In the late 1940s, Hartford was a model for Vogue.
Her screen debut was in A Girl in Every Port (1952), directed by Chester Erskine. In 1964-65, she made three guest appearances on Perry Mason; as Leslie Ross in "The Case of the Accosted Accountant," as Lois Gray in "The Case of the Missing Button", and she played Rhonda Coleridge in "The Case of the Baffling Bug". In 1964, she also appeared in "The Bewitchin' Pool", (the last original episode of The Twilight Zone to be broadcast, but not the last one to be filmed).
Hartford also guest starred in Gunsmoke, Burke's Law, The Outer Limits, The Alfred Hitchcock Hour, The Cara Williams Show, Batman (two episodes), Time Tunnel, Land of the Giants, and Lost in Space (three episodes). She appeared as the android Verda in the 1966 Lost in Space episode "The Android Machine" and in a sequel, "Revolt of the Androids". She also appeared in a third episode of Lost in Space as Nancy Pi Squared in the “Space Beauty” episode about an intergalactic beauty pageant.
