- James Stewart
- George Bailey
- Donna Reed
- Mary Hatch Bailey
- Lionel Barrymore
- Mr. Henry F. Potter
- Thomas Mitchell
- William Bailey
- Henry Travers
- Clarence Oddbody
- Beulah Bondi
- Mrs. Bailey
- Frank Faylen
- Ernie Bishop
- Ward Bond
- Bert
- Gloria Grahame
- Violet Bick
- H.B. Warner
- Mr. Gower
- Frank Albertson
- Sam Wainwright
- Todd Karns
- Harry Bailey
- Samuel S. Hinds
- Peter Bailey
- Sheldon Leonard
- Nick
- Ellen Corby
- Miss Davis
- Virginia Patton
- Ruth Dakin Bailey
- Mary Treen
- Tilly
- Charles Williams
- Eustace
- Sarah Edwards
- Mrs. J.W. Hatch
- William Edmunds
- Giuseppe Martini
- Argentina Brunetti
- Mrs. Martini
- Lillian Randolph
- Annie
- Robert J. Anderson
- Little George
- Ronnie Ralph
- Little Sam
- Jean Gale
- Young Mary
- Jeanine Ann Roose
- Little Violet
- Frank Hagney
- Potter's bodyguard
- Carol Coombs
- Janie Bailey
- Karolyn Grimes
- Zuzu Bailey
- Larry Simms
- Peter Bailey
- Frank Capra
- Director, Producer, Writer
- Frances Goodrich
- Writer
- Albert Hackett
- Writer
- Philip Van Doren Stern
- Writer
- Jo Swerling
- Writer
- Dimitri Tiomkin
- Original Music
- Joseph F. Biroc
- Cinematographer
- Joseph Walker
- Cinematographer
- William Hornbeck
- Film Editing
- Jack Okey
- Art Director
- Emile Kuri
- Set Decoration
- Edward Stevenson
- Costume Design
- Gordon Bau
- Makeup Supervisor
- Arthur S. Black Jr.
- Assistant Director
- Clem Portman
- Sound
- Richard Van Hessen
- Sound
