- Robert De Niro
- Jack Byrnes, Producer
- Ben Stiller
- Greg Focker
- Dustin Hoffman
- Mr. Focker
- Barbra Streisand
- Mrs. Focker
- Blythe Danner
- Dina Byrnes
- Teri Polo
- Pam Byrnes
- Tim Blake Nelson
- Officer LeFlore
- Alanna Ubach
- Isabel Villalobos
- Ray Santiago
- Jorge Villalobos
- Kali Rocha
- Flight Attendant
- Shelley Berman
- Judge Ira
- Owen Wilson
- Kevin Rawley
- Spencer Pickren
- Little Jack 'L.J.' Byrnes
- Bradley Pickren
- Little Jack 'L.J.' Byrnes
- Jay Roach
- Director
- John Hamburg
- Writer
- Jim Herzfeld
- Writer
- Marc Hyman
- Writer
- Amy Sayres
- Executive Producer
- Nancy Tenenbaum
- Executive Producer
- Robert De Niro
- Jack Byrnes, Producer
- Jane Rosenthal
- Producer
- Jon Poll
- Film Editing, Producer
- Randy Newman
- Original Music
- John Schwartzman
- Cinematographer
- Francine Maisler
- Casting
- Rusty Smith
- Production Design
- Andrew Neskoromny
- Art Director
- Sara Andrews
- Set Decoration
- Carol Ramsey
- Costume Design