The Killam Seminar Series
Schedule
Tue May 21 2024 at 04:00 pm to 05:00 pm
UTC-04:00Location
De Grandpre Communications Centre | Montréal, QC
About this Event
Supported by the generosity of the Killam Trusts, the MNI's Killam Seminar Series invites outstanding guest speakers whose research is of interest to the scientific community at the MNI and McGill University.
Talk Title: Schwann Cell Plasticity in Normal and Pathologic Human Peripheral Nerve
Alan Pestronk
Professor, Neurology and Pathology & Immunology, Washington University School of Medicine, Saint Louis, Missouri, USA
Abstract: Peripheral nerve Schwann cells and myelin have varied molecular phenotypes, related to age, axon size and nerve pathology. In normal adult peripheral nerve, myelin has two different patterns of molecular composition. Myelin basic protein is mostly absent from myelin around a population of intermediate-sized axons, whereas P0 protein is present in myelin around all axons. Denervated Schwann cells have a molecular signature that differs from normal SC types. With acute axon loss, myelinating Schwann cells upregulate NCAM. Chronically denervated Schwann cells express both NCAM and P0. Studies of myelin and related cell composition in peripheral and central nervous system should provide insights into the pathogenesis and anatomical localization of nervous disease processes.
Speaker Bio: Alan Pestronk is the Director of the Neuromuscular Division and the Neuromuscular Clinical Laboratory at Washington University School of Medicine. His research interests are broad and include clinical neurology, immune myopathies, neuromuscular disease, neuroimmunology, and the effects of aging on the nervous system. His research reflects this breadth of interest and his lab researches a wide variety of autoimmune and genetic diseases of nerves and muscles.
Where is it happening?
De Grandpre Communications Centre, 3801 Rue University, Montréal, CanadaEvent Location & Nearby Stays:
CAD 0.00