Why Muscle Spasms Hurt and How to Stop Them

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If you've ever felt a sudden, intense tightening in your muscles, you've experienced a muscle spasm, also referred to as a charley horse. These spasms, often felt in areas like the neck, legs, or back, can cause significant discomfort. While they may seem similar to cramps, muscle spasms are distinct in their abrupt onset and intensity.

This article explores what muscle spasms are and their link to pain and provide insights into the best medications and exercises to alleviate this discomfort when they strike.

Woman with sore leg

Vadym Petrochenko / Getty Images

How Muscle Spasms Feel

A muscle spasm feels incredibly tight, often likened to a knot in the affected muscle. The pain associated with a spasm can be severe, causing discomfort and restricting movement. During a spasm, the muscle contracts involuntarily and remains in a state of tension without relaxing. Symptoms include the following:

  • Muscle feels feels very tight, like a knot in the muscle.
  • Pain can be severe and intense.
  • It commonly occurs in the legs but can happen in any muscle.
  • Muscle contracts without control.
  • Muscle does not relax, remaining tense and uncomfortable.

Muscle spasms can occur in any muscle in the body but are frequently experienced in the legs. These cramps can affect a specific part of a muscle, the entire muscle, or multiple muscles within a group. The muscle groups most frequently affected are:

  • Gastrocnemius (back of the lower leg/calf)
  • Hamstrings (back of the thigh)
  • Quadriceps (front of the thigh)

Causes and Triggers of Muscle Spasms

A muscle spasm can occur due to various factors that lead to a muscle's sudden, involuntary contraction. These spasms can be triggered by the following:

  • Dehydration
  • Electrolyte imbalances, especially low levels of potassium or calcium
  • Overexertion or fatigue during physical activity
  • Muscle fatigue and inadequate stretching
  • Exercising in intense heat
  • Prolonged sitting or standing in awkward positions, causing muscle fatigue and spasms
  • Nerve compression, such as a pinched nerve in the neck

These factors can individually or collectively contribute to the onset of muscle spasms, causing discomfort and temporary impairment of muscle function.

Risk factors for muscle spasms include:

  • Age, especially infants and people over 65
  • Being overweight
  • Illness
  • People with nerve disorders or thyroid disease
  • Pregnancy

Neurological Disorders That Cause Muscle Spasms

Several neuromuscular disorders can also significantly impact muscle function, leading to symptoms like muscle spasms and twitching. These conditions may include:

  • Multiple sclerosis (MS), which can cause muscle spasms due to damage to the nerves that control muscle movement
  • Amyotrophic lateral sclerosis (ALS), in which muscle spasticity and cramps are early common symptoms
  • Spinal cord injuries, which can lead to spasticity and involuntary muscle contractions

Medications That Cause Muscle Spasms 

Certain medications can potentially trigger muscle spasms as a side effect. These spasms can be caused by medications that affect nerve signals or disrupt electrolyte balance in the body. Medications known for causing muscle spasms as a side effect are:

  • Diuretics (remove excess fluid from the body): These medications, commonly used to treat high blood pressure and edema (swelling), can lead to electrolyte imbalances such as low potassium levels, which in turn may cause muscle spasms.
  • Stimulant medications: Drugs like amphetamines or those used for attention deficit hyperactivity disorder (ADHD) can increase muscle activity, potentially leading to muscle spasms and twitching.
  • Statins: While primarily used to lower cholesterol levels, statin medications can sometimes cause muscle-related side effects, including muscle spasms, weakness, or cramps.

Individuals taking these medications must be aware of potential side effects and consult their healthcare provider if they experience muscle spasms or related symptoms.

What to Do During a Muscle Spasm

During a muscle spasm, it's important to take certain steps to alleviate discomfort and promote relaxation of the affected muscle. Here's what you can do during a muscle spasm:

  • Stop activity: If a muscle spasm occurs during physical activity, stop the activity immediately to prevent further strain or injury to the muscle.
  • Stretch gently: Slowly and gently stretching the affected muscle can help relax the contraction. Avoid sudden or forceful movements that could exacerbate the spasm.
  • Apply heat or cold: Applying heat (such as a warm towel or heating pad) or cold (such as an ice pack) to the spasm area can help relieve pain and reduce muscle tension.
  • Massage: Lightly massaging the muscle in the direction of the muscle fibers can promote relaxation and improve blood flow to the area.
  • Hydrate and replenish electrolytes: Drinking water and consuming electrolyte-rich fluids or foods (like bananas for potassium) can help prevent further spasms, especially if dehydration or electrolyte imbalance is a contributing factor.

If muscle spasms occur frequently, are severe, or are associated with other concerning symptoms, it's essential to seek medical evaluation to identify underlying causes and receive appropriate treatment.

Medical Interventions for Muscle Spasms

In some cases your healthcare provider may prescribe a medication to help manage muscle spasms. These may include:

Muscle Relaxants

Muscle relaxants such as baclofen or dantrolene, work by reducing muscle spasms and promoting muscle relaxation. They are often prescribed for short-term use to manage acute muscle spasms.

Benzodiazepine

Benzodiazepines are primarily used as a sedative, anxiety-reducing (anxiolytic), and anticonvulsant medication, they can also be used as a muscle relaxant to help alleviate muscle spasms.

Examples include:

  • Valium (diazepam)
  • Ativan (lorazepam)
  • Klonopin (clonazepam)

It is important to note that diazepam should be used cautiously and under the guidance of a healthcare provider. This medication can have sedative effects (inducing sleep) and may cause dependence or withdrawal symptoms if used long-term or in high doses.

Anticonvulsants

Some anticonvulsant medications, such as gabapentin or pregabalin, may also be used to help control muscle spasms, especially in conditions like multiple sclerosis or neuropathic pain where spasms are common.

Botulinum Toxin Injections

In cases of severe or chronic muscle spasms, injections of Botox (onabotulinumtoxinA) into the affected muscles can help relax the muscles and reduce spasms by blocking nerve signals.

It's important to note that the choice of medication depends on the underlying cause and severity of the muscle spasms, and should be determined by a healthcare provider.

If the Cause of Muscle Spasms Is Unknown

While most muscle cramps are typically harmless, they can sometimes indicate underlying health concerns, such as:

  • Irritation or compression of spinal nerves (radiculopathy)
  • Thyroid disorders
  • Liver cirrhosis
  • Atherosclerosis (hardening of the arteries)
  • Spinal canal narrowing (spinal stenosis)
  • Chronic infections
  • Amyotrophic lateral sclerosis, although this is rare

It's important to consult your healthcare provider if you experience:

  • Severe cramps
  • Frequent cramps
  • Cramps that do not respond well to basic treatments
  • Cramps unrelated to obvious causes like intense exercise or dehydration

These symptoms may indicate a more serious health condition and require medical evaluation.

Summary

Understanding the causes, symptoms, and treatments for muscle spasms is essential for managing discomfort. Whether they are caused by dehydration, electrolyte imbalances, nerve compression, or medications, muscle spasms can significantly impact daily life.

By implementing strategies such as gentle stretching, applying heat or cold, staying hydrated, and seeking medical advice for severe or frequent spasms, individuals can find relief and improve their quality of life. If you or a loved one is experiencing muscle spasms, talk to your healthcare provider for guidance and a treatment plan that is right for you.

19 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
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By Sarah Jividen, RN
Jividen is a freelance healthcare journalist. She has over a decade of direct patient care experience working as a registered nurse specializing in neurotrauma, stroke, and the emergency room.