- Mark Wahlberg
- John Bennett
- Mila Kunis
- Lori
- Seth MacFarlane
- Ted, Director, Producer, Screenwriter
- Joel McHale
- Rex
- Giovanni Ribisi
- Donny
- Patrick Warburton
- Guy
- Matt Walsh
- Thomas
- Jessica Barth
- Tami-Lynn
- Aedin Mincks
- Robert
- Bill Smitrovich
- Frank
- Patrick Stewart
- Norah Jones
- Sam Jones
- Tom Skerritt
- Brett Manley
- Young John
- Ralph Garman
- John's Dad
- Alex Borstein
- John's Mom
- John Viener
- Alix
- Laura Vandervoort
- Tanya
- Seth MacFarlane
- Ted, Director, Producer, Screenwriter
- Alec Sulkin
- Screenwriter
- Wellesley Wild
- Screenwriter
- Scott Stuber
- Producer
- John Jacobs
- Producer
- Jason Clark
- Producer
- Jon Mone
- Executive Producer
- Michael Barrett
- Cinematographer
- Stephen J. Lineweaver
- Production Design
- Jeff Freeman
- Film Editing
- Debra McGuire
- Costume Design
- Walter Murphy
- Original Music
- Sheila Jaffe
- Casting
- E. David Cosier
- Art Director
- Kyra Friedman Curcio
- Set Decoration
