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The gut microbe pair of Oribacterium sp. GMB0313 and Ruminococcus sp. GMB0270 confers complete protection against SARS-CoV-2 infection by activating CD8+ T cell-mediated immunity | Gut Microbes
In this study, we identified a pair of gut microbes, Oribacterium sp. GMB0313 and Ruminococcus sp. GMB0270, which plays a protective role against SARS-CoV-2 infection. Using SH101 Roborovski hamsters, a lethal animal model of COVID-19, we conducted fecal microbiota transplantation from an individual with no history of COVID-19 infection or immunization.
This induced diverse phenotypic changes in COVID-19 sensitivities, including complete protection against COVID-19. Through comparative metagenome analysis of these animal groups, we identified the two novel gut microbes that confer protection against SARS-CoV-2 infection.
Colonizing this microbial pair in the hamsters resulted in complete protection against SARS-CoV-2 infection by activating the CD8+ T cell population.
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