The Discovery of Exarafenib (KIN-2787): Overcoming the Challenges of Pan-RAF Kinase Inhibition求助PDF文件 - Book学术

文献互助智能选刊最新文献

高级搜索发布求助登录注册

首页 > 文献互助> 求助详情

The Discovery of Exarafenib (KIN-2787): Overcoming the Challenges of Pan-RAF Kinase Inhibition

待确认 10 由立秋发布于 2024/5/11 17:37:26

DOI:10.1021/acs.jmedchem.3c01830
作者：Young K. Chen*, Toufike Kanouni, Lee D. Arnold, Jason M. Cox, Elisabeth Gardiner, Kathryn Grandinetti, Ping Jiang, Stephen W. Kaldor, Catherine Lee, Chun Li, Eric S. Martin, Nichol Miller, Eric A. Murphy, Noel Timple, John S. Tyhonas, Angie Vassar, Tim S. Wang, Richard Williams, Ding Yuan and Robert S. Kania*,
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：RAF, a core signaling component of the MAPK kinase cascade, is often mutated in various cancers, including melanoma, lung, and colorectal cancers. The approved inhibitors were focused on tar

应助信息

等待求助人确认

求助人未确认前，本求助不能再次应助。48小时后系统将自动确认应助成功。本求助将自动关闭。

4小时前

heqiang

14f3b1dd0f7a11ef9d0434735aa3bc31.pdf

4小时前

Book学术机器人

2024/5/11 17:37:26 未找到该文献，机器人已退出，请等待人工下载

2024/5/11 17:37:26 Book学术AI机器人收到请求，开始寻找文献

2024/5/11 17:37:26 已向机器人发送请求

4小时前

立秋发布求助

上一个求助:其它数据库Naturally Fractured Carbonate Reservoir Characterization: A Case Study of a Mature High-Pour Point Oil Field in Hungary 下一个求助:WileyK2S2O8-Mediated Efficient Oxidative Deoximation of Flavonoid Oximes under Mild Reaction Conditions