 6

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Inhibitor

General Function: Sodium-independent organic anion transmembrane transporter activity
Specific Function: Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one ...
Gene Name: SLC22A6
Uniprot ID: Q4U2R8
Uniprot Name: Solute carrier family 22 member 6
Molecular Weight: 61815.78 Da

References

Babu E, Takeda M, Narikawa S, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Sakthisekaran D, Endou H: Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76. [Article]
In Vitro and In Vivo Evidence of the Importance of Organic Anion Transporters (OATs) in Drug Therapy [File]

Details2. ATP-binding cassette sub-family B member 5

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Inducer

General Function: Efflux transmembrane transporter activity
Specific Function: Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug do...
Gene Name: ABCB5
Uniprot ID: Q2M3G0
Uniprot Name: ATP-binding cassette sub-family B member 5
Molecular Weight: 138639.48 Da

References

Mealey KL, Barhoumi R, Burghardt RC, Safe S, Kochevar DT: Doxycycline induces expression of P glycoprotein in MCF-7 breast carcinoma cells. Antimicrob Agents Chemother. 2002 Mar;46(3):755-61. [Article]
A ROLE OF P-GLYCOPROTEIN IN MODULATION OF ANTIBIOTIC PHARMACOKINETICS [File]

Drug created at June 13, 2005 13:24 / Updated at May 30, 2024 20:36

Doxycycline

Identification

Structure for Doxycycline (DB00254)

Pharmacology

Interactions

Products

Categories

Chemical Identifiers

References

Clinical Trials

Pharmacoeconomics

Properties

Spectra

Collision Cross Sections (CCS)

Targets

References

Enzymes

References

Carriers

References

Transporters

References

References