Munster have made five personnel changes and two positional switches to the side that beat Connacht for their BKT URC trip to Edinburgh tomorrow (7.35pm).
Mike Haley and Antoine Frisch come into the backline in place of Simon Zebo and Sean O'Brien.
Oli Jager, Fineen Wycherley and Gavin Coombes start in the pack, replacing Stephen Archer, RG Snyman and Peter O'Mahony, respectively.
Alex Nankivell moves to inside centre and Jack O’Donoghue shifts from number 8 to blindside flanker.
O’Donoghue will make his 200th appearance for Munster, third in the table, becoming the 14th player to achieve the feat.
Having turned 30 in February, the Waterford man becomes the youngest-ever player to reach the landmark.
Haley starts at full-back with in-form wingers Calvin Nash and Shane Daly keeping their places in Graham Rowntree's side against seventh-place Edinburgh, whose only home defeat this season came against Benetton in round six.
The half-back partnership of Craig Casey and Jack Crowley is unchanged as Nankivell (above), man of the match against Connacht, and Frisch renew their centre partnership.
Jeremy Loughman, Niall Scannell and Jager pack down in the front row as Jager makes his first start since February after recently recovering from a knee injury.
Fineen Wycherley and captain Tadhg Beirne start together in the engine room with O’Donoghue, Alex Kendellen and Coombes completing the starting XV.
Kendellen, Coombes and replacement Tom Ahern have featured in all 21 fixtures so far this season in the URC and Champions Cup.
Eoghan Clarke, academy loosehead Mark Donnelly and John Ryan provide the front row back-up.
Snyman, Ahern and academy back-row Brian Gleeson complete the forward cover.
Gleeson is in line for his 10th appearance of the campaign which will be his first since January’s Champions Cup clash against Northampton Saints in Thomond Park.
Conor Murray and Rory Scannell are the backline replacements, while Joey Carbery and O'Mahony were unavailable for selection due to knocks.
Meanwhile, former Munster out-half Ben Healy will start for the hosts. The Tipperary man has been an ever-present for the Scottish outfit this season.
Munster: Mike Haley; Calvin Nash, Antoine Frisch, Alex Nankivell, Shane Daly; Jack Crowley, Craig Casey; Jeremy Loughman, Niall Scannell, Oli Jager; Fineen Wycherley, Tadhg Beirne (capt); Jack O'Donoghue, Alex Kendellen, Gavin Coombes.
Replacements: Eoghan Clarke, Mark Donnelly, John Ryan, RG Snyman, Tom Ahern, Conor Murray, Rory Scannell, Brian Gleeson.
Edinburgh: Wes Goosen; Matt Currie, Mark Bennett, James Lang, Duhan van der Merwe; Ben Healy, Ben Vellacott (co-capt); Pierre Schoeman, Ewan Ashman, WP Nel;, Sam Skinner, Grant Gilchrist (co-capt); Jamie Ritchie, Hamish Watson, Viliame Mata.
Replacements: Dave Cherry, Boan Venter, Javan Sebastian, Marshall Sykes, Luke Crosbie, Ali Price, Cammy Scott, Chris Dean.
Listen to the RTÉ Rugby podcast on Apple Podcasts, Spotify or wherever you get your podcasts.
Watch Connacht v Stormers in the URC on Saturday from 4.30pm on RTÉ2 and RTÉ Player, follow live score updates on rte.ie/sport and the RTÉ News app and listen to updates on Saturday Sport on RTÉ Radio 1
Listen to live commentary of Ulster v Leinster on RTÉ Radio 1
