Samuel Chukwueze gets a rare start with Rafael Leao and Olivier Giroud, as Milan try to lock down second place against a Genoa side missing Albert Gudmundsson.
It kicks off at San Siro at 17.00 UK time (16.00 GMT).
The Rossoneri have already qualified for the Champions League, but still want to guarantee second place, even if coach Stefano Pioli knows his time is up.
Theo Hernandez and Fikayo Tomori return from bans after the chaotic Derby della Madonnina, but Yunus Musah and Davide Calabria are suspended.
Ruben Loftus-Cheek, Mike Maignan, Luka Jovic and Simon Kjaer are out injured, so Chukwueze gets a rare start on the right wing, moving Christian Pulisic to a more central role behind Giroud.
Genoa secured Serie A safety last week and have agreed a contract extension with coach Alberto Gilardino, so the mood is confident.
However, top scorer Gudmundsson misses out with flu symptoms, while Ruslan Malinovskyi, Mattia Bani, Alan Matturro and former Milan man Junior Messias are all injured.
Milan vs. Genoa line-ups
Milan: Sportiello; Florenzi, Gabbia, Tomori, Theo Hernandez; Reijnders, Bennacer; Chukwueze, Pulisic, Leao; Giroud
Genoa: Martinez; Vogliacco, De Winter, Vasquez; Spence, Frendrup, Badelj, Thorsby, Martin; Ekuban, Retegui
Player statistic
| 5' |  |
Mateo Retegui | ||
| Tijjani Reijnders |  |
43' | ||
| Alessandro Florenzi (Assist: Samuel Chukwueze) |
 |
45' |
| 48' | |
Caleb Ekuban (Assist: Alessandro Vogliacco) | ||
| Matteo Gabbia (Assist: Alessandro Florenzi) |
|
72' | ||
| Olivier Giroud (Assist: Christian Pulisic) |
|
75' |
