Sophia was born on May 1, 1585. Her mother died the same year, and her father Prince Yury Semenovich died on May 6, 1586. Because of debts the Chodkiewiczes owed to the Radziwill family, it became expedient to make a match between Sophia and Janusz Radziwill, Prince of Nesvizh and a son of the governor of Vilnius, Prince Krzysztof Radziwill.
She was canonized by the Orthodox Church in 1983. The church of Saint Sophia of Slutsk in Minsk is named after her. Sophia was raised by distant relatives, first by the governor of Samogitia province Yury Chodkiewicz (of the Chodkiewicz family) who took her to Vilnius, and then by the governor of Brest province, Hieronymus Chodkiewicz.
At this time Sophia was eleven years old.
The wedding between Sophia and Janusz was scheduled for February 6, 1600 in Vilnius. Before this happened there was a falling out between the Chodkiewiczes and the Radziwills, almost certainly over the financial arrangements that the wedding was contingent upon.
The matter proceeded to a court but the decision was in favor of the Radziwills, possibly because the judge rendering the verdict was Jerzy Radziwill. Rather than accept the verdict the Chodkiewiczes retreated with Sophia to their castle in Vilnius.
Janusz Radziwill’s father Krzysztof collected 6,000 troops in Vilnius and prepared for battle against the Chodkiewiczes with their 2,500 troops.
The tense situation was only calmed when four senators sent by the Polish King Sigismund III Vasa arrived and began to resolve the conflict through negotiations. A compromise was hammered out whereby the property claims of the Radziwills against the Chodkiewiczes were nullified and the latter were indemnified for their handling of the assets of Princess Sophia. Janusz Radziwill petitioned Pope Clement VIII for permission to marry Sophia on July 20, 1600.
Because Sophia was adamant in her decision to remain Orthodox and raise any children in the this led to a written discussion on the subject of interdenominational marriage between the Pope and the Patriarch of Constantinople.
The marriage between Sophia and Janusz took place in one of the cathedrals of Brest-Litovsk (now Brest) in accordance with the Orthodox rites on October 1, 1600. Other measures were enacted forbidding Uniate (Catholic) priests from replacing Orthodox priests when the latter died.
Sophia was generous in her donations to churches, monasteries, and the clergy. Sophia died in childbirth at Myleniec (Omelevo), near the town of Chervyen on March 19, 1612 at the age of 26.
Originally buried in the castle church of the Holy Trinity in Slutsk, her relics are currently in the Holy Spirit Cathedral in Minsk.
