- William Shatner
- Admiral James T. Kirk
- Leonard Nimoy
- Captain Spock
- Ricardo Montalban
- Khan Noonien Singh
- DeForest Kelley
- Commander Leonard H. McCoy, M.D.
- James Doohan
- Commander Montgomery Scott
- Walter Koenig
- Commander Pavel Andreievich Chekov
- George Takei
- Commander Hikaru Sulu
- Nichelle Nichols
- Commander Nyota Uhura
- Kirstie Alley
- Lieutenant Saavik
- Bibi Besch
- Dr. Carol Marcus
- Merritt Butrick
- Dr. David Marcus
- Paul Winfield
- Captain Clark Terrell
- Nicholas Meyer
- Director
- Harve Bennett
- Executive Producer, Writer
- Jack Sowards
- Writer
- Robert Sallin
- Producer
- William F. Phillips
- Associate Producer
- Gayne Rescher
- Cinematographer
- William Paul Dornisch
- Film Editing
- James Horner
- Original Music
- Joseph R. Jennings
- Production Design
- Michael Minor
- Art Director
- Charles Graffeo
- Set Decoration
- Robert Fletcher
- Costume Design
- Mary V. Buck
- Casting
- Werner Keppler
- Makeup Artist
- James Lee McCoy
- Makeup Artist
- Dione Taylor
- Hair Stylist
- Austen Jewell
- Unit Production Manager
- Douglas E. Wise
- First Assistant Director
